幽门螺杆菌根除失败原因及补救策略分析

幽门螺杆菌(Hp)与胃炎、消化性溃疡、胃黏膜相关淋巴组织淋巴瘤及胃癌关系密切.随着根除Hp治疗在临床的普遍开展,Hp根除率逐渐下降,其主要原因是日益突出的抗生素耐药及患者对药物依从性差.对根除治疗失败者进行补救治疗已成为Hp治疗研究领域的新热点.由于各地的HP耐药率及感染者个体情况存在很大差异.目前尚未形成统一规范的补救策略,遵循个体化的补救策略已逐渐被大家所接受.     

Origins of the stuttering stereotype: stereotype formation through anchoring-adjustment

The stereotype of people who stutter is predominantly negative, holding that stutterers are excessively nervous, anxious, and reserved. The anchoring–adjustment hypothesis suggests that the stereotype of stuttering arises from a process of first anchoring the stereotype in personal feelings during times of normal speech disfluency, and then adjusting based on a rapid heuristic judgment. The current research sought to test this hypothesis, elaborating on previous research by [White, P. A., & Collins, S. R. (1984). Stereotype formation by inference: A possible explanation for the “stutterer” stereotype. Journal of Speech and Hearing Research, 27, 567–570]. Participants provided ratings of a hypothetical typical person who stutters, a person suffering from normal speech disfluency and a typical male on a 25-item semantic differential scale. Results showed a stereotype of people who stutter similar to that found in previous research. The pattern of results is consistent with the anchoring–adjustment hypothesis. Ratings of a male stutterer are very similar to a male experiencing temporary disfluency, both of which differ from ratings of a typical male. As expected, ratings of a stutterer show a small but statistically significant adjustment on several traits that makes the stereotype of stutterers less negative and less emotionally extreme than the temporarily disfluent male. Based on the results of this research, it appears that stereotype formation is a result of generalization and adjustment from personal experience during normal speech disfluency.

Educational objectives: The reader will be able to: (1) explain how the negative stereotype of people who stutter arises; (2) discuss the negative implications of stereotypes in the lives of people who stutter; and (3) summarize why the stereotype of people who stutter is so consistent and resistant to change.     

Improving eyewitness recall for licence plates

Two methods for maximizing the completeness and accuracy of eyewitness recall for licence plates were evaluated in this research: (1) asking questions derived from generally accepted principles of memory retrieval enhancement (Geiselman, Fisher, Firstenberg, Hutton, Sullivan, Avetissian and Prosk, 1984; Geiselman, Fisher, MacKinnon and Holland, 1985, 1986) and (2) providing subjects with a licence plate simulation device to view and interchange alphanumeric characters. Undergraduate subjects viewed a series of slides portraying a young man, placing a television set in a car and driving down the street. With a seven-character California plate in Experiment 1 (n = 151), subjects in the condition with the simulation device and cognitive interviewing had a significant 22 per cent increase in correct licence plate recall. The results were replicated in Experiment 2 (n = 108) with an 18 per cent increase in correct information using a six-character plate. Errors appeared to be those letters adjacent in the alphabet to the licence plate letters.     

Mediating mechanisms in a school-based drug prevention program: first-year effects of the Midwestern Prevention Project

Describes (a) the effects of a social-influences-based drug prevention program (the Midwestern Prevention Project) on the mediating variables it was designed to change and (b) the process by which the effects on mediating variables changed use of drugs (tobacco, alcohol, and marijuana). Students in 42 middle schools and junior high schools in Kansas City, Missouri, and Kansas City, Kansas, were measured in the fall of 1984 (N = 5,065) and again 1 year later (N = 5,008) after 24 of the schools had been through the program. Compared to students in control schools, students in program schools became less likely to express belief in the positive consequences of drug use, less likely to indicate that they would use such drugs in the future, more likely to report that their friends were less tolerant of drug use, and more likely to believe that they were better able to communicate with their friends about drug or school problems. Change in perceptions of friends' tolerance of drug use was the most substantial mediator of program effects on drug use. There was evidence that intentions to use and beliefs about the positive consequences of use may also mediate program effects on drug use.     

智能时代的工程心理学

智能技术为智能时代的工程心理学研究和应用提供了新的机遇。为此, 系统提出了智能时代工程心理学的工作框架。该工作框架包括工程心理学研究和应用的对象、核心问题空间、学科理念、研究重点、应用范围、方法等。智能时代的人机关系呈现出一种新的形式: 人机组队式的人机合作关系。“以人为中心的人工智能”应该是智能时代工程心理学的学科理念。针对智能技术, 近期工程心理学研究者开始开展围绕新型人机关系的理论框架和基本问题、人机组队中的心理结构和决策控制、人机交互等方面的研究工作。为有效支持智能系统的研发, 概括总结了一些工程心理学新方法和提升的方法。最后, 针对当前工程心理学所面对的一些挑战提出了具体的建议。     

孔子思想中的君子人格：心理学测量的探索

君子人格是中国文化(尤其是儒学思想)中的理想的人格特质, 对于理解中国文化心理具有重要意义, 但鲜有实证研究。通过经典文本的理论分析与心理测量的实证分析相结合的方法, 选取《论语》中孔子对君子的论述编制初测条目, 通过探索性和验证性因素分析、效标关联效度分析等实证研究方法(总样本量 = 1916), 对孔子思想中的君子人格的内在结构进行了探索, 并编制了具有良好信效度的测量工具。结果表明, 孔子思想中的君子人格包含了智仁勇、恭而有礼、喻义怀德、有所不为、持己无争5个因素。此外还考察了其与大五人格、中国人价值观、自我和谐、合作与竞争人格倾向、亲社会倾向等效标变量的相关关系。     

Guidelines for the Investigation of Mediating Variables in Business Research

Business theories often specify the mediating mechanisms by which a predictor variable affects an outcome variable. In the last 30 years, investigations of mediating processes have become more widespread with corresponding developments in statistical methods to conduct these tests. The purpose of this article is to provide guidelines for mediation studies by focusing on decisions made prior to the research study that affect the clarity of conclusions from a mediation study, the statistical models for mediation analysis, and methods to improve interpretation of mediation results after the research study. Throughout this article, the importance of a program of experimental and observational research for investigating mediating mechanisms is emphasized.     

Multilevel mediation analysis: The effects of omitted variables in the 1–1–1 model

Multilevel mediation analysis examines the indirect effect of an independent variable on an outcome achieved by targeting and changing an intervening variable in clustered data. We study analytically and through simulation the effects of an omitted variable at level 2 on a 1–1–1 mediation model for a randomized experiment conducted within clusters in which the treatment, mediator, and outcome are all measured at level 1. When the residuals in the equations for the mediator and the outcome variables are fully orthogonal, the two methods of calculating the indirect effect (ab, c – c′) are equivalent at the between‐ and within‐cluster levels. Omitting a variable at level 2 changes the interpretation of the indirect effect and will induce correlations between the random intercepts or random slopes. The equality of within‐cluster ab and c – c′ no longer holds. Correlation between random slopes implies that the within‐cluster indirect effect is conditional, interpretable at the grand mean level of the omitted variable.