Chronically increased Gsalpha signaling disrupts associative and spatial learning

The cAMP/PKA pathway plays a critical role in learning and memory systems in animals ranging from mice to Drosophila to Aplysia. Studies of olfactory learning in Drosophila suggest that altered expression of either positive or negative regulators of the cAMP/PKA signaling pathway beyond a certain optimum range may be deleterious. Here we provide genetic evidence of the behavioral and physiological effects of increased signaling through the cAMP/PKA pathway in mice. We have generated transgenic mice in which the expression of a constitutively active form of Gsalpha (Gsalpha* Q227L), the G protein that stimulates adenylyl cyclase activity, is driven in neurons within the forebrain by the promoter from the CaMKIIalpha gene. Despite significantly increased adenylyl cyclase activity, Gsalpha* transgenic mice exhibit PKA-dependent decreases in levels of cAMP due to a compensatory up-regulation in phosphodiesterase activity. Interestingly, Gsalpha* transgenic mice also exhibit enhanced basal synaptic transmission. Consistent with a role for the cAMP/PKA pathway in learning and memory, Gsalpha* transgenic mice show impairments in spatial learning in the Morris water maze and in contextual and cued fear conditioning tasks. The learning deficits observed in these transgenic mice suggest that associative and spatial learning requires regulated Gsalpha protein signaling, much as does olfactory learning in Drosophila.     

Relationship between physical education students' achievements in a French badminton service test and expert ratings of technique quality

Assessment of practical skills in physical education lessons have often been criticised as subjective. In this study three experienced judges' ratings poorly predicted the 116 students' scores on the French badminton short service test.     

Relationships of Functional Flexibility with Individual and Work Factors

To investigate how functional flexibility is related to demographics, personality traits, and work perceptions, 250 employees of a large Dutch passenger transport firm filled out a written questionnaire. Two dimensions of functional flexibility were discerned: willingness and ability to be flexible. Analysis of variance showed the support staff and managers were higher on willingness and ability to be flexible than workers. Hierarchic regression analysis showed that willingness to be flexible was positively related to initiative and trust in management, and was negatively related to age and task formalization. Ability to be flexible was positively related to general self-efficacy and initiative, and was negatively related to task formalization. It was concluded that willingness to be flexible depends on fair treatment and freedom provided by their organization and that ability to be flexible is part of the development of general self-efficacy.     

The General Health Questionnaire and Eysenck's three-dimensional model of personality

A sample of 115 men and women between the ages of 20 and 60 completed the 30-item General Health Questionnaire together with the short-form Revised Eysenck Personality Questionnaire. The data indicate psychological distress so assessed is correlated .43 (p <.001) with Neuroticism and -.26 (p <.01) with Introversion but is unrelated to Psychoticism scores.     

A methodology for assessing the functions of emerging speech in children with developmental disabilities

An approach based on Skinner's (1957) theory of verbal behavior has been developed to understand and teach elementary communication skills to children with autism and developmental disabilities (Sundberg & Partington, 1998). However, few studies have directly examined the characteristics of emerging language in children with developmental disabilities. The purpose of this study was to develop and evaluate an assessment for identifying the elementary functions of vocal speech in children. Participants were 4 children with developmental disabilities, aged 6 years to 12 years, who exhibited at least one distinguishable vocal response (word or phrase) frequently in the natural environment. The assessment focused on three verbal operants delineated by Skinner (mand, tact, and intraverbal). One or more functions were identified for at least one vocal response of each child. Results suggested that this assessment would be useful for (a) evaluating Skinner's theory, (b) guiding decisions about language training for individual children, and (c) studying the nature of expressive language development in children with developmental disabilities.     

Evidence for an Error Monitoring Deficit in Attention Deficit Hyperactivity Disorder

We studied error monitoring in ADHD and control children in a task requiring inhibition of a motor response. The extent of slowing following successful (stopped) and failed (nonstopped) inhibition was compared across groups. We also measured the time required to inhibit a response (stop signal reaction time, SSRT). Compared to controls, ADHD participants slowed less following nonstopped responses. Slowing did not vary with comorbid reading, oppositional, conduct or anxiety disorder, sex or ADHD subtype. Slowing after nonstopped responses was marginally, although significantly correlated with total ADHD symptoms and with age. ADHD participants had significantly longer SSRT than controls, but SSRT was not significantly correlated with slowing. The apparent deficit in error monitoring in ADHD and its independence from the inhibition deficit observed in ADHD has implications for executive control models of ADHD, performance problems associated with the disorder and for component theories of executive control.     

Sex education sources and attitudes toward sexual precautions across a decade

75 college students responded to Moore and Barling's AIDS questionnaire. Coopersmith's Self-esteem Inventory, and a background survey regarding sex education and sexual and religious activity. The most commonly reported sources of sex education were peers, parents, and high school courses, respectively. Ratings of the most important of 10 potential sources of sex education included peers, high school courses, and religious institutions, respectively. None of these were significantly correlated with future condom use. Virgins reported more open communication with parents about sex. Sexual experience was positively related to more confusion about sexual precautions but negatively related to foreclosed attitudes toward such precautions. Some types of religious involvement (church attendance and campus religious organization membership) were related to foreclosed attitudes. Data in attitudinal and sex education were compared with data collected in 1991. Although students more frequently reported having received sex education in 2000, their attitudes toward utilizing sexual precautions have become somewhat more diffused.     

Psychological type and attitude toward Christianity: a replication

A sample of 149 university students completed the Francis Psychological Type Scales together with the Francis Scale of Attitude Toward Christianity. The data indicated that university students classified as Feeling Types hold a more positive attitude toward Christianity than those classified as Thinking Types. These findings replicate the 1999 report of Jones and Francis.     

The Relationship Between Personality and Satisfaction/Dissatisfaction with Ministry Among Female Stipendiary Anglican Clergy in the UK

A sample of 565 female stipendiary Anglican clergy in the UK completed the short form Revised Eysenck Personality Questionnaire together with indices of satisfaction with ministry and of dissatisfaction with ministry. The data demonstrate that satisfaction with ministry is associated with stable extraversion, while dissatisfaction with ministry is associated with toughminded neuroticism. Satisfaction and dissatisfaction with ministry are not opposite ends of the same continuum. Pastoral Theology and Mansel Jones Fellow at Trinity College