The safety and efficacy of medications for preventive treatment of migraine is the subject of current concern and investigation in health care. Two single-center, double-blind, placebo-controlled studies were conducted to evaluate the efficacy and safety of topiramate for migraine prophylaxis. Seventy patients with a diagnosis of migraine were randomly assigned to topiramate-treated and placebo groups. The studies consisted of a 4-week baseline phase, a 6-8 week titration, and 8-12 weeks of maintenance. Topiramate was titrated from an initial dose of 25 mg/day to a target dose of 100 mg BID. The primary efficacy measure, the mean 28-day migraine frequency, was lower in topiramate-treated patients than in the placebo group (3.2 versus 3.8, P=.001). Similarly, topiramate treatment resulted in a significantly greater mean reduction in migraine frequency than did placebo (1.55 versus 0.47, P=.001) and a significantly higher responder rate (35.3% versus 8.3%, P=.008). Paresthesia was the most common side effect reported with topiramate treatment. Other topiramate-associated adverse events included altered taste, memory impairment, diarrhea, and appetite suppression/weight loss. The rates of discontinuation were similar for the topiramate group (n=10) and the placebo group (n=8). These results suggest that topiramate is effective and well tolerated in the preventive treatment of migraine headaches. 相似文献
Few studies have examined whether non-human tool-users understand the properties that are relevant for a tool's function.
We tested cotton-top tamarins (Saguinus oedipus) and rhesus macaques (Macaca mulatta) on an expectancy violation procedure designed to assess whether these species make distinctions between the functionally
relevant and irrelevant features of a tool. Subjects watched an experimenter use a tool to push a grape down a ramp, and then
were presented with different displays in which the features of the original tool (shape, color, orientation) were selectively
varied. Results indicated that both species looked longer when a newly shaped stick acted on the grape than when a newly colored
stick performed the same action, suggesting that both species perceive shape as a more salient transformation than color.
In contrast, tamarins, but not rhesus, attended to changes in the tool's orientation. We propose that some non-human primates
begin with a predisposition to attend to a tool's shape and, with sufficient experience, develop a more sophisticated understanding
of the features that are functionally relevant to tools. 相似文献
Pre-school children expect falling objects to travel in a straight line even when there are clear physical mechanisms that deviate the object's path (Hood, 1995). The current study set out to determine whether this expectancy is limited to humans. Cotton-top tamarins (Saguinus oedipus oedipus), a New World monkey species, were tested on Hood's (1995) experimental task where objects are dropped down a chimney connected by an opaque tube to one of three containers. Like human children, there was a significant tendency to search in the container underneath the chimney where the food was dropped on the first trial, even though aligned chimneys and containers were never connected. These search errors suggest that there may be a gravity bias that operates when both primate species fail to understand the constraints operating on object trajectories. Unlike human children however, tamarins were generally more likely to perseverate in making errors even though repeated testing and cost incentives were used. 相似文献
To investigate infants’ affective expressivity and maternal attuned responsiveness to infant expressivity in relation to early language achievement, 77 dyads were visited in their homes at 9 and 13 months, and mothers were interviewed about their children’s language between 9 and 21 months. Maternal responses that were attuned to infant affect, by selectively matching either the gradient features or the valence of infants’ affective expressions, were more predictive of children’s language achievement than maternal nonmatching responses; and maternal matching responses at 9 months were more predictive of children’s language achievements than maternal responses at 13 months. Moreover, maternal matching responses at 9 months predicted second-year language achievements over and above infant affect expressivity at 9 and 13 months, and over and above maternal matching responses at 13 months. Infants’ affective expressivity per se was not predictive. 相似文献
This article describes a single-session trauma-debriefing group conducted at a nursing home following the death of a resident on an outing. The group had as its core an existing weekly therapy group in the facility, with the addition of affected staff, family, and other residents who were on the outing. The treatment illustrates four principles relevant to counseling and psychotherapy in nursing homes: 1) recognition of death; 2) treatment in and of the milieu; 3) flexibility and structure; and 4) dealing with countertransference. Along the way, we see how the residents are capable of giving, and not merely receiving. 相似文献
