The Perceived Advantages and Disadvantages of Presymptomatic Testing for Machado-Joseph Disease: Development of a New Self-Response Inventory

This study describes the construction of a self-response inventory to evaluate the perception of advantages and disadvantages of the Machado-Joseph disease presymptomatic testing, in 44 individuals at-risk for this disease. The results showed that the reliability of this inventory was satisfactory. Factor analysis revealed a bidimensional structure: perceived advantages (pros) and perceived disadvantages (cons) of presymptomatic testing. Social desirability was found unrelated to the total scores of our inventory. Additional correlation studies, with other scales, confirmed the convergent validity of the instrument. These results suggest adequate construct validity. This inventory thus seems to be a proper instrument to assess expectations involved in the decision-making process of Machado-Joseph disease presymptomatic testing.     

Auditory/visual duration bisection in patients with left or right medial-temporal lobe resection

Patients with unilateral (left or right) medial temporal lobe lesions and normal control (NC) volunteers participated in two experiments, both using a duration bisection procedure. Experiment 1 assessed discrimination of auditory and visual signal durations ranging from 2 to 8 s, in the same test session. Patients and NC participants judged auditory signals as longer than equivalent duration visual signals. The difference between auditory and visual time discrimination was equivalent for the three groups, suggesting that a unilateral temporal lobe resection does not modulate the modality effect. To document interval-timing abilities after temporal lobe resection for different duration ranges, Experiment 2 investigated the discrimination of brief, 50-200 ms, auditory durations in the same patients. Overall, patients with right temporal lobe resection were found to have more variable duration judgments across both signal modality and duration range. These findings suggest the involvement of the right temporal lobe at the level of the decision process in temporal discriminations.     

Preschool language and visuospatial skills respectively predict multiplication and addition/subtraction skills in middle school children

A converging body of evidence from neuroimaging, behavioral, and neuropsychology studies suggests that different arithmetic operations rely on distinct neuro-cognitive processes: while addition and subtraction may rely more on visuospatial reasoning, multiplication would depend more on verbal abilities. In this paper, we tested this hypothesis in a longitudinal study measuring language and visuospatial skills in 358 preschoolers, and testing their mental calculation skills at the beginning of middle school. Language skills at 5.5 years significantly predicted multiplication, but not addition nor subtraction scores at 11.5 years. Conversely, early visuospatial skills predicted addition and subtraction, but not multiplication scores. These results provide strong support for the existence of a double dissociation in mental arithmetic operations, and demonstrate the existence of long-lasting links between language/visuospatial skills and specific calculation abilities.     

For better or for worse: the congruence of personal and group outcomes on targets' responses to discrimination

This paper reports two studies examining how (in‐) congruence between personal and group outcomes affects emotional well‐being, outcome attributions and procedural justice perceptions of individuals who are exposed to subtle discrimination. In Study 1 (N = 82) participants are either accepted or rejected in a (bogus) job application procedure, and either do or do not receive additional information indicating group‐level disadvantage. In Study 2 (N = 79), participants were either accepted or rejected, and received information indicating either advantage or disadvantage for members of their group. Results of both studies reveal that not only emotional well‐being and outcome attributions, but also procedural justice perceptions are primarily guided by personal outcomes. That is, being informed of group‐level disadvantage does not intensify but can instead alleviate negative affect resulting from personal rejection. Furthermore, group disadvantage is only seen as an indicator of an unjust procedure by individual group members who have personally suffered rejection. Results are discussed in relation to current insights on discrimination, tokenism and social justice. Copyright © 2008 John Wiley & Sons, Ltd.     

Subitizing reflects visuo-spatial object individuation capacity

Subitizing is the immediate apprehension of the exact number of items in small sets. Despite more than a 100 years of research around this phenomenon, its nature and origin are still unknown. One view posits that it reflects a number estimation process common for small and large sets, which precision decreases as the number of items increases, according to Weber’s law. Another view proposes that it reflects a non-numerical mechanism of visual indexing of multiple objects in parallel that is limited in capacity. In a previous research we have gathered evidence against the Weberian estimation hypothesis. Here we provide first direct evidence for the alternative object indexing hypothesis, and show that subitizing reflects a domain general mechanism shared with other tasks that require multiple object individuation.     

The origins of word learning: Brain responses of 3‐month‐olds indicate their rapid association of objects and words

The present study explored the origins of word learning in early infancy. Using event‐related potentials (ERP) we monitored the brain activity of 3‐month‐old infants when they were repeatedly exposed to several initially novel words paired consistently with each the same initially novel objects or inconsistently with different objects. Our results provide strong evidence that these young infants extract statistic regularities in the distribution of the co‐occurrences of objects and words extremely quickly. The data suggest that this ability is based on the rapid formation of associations between the neural representations of objects and words, but that the new associations are not retained in long‐term memory until the next day. The type of brain response moreover indicates that, unlike in older infants, in 3‐month‐olds a semantic processing stage is not involved. Their ability to combine words with meaningful information is caused by a primary learning mechanism that enables the formation of proto‐words and acts as a precursor for the acquisition of genuine words.     

Psychometric evaluation and experimental validation of the statistics anxiety rating scale

The Statistics Anxiety Rating Scale (STARS) was adapted into German to examine its psychometric properties (n = 400). Two validation studies (n = 66, n = 96) were conducted to examine its criterion-related validity. The psychometric properties of the questionnaire were very similar to those previously reported for the original English version in various countries and other language versions. Confirmatory factor analysis indicated 2 second-order factors: One was more closely related to anxiety and the other was more closely related to negative attitudes toward statistics. Predictive validity of the STARS was shown both in an experimental exam-like situation in the laboratory and during a real examination situation. Taken together, the findings indicate that statistics anxiety as assessed by the STARS is a useful construct that is more than just an expression of a more general disposition to anxiety.     

GOOD or BAD responder? Behavioural and neuroanatomical markers of clinical response to donepezil in dementia

We explored the neuropsychological and neuromorphometrical differences between probable Alzheimer's disease patients showing a good or a bad response to nine months treatment with donepezil. Before treatment, the neuropsychological profile of the two patient groups was perfectly matched. By the ninth month after treatment, the BAD-responders showed a decline of the MMSE score together with a progressive impairment of executive functions. A voxel-based morphometry investigation (VBM), at the time of the second neuropsychological assessment, showed that the BAD-responders had larger grey and white matter atrophies involving the substantia innominata of Meynert bilaterally, the ventral part of caudate nuclei and the left uncinate fasciculus, brain areas belonging to the cholinergic pathways. A more widespread degeneration of the central cholinergic pathways may explain the lack of donepezil efficacy in those patients not responding to a treatment that operates on the grounds that some degree of endogeneous release of acetylcholine is still available.