Comparison between Oral and Written Spelling in Alzheimer's Disease

Written and oral spelling were compared in 33 patients with Alzheimer's disease (AD) and 25 control subjects. AD patients had poorer spelling results which were influenced by orthographic difficulty and word frequency, but not by grammatical word class. Lexical spelling was also more deteriorated than phonological spelling. Moreover, oral spelling was more impaired than written spelling in AD patients, whereas no difference was present between oral and written spelling of controls. Analysis of spelling errors showed that, for controls, errors were predominantly phonologically accurate in both spelling tasks. Significantly, AD patients produced more phonologically accurate than inaccurate errors in written spelling, whereas these errors did not differ in oral spelling. In contrast to controls who produced more constant than variable responses in oral and written spelling, AD patients made more variable responses (words correctly spelled in one task but incorrectly in the other) and they showed many instances of variable errors (different misspellings from one spelling task to the other). Two stepwise regression procedures showed that written misspellings were specifically correlated with language impairment, whereas oral spelling errors were correlated with attentional and language disorders. These results suggest that AD increases the attentional demands of oral spelling process as compared to written spelling. This dissociation argues, either for a unique Graphemic Buffer in which oral spelling requires more attentional resources than written spelling or for the hypothesis of separate buffers for oral and written spelling.     

Requiem for “schizophrenia”

In this article a brief overview of the treatment of chronic psychosis for the last two centuries is covered, with particular emphasis on many scientifically demonstrated causes of chronic organic psychosis and their medically successful treatment, including recent neurotransmitter manipulations. With respect for the important contributions of Bleuler, the term “schizophrenic” is considered as an unscientific and unprovable nosological construct, which has hampered the successful resolution of chronic psychosis and has outlived its usefulness in the lexicon of modern psychiatry.     

Are attentional dwell times inconsistent with serial visual search?

Duncan, Ward, and Shapiro (1994) estimated that attention must remain focused on an object for several hundred milliseconds before being shifted to another object, and they referred to this period as theattentional dwell time. An important implication of these long estimates of the dwell time for models of visual search is that the search process must not involve an item-by-item serial scanning mechanism. If it did, then searching through an array of items would require enormous amounts of time, which—based on data from visual search experiments—it does not. The present report, however, provides evidence that the long estimates of attentional dwell time were caused, at least in part, by the use of masked targets. Implications of these variable estimates of the attentional dwell time for models of visual search are discussed.     

Role of optical flow field asymmetry in the perception of heading during linear motion

During linear translation through a stationary environment, the pattern of optical flow generated on each retina is symmetrical when the head is aligned with the heading, but during lateral gaze the optical flow is asymmetric. We assessed whether human subjects could use the magnitude of this asymmetry to determine the direction of heading during passive translation through a 3-D environment. When allowed to move their heads in order to look in the direction of self-motion, subjects indicated their heading precisely and accurately. When the head was locked in alignment with the misaligned body, and gaze adjustments were not allowed, responses were quite precise, but showed a large bias which increased with increasing heading angle.     

Active and passive avoidance following the administration of systemic DSP4, xylamine, or p-chloroamphetamine

Groups of rats were administered either DSP4 (50 mg/kg, ip), xylamine (50 mg/kg, ip), or p-chloroamphetamine (2 X 10 mg/kg, ip), either 2 weeks or 1 week before the testing of two-way active avoidance. DSP4 and xylamine, the selective noradrenaline (NA) neurotoxins, caused a two-way avoidance impairment but p-chloroamphetamine, the selective 5-hydroxytryptamine (5-HT) neurotoxin, did not do so. Pretreatment with desipramine (20 mg/kg, ip) blocked the avoidance impairment caused by DSP4 and xylamine treatment. Neither DSP4 nor xylamine caused any alteration of passive avoidance retention. The biochemical analyses indicated severe NA, but not 5-HT, depletions in the DSP4 and xylamine conditions and drastic 5-HT, but not NA, depletions in the p-chloroamphetamine conditions. These results confirm and extend earlier findings concerning the role of NA in avoidance behavior.     

On abstraction and the doctrine of terms in eighteenth-century philosophy of language

The aim of this paper is to understand why empiricist philosophers of language did not try to refute the Leibniz-Beauzée argument, which questioned the genetical priority of proper names. It is shown that, within the semantic theory which underlies the empiricist doctrine, one may assume that all general terms derive from particular names, while conceding that every proper name can be etymologically traced back to the ancestor of a common noun.     

A cognitive mediation theory of task goals and human performance

A theory is proposed to explain the linkages between individual task goals and performance. Two cognitive constructs are postulated to mediate between task goals and performance:performance expectancy and performance valence. It is asserted that an individual's task goal has a positive influence on performance expectancy and a negative influence on performance valence. Performance expectancy is proposed to have a positive influence on performance while performance valence is proposed to have a negative influence on performance. Task ability is hypothesized to influence performance both directly and indirectly through its influence on performance expectancy. A laboratory experiment was designed to test the causal model proposed by the theory. A path analysis on the data from this experiment provides strong support for the model, with performance expectancy, performance valence, and task ability predicting 63% of the variance in performance on the laboratory task.     

Philosophy of medicine and other humanities: Toward a wholistic view

A less analytic and more wholistic approach to philosophy, described as ‘best overall fit’ or ‘seeing how things all hang together,’ is defended in recent works by John Rawls and Richard Rorty and can usefully be applied to problems in philosophy of medicine. Looking at sickness and its impact upon the person as a central problem for philosophy of medicine, this approach discourages a search for necessary and sufficient conditions for being sick, and instead encourages a listing of “true and interesting observations” about sickness which reflect the convergence of a number of different viewpoints. Among the relevant viewpoints are other humanities disciplines besides philosophy and the social sciences. Literature, in particular, provides insights into the meaning and the uniqueness of episodes of sickness in a way that philosophers may otherwise fail to grasp.