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41.
We studied human movement planning in tasks in which subjects selected one of two goals that differed in expected gain. Each goal configuration consisted of a target circle and a partially overlapping penalty circle. Rapid hits into the target region led to a monetary bonus; accidental hits into the penalty region incurred a penalty. The outcomes assigned to target and penalty regions and the spatial arrangement of those regions were varied. Subjects preferred configurations with higher expected gain whether selection involved a rapid pointing movement or a choice by key press. Movements executed to select one of two goal configurations exhibited the same movement dynamics as pointing movements directed at a single configuration, and were executed with the same high efficiency. Our results suggest that humans choose near-optimal strategies when planning their movement, and can base their selection of strategy on a rapid judgment about the expected gain associated with possible movement goals. 相似文献
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Computational modeling assists in analyzing the specific functional role of the cellular effects of acetylcholine within cortical structures. In particular, acetylcholine may regulate the dynamics of encoding and retrieval of information by regulating the magnitude of synaptic transmission at excitatory recurrent connections. Many abstract models of associative memory function ignore the influence of changes in synaptic strength during the storage process and apply the effect of these changes only during a so-called recall-phase. Efforts to ensure stable activity with more realistic, continuous updating of the synaptic strength during the storage process have shown that the memory capacity of a realistic cortical network can be greatly enhanced if cholinergic modulation blocks transmission at synaptic connections of the association fibers during the learning process. We here present experimental data from an olfactory cortex brain slice preparation showing that previously potentiated fibers show significantly greater suppression (presynaptic inhibition) by the cholinergic agonist carbachol than unpotentiated fibers. We conclude that low suppression of non-potentiated fibers during the learning process ensures the formation of self-organized representations in the neural network while the higher suppression of previously potentiated fibers minimizes interference between overlapping patterns. We show in a computational model of olfactory cortex, that, together, these two phenomena reduce the overlap between patterns that are stored within the same neural network structure. These results further demonstrate the contribution of acetylcholine to mechanisms of cortical plasticity. The results are consistent with the extensive evidence supporting a role for acetylcholine in encoding of new memories and enhancement of response to salient sensory stimuli. 相似文献
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Alan Maloney 《The Journal of analytical psychology》1999,44(1):101-116
Archetype Theory is consistent with the full range of empirical psychological research, yet has not itself been empirically studied. As part of a project to integrate psychological theory, especially psychotherapeutic theory, with empirical research, I asked 151 subjects to rate their preferences for images representing archetypal themes and factor analysed their responses. The results are consistent with the hypothesis that archetypal themes determine affective responses in adults. Archetype theory may prove itself to be useful in operationalizing a number of contemporary psychological theories. 相似文献
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We discuss behavioral studies directed at understanding how probability information is represented in motor and economic tasks. By formulating the behavioral tasks in the language of statistical decision theory, we can compare performance in equivalent tasks in different domains. Subjects in traditional economic decision-making tasks often misrepresent the probability of rare events and typically fail to maximize expected gain. By contrast, subjects in mathematically equivalent movement tasks often choose movement strategies that come close to maximizing expected gain. We discuss the implications of these different outcomes, noting the evident differences between the source of uncertainty and how information about uncertainty is acquired in motor and economic tasks. 相似文献
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The present experiments were conducted to develop a more sensitive and reliable model of stress-induced behavioral pathology in the mouse. Male mice were housed singly in nest cages connected to either a circular tunnel, a recreational cage or a large box with food foraging apparatus. Spontaneous nocturnal out of nest activity or food foraging behavior in these environments was continuously monitored for a two week period during which time the effects of stress were examined. It was found that both repeated restraint and aggression stress markedly and persistently reduced out of nest nocturnal activity or food foraging behavior in all 3 environments but did not alter activity in a novel open field or plus maze or food or saccharin intake in the nest cage. In a preliminary experiment the reduction in out of nest activity by stress was attenuated by prior chronic treatment with the antidepressant, desmethylimipramine. Plasma corticosterone was elevated immediately after aggression stress but reduced 5 hr after chronic aggression stress. The reduction in activity did not appear the result of increased anxiety as measured by spontaneous risk assessment behavior in the nest. It is concluded that the decrease in out of nest activity after stress in the present studies models a withdrawn behavioral state and may be due to either or both a decrease in appetitive motivation to leave the nest or an increased aversion to the external environment which does not apparently involve anxiety. 相似文献
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Yue Guan Kristin A. Maloney Debra L. Roter Toni I. Pollin 《Journal of genetic counseling》2018,27(3):608-615
The purpose of this study was to assess the informational content, readability, suitability and comprehensibility of websites offering educational information about monogenic diabetes available to patients. The top 20 results from 15 queries in four search engines were screened. Content analysis was performed by two independent coders. Readability was determined using Flesch-Kincaid grade level (FKGL) and Simplified Measure of Goobledygook (SMOG). The Comprehensibility Assessment of Materials (SAM + CAM) scale was utilized to evaluate website suitability and comprehensibility. Only 2% (N = 29) of 1200 screened websites met inclusion criteria. Content analysis showed that 16 websites presented information on at least the most common forms of MODY (1, 2 and 3), four addressed the utility of genetic counseling, and none included support resources for patients. All websites exceeded the consensus readability level (6th grade) as assessed by FKGL (10.1 grade) and SMOG (12.8 ± 1.5 grades). Although the majority (N = 20) of websites had an overall “adequate” to “superior” quality score (SAM + CAM score > = 40%), more than one-third scored “not suitable” in categories of content, literacy demand, graphics, and learning motivation. The online educational resources for monogenic diabetes have a high readability level and require improvement in ease of use and comprehensibility for patients with diabetes. 相似文献
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