Making the Decision to Participate in Predictive Genetic Testing for Arrhythmogenic Right Ventricular Cardiomyopathy

This paper describes the experience of predictive genetic testing for Arrhythmogenic Right Ventricular Cardiomyopathy in the context of novel gene discovery. Two approaches to making the decision to engage in genetic testing were apparent: the decision to be tested either (a) develops gradually over time or (b) happens so quickly that it is felt as a “fait accompli.” Six key factors that influenced the particular approach taken by the participants were identified: (1) scientific process—available and relevant predictive genetic test; (2) numerous losses or deaths within the family; (3) physical signs and symptoms of disease; (4) gender; (5) sense of relational responsibility or moral obligation to other family members; and (6) family support. This study found that at risk individuals juxtapose scientific knowledge against their experiential knowledge and the six identified factors in order to make the decision to participate in genetic testing. Recommendations include the creation of a relational space within which to provide psychological counselling and assessment for the six identified factors that shape the decision to engage in predictive genetic testing.     

Revisiting letter transpositions within and across morphemic boundaries

Early morphological decomposition of complex words has been supported by evidence showing that the magnitude of masked transposed-letter (TL) priming effects is greater for within-morpheme transpositions than for between-morpheme transpositions. However, these findings have lately been called into question, and a recent article by Sánchez-Gutiérrez and Rastle (Psychonomic Bulletin & Review, 20, 988–996, 2013) suggested that the above-mentioned interaction could have been the consequence of a false positive (i.e., a Type I error). Considering recent evidence showing that morpho-orthographic interactions are highly sensitive to individual differences in reading skills, we explored whether participants’ averaged reading speeds were responsible for modulating the size of within- versus between-morpheme TL priming effects. A large-scale lexical decision experiment with a set of 420 suffixed Spanish words (N = 80 participants) was run using the masked-priming technique. The results revealed that individual differences modulated the magnitude of the masked TL priming effect between morphemes: Faster readers (but not slower readers) yielded greater TL priming for within- than for between-morpheme transpositions. The present data help reconcile previous divergent data by showing that faster readers revealed a morpho-orthographic interaction, whereas slower readers may rely more on a morphological-processing strategy that is not sensitive to morpho-orthographic interactions.     

Facial expression recognition in peripheral versus central vision: role of the eyes and the mouth

This study investigated facial expression recognition in peripheral relative to central vision, and the factors accounting for the recognition advantage of some expressions in the visual periphery. Whole faces or only the eyes or the mouth regions were presented for 150 ms, either at fixation or extrafoveally (2.5° or 6°), followed by a backward mask and a probe word. Results indicated that (a) all the basic expressions were recognized above chance level, although performance in peripheral vision was less impaired for happy than for non-happy expressions, (b) the happy face advantage remained when only the mouth region was presented, and (c) the smiling mouth was the most visually salient and most distinctive facial feature of all expressions. This suggests that the saliency and the diagnostic value of the smile account for the advantage in happy face recognition in peripheral vision. Because of saliency, the smiling mouth accrues sensory gain and becomes resistant to visual degradation due to stimulus eccentricity, thus remaining accessible extrafoveally. Because of diagnostic value, the smile provides a distinctive single cue of facial happiness, thus bypassing integration of face parts and reducing susceptibility to breakdown of configural processing in peripheral vision.     

What do We Know about Family Interventions for Psychosis at the Process Level? A Systematic Review

The evidence regarding effectiveness of family interventions for psychosis (FIP) is strong and consistent. However, there is a gap in the research on the process of these interventions, and little is known about their active ingredients. This review aims to identify the active ingredients of FIP. We conducted a systematic literature review, focusing on qualitative research, and analyzed 22 papers in total. We found a single study comprehensively exploring the process of FIP. All other studies focused on particular aspects of process‐related variables. The key elements of FIP seem to be the so‐called “common therapeutic factors”, followed by education about the illness and coping skills training. This review supports the value of a stepped model of intervention according to the needs of the families. However, the evidence reviewed also reveals a gap in the research findings based on the limited research available. FIP are complex, psychosocial interventions with multiple components, and more intensive, qualitative research is needed to establish linkages between process and outcome.     

Paraconsistent and Paracomplete Logics Based on k-Cyclic Modal Pseudocomplemented De Morgan Algebras

Studia Logica - The study of the theory of operators over modal pseudocomplemented De Morgan algebras was begun in papers [20] and [21]. In this paper, we introduce and study the class of modal...     

The anaphase promoting complex is required for memory function in mice

Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis. On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and learning behavior. One of the key pathways mediating protein degradation is proteosomal protein destruction. The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that targets proteins for proteosomal degradation by the 26S proteasome. While the APC/C is essential for cell cycle progression it is also expressed in postmitotic neurons where it has been implicated with axonal outgrowth and neuronal survival. In this study we addressed the role of APC/C in learning and memory function by generating mice that lack the essential subunit APC2 from excitatory neurons of the adult forebrain. Those animals are viable but exhibit a severe impairment in the ability to extinct fear memories, a process critical for the treatment of anxiety diseases such as phobia or post-traumatic stress disorder. Since deregulated protein degradation and APC/C activity has been implicated with neurodegeneration we also analyzed the effect of Apc2 deletion in a mouse model for Alzheimer's disease. In our experimental setting loss of APC2 form principle forebrain neurons did not affect the course of pathology in an Alzheimer's disease mouse model. In conclusion, our data provides genetic evidence that APC/C activity in the adult forebrain is required for cognitive function.     

Reciprocal teaching and self-monitoring of strategy use: effects on reading comprehension

Reciprocal teaching (RT) is an instructional procedure to teach students cognitive strategies that might lead to improved reading comprehension. However, self-monitoring (SM) strategy use can optimize instruction of comprehension. Thus, the present study analyzed: (a) the efficacy of RT in regular classes and (b) the efficacy of RT + SM of strategy use. A sample of 59 students in the fourth year of primary education was selected: 19 children were selected as an RT condition, 18 as an RT + SM condition, while the remaining 22 made up the comparison group. Two types of comprehension measures were used: tasks of specific effects (getting the main idea, writing a summary, comprehension-monitoring test) and transfer effect measures (standardised tests, word meaning inference, and free recall). Thus, the results show that both the RT condition and the RT + SM condition benefited from the instruction, performing better than the comparison group in measures of specific effects and in some of the transfer effect measures. This result shows that SM is not a necessary component in the instruction of reading comprehension with RT.     

Alexithymia and experimentally induced emotion recognition in people with somatizations

This study is part of an investigation aimed at assessing the cognitive-emotional process of emotional recognition in somatizing patients. The specific objective was to verify whether there were differences in the self-assessment of emotional reaction among patients with somatization and non-clinical controls. To obtain the self-assessment of their emotional reaction in the affective dimensions of valence and activation in clinical and control participants, we resorted to a procedure that minimizes the use of verbal skills and comprehension. Participants were 119 people, 47 patients and 72 non-clinical participants. The prevalence of alexithymia in the clinical group was 42.55%, whereas in non-clinical controls, it was 30.55%. Results showed the existence of a deficit in the clinical group's self-assessment of activation in response to the corresponding images with high levels of the affective dimension of activation and high valence images, associated with the clinical condition but not with alexithymia. Alexithymia has a modulatory effect on the clinical participants' and controls' evaluation of the valence of the unpleasant images or of low valence pictures.