This essay presents an ethnographic account of two divorced Catholic women's memories of praying to the Virgin Mary while seeking illegal abortions under the Romanian socialist regime. These women's stories focused on troubling memories of being in love, reflections that were retrospectively shaped by divorce. Drawing on Sigmund Freud's notion of the uncanny, I call these recollections uncanny memories of the self in love. Uncannily remembering one's self in love combines experiential self‐examination and ethical assessment of actions. The notion of the uncanny self in love thus helps bridge the divide between experience‐ and action‐oriented approaches to lived ethics. I argue that the ethical significance of the Virgin Mary's actions depended on my acquaintances’ approach to love. For one woman seeking to stay estranged from her ex‐husband, the Virgin Mary's actions accentuated his ethical immaturity. My other acquaintance harbored more ambivalent feelings toward her ex‐husband; for her, talking about the Virgin Mary helped her relativize feelings of ethical indignation. As a core implication of this argument, I urge greater awareness of the problematic tendency to include the need for greater awareness of tendencies in theories of lived ethics to reify socially situated perspectives on love. 相似文献
Objective: The feelings and emotions individuals associate with health-related behaviours influence engagement in those behaviours. However, the structure and the content of these affective associations have not been examined. The studies reported here examined competing hypotheses about the structure (unidimensional or bidimensional) and content (generalised affect or specific emotions) of affective associations with two health-related behaviours: physical activity and fruit/vegetable consumption.
Design: For each behaviour, participants (fruit and vegetable consumption n = 149; physical activity n = 199) completed an assessment of the association of 40 positive and 51 negative affect concepts with the behaviour.
Main outcome measures: Ratings of affective associations with each behaviour.
Results: Confirmatory factor analyses comparing unidimensional and bidimensional affect structure models showed that the structure of individuals’ affective associations was bidimensional for both behaviours – positive and negative affective associations were shown to be separate and distinct constructs. Exploratory factor analyses supported a model of affective associations as generalised affect for both behaviours.
Conclusion: Affective associations with both physical activity and with fruit/vegetable consumption consist of separate positive and negative dimensions of generalised affect. These findings lead to recommendations for research and intervention development based on the implications for how affective associations might operate to influence behavioural decision-making. 相似文献
This study examined links between two distinct facets of empathy-empathic accuracy and perceived empathic effort-and one's own and one's partner's relationship satisfaction. Using a video recall procedure, participants (n = 156 couples in committed relationships) reported on their own emotions and their perceptions of partners' emotions and partners' empathic intentions during moments of high affect in laboratory-based discussions of upsetting events. Partners' data were correlated as a measure of how accurately they were able to read what the other was feeling and to what degree they felt the other was trying to be empathic at those moments. The perception of empathic effort by one's partner was more strongly linked with both men's and women's relationship satisfaction than empathic accuracy. Men's relationship satisfaction was related to the ability to read their partners' positive emotions accurately, whereas women's relationship satisfaction was related to their partners' ability to read women's negative emotions accurately. Women's ability to read their husbands' negative emotions was positively linked to both men's and women's relationship satisfaction. Findings suggest that the perception of a partner's empathic effort-as distinct from empathic accuracy-is uniquely informative in understanding how partners may derive relationship satisfaction from empathic processes. When working with couples in treatment, heightening partners' perceptions of each other's empathic effort, and helping partners learn to demonstrate effort, may represent particularly powerful opportunities for improving satisfaction in relationships. 相似文献
The Youth Psychopathic Traits Inventory-Short Version (YPI-S; van Baardewijk et al., 2010) is a self-report measure to assess psychopathic-like traits in adolescents. The aim of the present study is to investigate the factor structure, the internal consistency, and the criterion validity of the YPI-S in 768 Belgian community adolescents (45.4?% males). In general, our study supported the YPI three factor structure while relevant indices showed that the instrument is internally consistent. In addition, relations between the YPI-S total score and dimension scores on the one hand and external criterion measures (e.g. conduct problems and self-reported offending) on the other hand were generally in line with predictions. The present study replicated and substantially extended previous findings of the YPI-S in a sample of community youth. Future studies are needed to test whether findings from community samples can be replicated in clinical-referred and justice-involved boys and adolescents. 相似文献