Enhanced inhibitory avoidance learning prevents the long-term memory-impairing effects of cycloheximide,a protein synthesis inhibitor

Interference with activity of numerous cerebral structures produces memory deficiencies; in many instances, however, when animals are over-trained such interference becomes innocuous. Systemic administration of protein synthesis inhibitors impairs long-term retention; this effect has been interpreted to mean that protein synthesis is required for memory consolidation, though little is known about the effect of protein synthesis inhibitors on memory of enhanced learning in the rat. To further analyze the protective effect of enhanced learning against amnesic treatments, groups of Wistar rats were trained in a one-trial step-through inhibitory avoidance task, using different intensities of foot-shock during training. Cycloheximide (CXM; 2.8 mg/kg), an inhibitor of protein synthesis, was injected either 30 min before training or immediately after training. Twenty-four hours after training retention latencies were recorded. Our data showed that both pre- and post-training administration of CXM produced amnesia in those groups that had been trained with relatively low foot-shock intensities, but no impairment in retention was observed when relatively high intensities of foot-shock were administered. These and similar results lead us to conclude that protein synthesis inhibitors may interfere with memory consolidation, but their effect disappears when animals are submitted to an enhanced learning experience, calling into question the idea that protein synthesis is required for memory consolidation.     

Mechanisms underlying the self-talk–performance relationship: The effects of motivational self-talk on self-confidence and anxiety

ObjectivesThe present study examined the effects of motivational self-talk on self-confidence, anxiety, and task performance in young athletes.MethodsParticipants were 72 tennis players. The experiment was conducted in five sessions: baseline assessment, three training sessions, and final assessment. After the baseline assessment participants were divided and assigned randomly into experimental and control groups. The two groups followed the same training program with the experimental group practicing the use of self-talk. In the last session, the final assessment took place. A forehand drive test was used to evaluate task performance, and the Competitive Anxiety Inventory-2R was used to assess self-confidence and anxiety.ResultsA two-way mixed model MANOVA revealed that task performance improved for the experimental group (p < .01) and remained stable for the control group; self-confidence increased (p < .01) and cognitive anxiety decreased (p < .05) for the experimental group, whereas no changes were observed for the control group. Correlation analysis revealed that changes in task performance were moderately related to changes in self-confidence (p < .05).ConclusionsThe results of the study showed that self-talk can enhance self-confidence and reduce cognitive anxiety. Furthermore, it is suggested that increases in self-confidence can be regarded as a viable function explaining the facilitating effects of self-talk on performance.     

Stroop effects on redemption and semantic effects on confession: simultaneous automatic activation of embedded and carrier words

The present study was aimed at assessing whether focusing attention on a task-relevant part of a word prevents processing of its meaning. Participants performed a color-naming task on a prime word followed by lexical decision on a probe. Primes were words, which could contain an embedded color word (e.g., “redemption”) written in an incongruent color. Probes were either semantically related (e.g., “confession”) or unrelated (e.g., “production”) to the prime word. A Stroop effect emerged for color words appearing either in the initial or in the final position of the carrier word. A priming effect also emerged, with faster responses to probes semantically related to the prime. These results are evidence that focusing attention on part of a prime (i.e., the embedded color word) does not prevent the semantic processing of the entire word.     

Can tutoring improve performance on a reasoning task under deadline conditions?

The present study examined the effectiveness of a tutoring technique that has been used to identify and address participants' misunderstandings in Wason's selection task. In particular, the study investigated whether the technique would lead to improvements in performance when the task was presented in a deadline format (a condition in which time restrictions are imposed). In Experiment 1, the effects of tutoring on performance were compared in free time (conditions in which no time restrictions are imposed) and deadline task formats. In Experiment 2, improvements in performance were studied in deadline task formats, in which the tutoring and test phases were separated by an interval of 1 day. The results suggested that tutoring improved performance on the selection task under deadline and in free time conditions. Additionally, the study showed that participants made errors because they had misinterpreted the task. With tutoring, they were able to modify their initial misunderstandings.     

Pre-training to find a hidden platform in the Morris water maze can compensate for a deficit to find a cued platform in a rat model of Parkinson's disease

The bilateral intranigral infusion of 1 micromol 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in adult male Wistar rats caused a specific and partial loss of substantia nigra pars compacta (SNc) dopamine neurons, a partial depletion of striatal dopamine, and a deficit to learn the intra-maze cued version of the Morris water maze. Pre-training the SNc rats in the spatial version of the water maze or simply maintaining the animals on the water maze platform reversed this deficit. This improvement was even observed when the order of the extra-maze cues presented to the rats during pre-training of the spatial version was changed during training of the intra-maze cued version. However, this deficit was not reversed either by maintaining the animals on the platform if the spatial cues were surrounded and covered with a curtain or by swimming sessions in the maze without the escape platform and the curtain. These findings suggest that none of the following elements alone, learned during the spatial task pre-training, could help SNc rats learn the intra-maze cued task: improvement of swimming skills or knowledge of the existence of the escape platform; distance between the platform and the border of the pool; location of a particular extra-maze cue; relations among extra-maze cues. However, the simultaneous presence of the escape platform and extra-maze cues (irrespective of their relational configuration) during the pre-training sessions proved to be necessary for this improving effect to occur.     

Metacognitive Interpersonal Therapy Improves Adherence to Antiretroviral Therapies in a Man with a Severe Personality Disorder: A Case Report

Treatment adherence by patients with HIV ensures they gain the full benefit of antiretroviral medications and extend their lives. One problem which may contribute to poor adherence is deficits in metacognition or the capacity to make sense of mental states. In particular, persons who struggle to notice and think about their thoughts and feelings may be less able to direct their own recovery by taking advantage of effective treatments. This raises the possibility that treatments which lead to improved metacognitive function may enhance treatment adherence. We describe the case of a man in an advanced stage of AIDS with Kaposi’s sarcoma. The patient was treated with Metacognitive Interpersonal Therapy combined with psychoeducation about pharmacological treatment for HIV. Primary medical outcomes were suppression of viral load, increase of CD4 count and control of AIDS related conditions such as Kaposi’s sarcoma. The primary psychological outcome was reduction of personality disorders criteria. The patient was able to understand what led him to discontinue medication and then later regain full adherence. He achieved suppression of viral load and restore of CD4 count. As regard severity of personality disorder, he achieved reliable change. Interventions such as Metacognitive Interpersonal Therapy may assist patients with HIV to gain the metacognitive capacities to make sense of their medical and psychological challenges and adhere to antiretroviral therapies leading to enhanced levels of health. Future studies are needed to explore these findings in larger controlled studies.