Relationships between early behavioural characteristics and temperament at 6 years

The aim of this study was to analyze the extent to which the relations and the stability of the neonatal behaviour and the infant behaviour at both 4 and 12 months could be used to predict the infant temperament at 6 years. Seventy-two full-term, normal-weight, healthy children were followed from 3 days postpartum to 6 years. Neonatal behaviour at 3 and 30 days was assessed using the Neonatal Behaviour Assessment Scale (NBAS), behaviour at 4 and 12 months was assessed using the Infant Behaviour Record (IBR) from the Bayley Scales for Infant Development (BSID) and temperament at 6 years was assessed using the Dimensions of Temperament Survey-Revised (DOTS-R). Negative and positive affectivity and attention were the factors extracted from the behaviours of the IBR. Our results showed a low/moderate correlation between neonatal behaviour on the one hand and behaviour at 4 and 12 months and temperament at 6 years on the other hand. The motor performance, orientation and ANS stability of the neonate at 3 and 30 days were predictors of positive and negative affectivity at 4 months. State regulation and ANS stability at 3 days were predictors of negative affectivity and attention respectively at 12 months. Negative affectivity at 12 months and endurance at 30 days were predictors of general activity and persistence/attention at 6 years. Also, an inverse relation was found between state regulation at 30 days and general activity at 6 years, and a positive relation was found between attention at 4 months and persistence/attention at 6 years. We conclude that neonatal behaviour and behaviour in the first year of life are good predictors of temperament at 6 years and that early negative affectivity has an important role on infant temperament development.     

Pre-training anandamide infusion within the basolateral amygdala impairs plus-maze discriminative avoidance task in rats

Endocannabinoids (eCBs) modulate a variety of brain functions via activation of the widely expressed CB1 receptor. One site of high density of this receptor is the basolateral amygdala (BLA), a structure involved in the formation of aversive memories. The activation and blockade of CB1 receptors by systemic or hippocampal drug administrations have been shown to modify memory processing. However, little is known about the role of the BLA endocannabinoid system in aversive memories. Additionally, BLA endocannabinoid transmission seems to be related to emotional states, but the relevance of these effects to memory formation is still unknown. In this study we investigated the effects of the eCB anandamide (AEA) and the CB1 antagonist/inverse agonist AM251 infused into the BLA on the acquisition of an aversive memory task, concomitantly evaluating basal anxiety levels in rats. Male rats received pre-training micro-injection of AEA, AM251 or vehicle bilaterally into the BLA, and were studied with the plus-maze discriminative avoidance task (a paradigm that allows concomitant and independent evaluation of anxiety-like behavior and the memory of an aversive task). Our results showed that AEA into the BLA before training prevented memory retrieval 24 h later, as evaluated by exploration of the aversive arm of the maze, while AM251 into the BLA did not interfere with animals' performance. In addition, AEA had no effect on anxiety-like behavior (as evaluated by open arm exploration and risk assessment), while AM251 induced an anxiogenic effect. Our data indicate an important role of BLA CB1 receptors in aversive memory formation, and suggest that this involvement is not necessarily related to a possible modulation of anxiety states.     

Task dependent modulation of exogenous attention: Effects of target duration and intervening events

Inhibition of return (IOR) consists of slower reaction times in response to stimuli appearing at previously attended or inspected locations. The exact mechanisms underlying the effect have not yet been determined. In the present work, we manipulated two variables, target duration and intervening event (fixation cue between cue and target), through which we modulated the IOR effect as a function of task. When the target was presented until response, the presence of an intervening event made the cueing effect more negative in all tasks, although facilitation in the absence of an intervening event was only observed in discrimination and go–no-go tasks. When the target duration was 50 ms, the effect of the intervening event on cueing was also only observed for the discrimination and go–no-go tasks. Target duration had no effect at all in the discrimination task. Possible mechanisms for these modulations (detection cost and spatial selection benefit, both of which are based on cue–target integration processes) are discussed.     

Facilitation and interference of behavioral responses by task-irrelevant affect-laden stimuli

Emotional interference on behavior is commonly observed when task-irrelevant negative stimuli appear before behavioral targets. One explanation postulates that affect-laden stimuli readily capture attention, interfering with the processing of the upcoming target. Emotional stimuli might also preactivate motor programs incompatible with the demanded response. Using a cued go/no-go procedure we showed that task-irrelevant unpleasant stimuli cause interference or facilitation depending on their onset asynchrony relative to the target. We observed interference with short (200 ms) stimulus-target asynchronies and facilitation for longer ones (600 ms), both for key press (Experiment 1) and key release (Experiment 2) responses. The interference effect is compatible with an attentional explanation, but the behavioral facilitation is hard to accommodate within either attentional or motor accounts. This interference-facilitation pattern can be explained assuming that once the attentional effect subsides, emotional processing may enhance the perceptual processing of the stimuli, or lower the decision threshold, thereby facilitating the response selection process.     

Reducing Ethical Hazards in Knowledge Production

This article discusses the ethics of knowledge production (KP) from a cultural point of view, in contrast with the more usual emphasis on the ethical issues facing individuals involved in KP. Here, the emphasis is on the cultural environment within which individuals, groups and institutions perform KP. A principal purpose is to suggest ways in which reliable scientific knowledge could be produced more efficiently. The distinction between ethical hazard and (un)ethical behaviour is noted. Ethical hazards cannot be eliminated but they can be reduced if the cultural ambience is suitable. The main suggestions for reducing ethical hazards in KP relate to the review process. It is argued that some defects of the current, largely anonymous, review process could be ameliorated by a process of comprehensive, open and ongoing review (COOR). This includes partial professionalisation of the work of reviewing. Review at several stages is a vital part of the long filtering that incorporates some claims into the canon of reliable knowledge. The review process would be an acknowledged and explicit part of KP—a respected, public and rewarded activity. COOR would be expensive but cost-effective. The costs should be built explicitly into research culture. Finally, the considerations about a more ‘KP friendly’ culture lead to advocacy of a ‘long-term, short-term’ synthesis; that is, of the synthesis of long-term vision, such as a more cooperative and less competitive culture, with incremental changes which may be implemented in the short term.     

The on-line resolution of the sentence complement/relative clause ambiguity: evidence from Spanish

Two self-paced reading experiments investigated syntactic ambiguity resolution in Spanish. The experiments examined the way in which Spanish subjects initially interpret sentences that are temporarily ambiguous between a sentence complement and a relative clause interpretation. Experiment 1 examined whether the sentence complement preference found in English is observed in Spanish speaking subjects. In Experiment 2, verbal mood was manipulated in order to study the influence of verb-specific information on sentence processing. Since subcategorization for a subjunctive complement clause is generally assumed to be a lexical property of some verbs, the manipulation of the mood of the embedded verb affords us an interesting and novel way to examine the influence of lexical information on syntactic ambiguity resolution. Experiment 1 showed that Spanish speakers initially interpret the ambiguous that-clause as a sentence complement. Experiment 2 showed that verb-specific information, in particular, the information that specificies that a verb subcategorizes for a subjunctive complement, is accessed and used rapidly and affects the ambiguity resolution process. The results are discussed in relation to current models of sentence processing.     

Can the eyes reveal a person’s emotions? Biasing role of the mouth expression

In this study we investigated how perception of the eye expression in a face is influenced by the mouth expression, even when only the eyes are directly looked at. The same eyes appeared in a face with either an incongruent smiling, angry, or sad mouth, a congruent mouth, or no mouth. Attention was directed to the eyes by means of cueing and there were no fixations on the mouth. Participants evaluated whether the eyes were happy (or angry, or sad) or not. Results indicated that the smile biased the evaluation of the eyes towards happiness to a greater extent than an angry or a sad mouth did towards anger or sadness. The smiling mouth was also more visually salient than the angry and the sad mouths. We conclude that the role of the eyes as a “window” to a person’s emotional and motivational state is constrained and distorted by the configural projection of an expressive mouth, and that this effect is enhanced by the high visual saliency of the smile.     

Coping with HIV Related Stigma and Well-Being

The goal of this study was to analyze the relationships to be found among stigma perception, active and avoidant coping strategies, and subjective and psychological well-being in a sample of 133 people with HIV. The results showed that stigma perception and avoidant coping strategies (venting, self-blame, denial, behavioural disengagement and substance use) were positively associated, whereas, both stigma perception and avoidant coping were negatively associated with different measures of well-being (affect balance, self-acceptance and environmental mastery). These negative relationships between stigma perception and the three well-being measures were mediated by the use of avoidant coping strategies. Results suggest that psychosocial intervention programs for people who report psychological distress arising from prejudice must be aimed at developing appropriate ways to deal with this prejudice. Intervention programs should also include strategies to directly increase well-being since from a positive psychology viewpoint certain interventions have been shown to do so, and HIV research has also shown that well-being is associated with lower mortality rates.     

Logically Incorrect Arguments

What do we learn when we find out that an argument is logically incorrect? If logically incorrect means the same as not logically correct, which in turn means not having a valid logical form, it seems that we do not learn anything too useful—an argument which is logically incorrect can still be conclusive. Thus, it seems that it makes sense to fix a stronger interpretation of the term under which a logically incorrect argument is guaranteed to be wrong (and is such for purely logical reasons). In this paper, we show that pinpointing this stronger sense is much trickier than one would expect; but eventually we reach an explication of the notion of (strong) logical incorrectness which we find non-trivial and viable.     

Spatial learning in rats is impaired by microinfusions of protein kinase C-gamma antisense oligodeoxynucleotide within the nucleus accumbens

The nucleus accumbens (NAcc) has been shown to play a role in motor and spatial learning. Protein kinase C (PKC) has been implicated in the mechanisms of initiation and maintenance of long-term potentiation that is thought to be involved in the storage of long-term memory. In the present study, the importance of de novo synthesis of PKC-gamma within the NAcc in the acquisition and retention of spatial discrimination learning was assessed using an antisense knockdown approach. Separate groups of Long-Evans rats were exposed to acute microinfusions (6microg/microl) of PKC-gamma antisense oligodeoxynucleotide (AS-ODN), control oligodeoxynucleotide (C-ODN) or vehicle into the NAcc at 24 and 3h before each training session. Behavioral findings showed that the blockade of NAcc-PKC-gamma translation caused impairments in the early phase of learning and retention of spatial information. Biochemical experiments showed that PKC-gamma expression was reduced and Ca(2+)/phospholipid-dependent protein kinase C (PKC) activity was blocked significantly in the AS-ODN-treated rats in comparison with control rats. The present findings suggest that NAcc-PKC-gamma plays a role during the early acquisition of spatial learning. Also, retention test results suggest that NAcc-PKC-gamma may be working as an intermediate factor involved in the onset of molecular mechanisms necessary for spatial memory consolidation within the NAcc.