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排序方式: 共有226条查询结果,搜索用时 15 毫秒
111.
Cheng RK MacDonald CJ Williams CL Meck WH 《Learning & memory (Cold Spring Harbor, N.Y.)》2008,15(3):153-162
Choline availability in the maternal diet has a lasting effect on brain and behavior of the offspring. To further delineate the impact of early nutritional status, we examined effects of prenatal-choline supplementation on timing, emotion, and memory performance of adult male and female rats. Rats that were given sufficient choline (CON: 1.1 g/kg) or supplemental choline (SUP: 5.0 g/kg) during embryonic days (ED) 12-17 were trained with a differential reinforcement of low-rate (DRL) schedule that was gradually transitioned through 5-, 10-, 18-, 36-, and 72-sec criterion times. We observed that SUP-females emitted more reinforced responses than CON-females, which were more efficient than both groups of males. In addition, SUP-males and SUP-females exhibited a reduction in burst responding (response latencies <2 sec) compared with both groups of CON rats. Furthermore, despite a reduced level of burst responding, the SUP-males made more nonreinforced responses prior to the DRL criterion as a result of maintaining the previous DRL criterion following transition to a new criterion. In summary, long-lasting effects of prenatal-choline supplementation were exhibited by reduced frustrative DRL responding in conjunction with the persistence of temporal memory in SUP-males and enhanced temporal exploration and response efficiency in SUP-females. 相似文献
112.
MacDonald KB 《Psychological review》2008,115(4):1012-1031
This article analyzes the effortful control of automatic processing related to social and emotional behavior, including control over evolved modules designed to solve problems of survival and reproduction that were recurrent over evolutionary time. The inputs to effortful control mechanisms include a wide range of nonrecurrent information--information resulting not from evolutionary regularities but from explicit appraisals of costs and benefits. Effortful control mechanisms are associated with the ventromedial prefrontal cortex and the ventral anterior cingulated cortex. These mechanisms are largely separate from mechanisms of cognitive control (termed executive function) and working memory, and they enable effortful control of behavior in the service of long range goals. Individual differences in effortful control are associated with measures of conscientiousness in the Five Factor Model of personality. Research in the areas of aggression, ethnocentrism, sexuality, reward seeking, and emotion regulation is reviewed indicating effortful control of automatic, implicit processing based on explicit appraisals of the context. Evidence is reviewed indicating that evolutionary pressure for cooperation may be a critical adaptive function accounting for the evolution of explicit processing. 相似文献
113.
Antidepressants, in particular newer agents, are among the most widely prescribed medications worldwide with annual sales
of billions of dollars. The introduction of these agents in the market has passed through seemingly strict regulatory control.
Over a thousand randomized trials have been conducted with antidepressants. Statistically significant benefits have been repeatedly
demonstrated and the medical literature is flooded with several hundreds of "positive" trials (both pre-approval and post-approval).
However, two recent meta-analyses question this picture. The first meta-analysis used data that were submitted to FDA for
the approval of 12 antidepressant drugs. While only half of these trials had formally significant effectiveness, published
reports almost ubiquitously claimed significant results. "Negative" trials were either left unpublished or were distorted
to present "positive" results. The average benefit of these drugs based on the FDA data was of small magnitude, while the
published literature suggested larger benefits. A second meta-analysis using also FDA-submitted data examined the relationship
between treatment effect and baseline severity of depression. Drug-placebo differences increased with increasing baseline
severity and the difference became large enough to be clinically important only in the very small minority of patient populations
with severe major depression. In severe major depression, antidepressants did not become more effective, simply placebo lost
effectiveness. These data suggest that antidepressants may be less effective than their wide marketing suggests. Short-term
benefits are small and long-term balance of benefits and harms is understudied. I discuss how the use of many small randomized
trials with clinically non-relevant outcomes, improper interpretation of statistical significance, manipulated study design,
biased selection of study populations, short follow-up, and selective and distorted reporting of results has built and nourished
a seemingly evidence-based myth on antidepressant effectiveness and how higher evidence standards, with very large long-term
trials and careful prospective meta-analyses of individual-level data may reach closer to the truth and clinically useful
evidence. 相似文献
114.
Suzanne E. MacDonald Marcia L. Spetch Debbie M. Kelly Ken Cheng 《Learning and motivation》2004,35(4):484-347
Common marmosets (Callithrix jacchus jacchus), human children, and human adults learned to find a goal that was located in the center of a square array of four identical landmarks. The location of the landmark array and corresponding goal varied across trials, so the task could not be solved without using the landmark array. In Experiment 1, a matrix of discrete goal locations was presented and the landmarks surrounded and were adjacent to the correct location during training. After training, an expansion test was given in which the distance between landmarks was increased. Marmosets, children (ages 5–9), and adults all readily learned to use the landmarks to search accurately during training. On the expansion test, adults uniformly searched in the center of the array. Monkeys and children concentrated their searching near the landmarks rather than in the center. The monkeys, but not the children, searched more often on the directionally appropriate side of the landmarks than on other sides of the landmarks. In Experiment 2, children (ages 3–5) were trained with a continuous search space and with the goal farther from the landmarks so that a beaconing strategy rule could not be used. Several of the children failed to acquire the training task. Of those who learned to find the goal, three searched in the middle on expansion tests but most searched nearer to the landmarks. The “middle rule” strategy that is uniformly used by adult humans does not appear to be a preferred strategy for children or non-human primates. 相似文献
115.
Matthew T. McCrudden Ashleigh Barnes Erin M. McTigue Casey Welch Eilidh MacDonald 《Thinking & reasoning》2017,23(2):115-133
This study investigated whether perspective-taking reduces belief bias independently of argument strength. Belief bias occurs when individuals evaluate belief-consistent arguments more favourably than belief-inconsistent arguments. Undergraduates (n = 93) read arguments that varied with respect to belief-consistency (i.e., belief-consistent or belief-inconsistent) and strength (i.e., strong or weak) about the topic of climate change. After participants read each argument, those in the perspective-taking condition rated the argument's strength from a perspective of a climate scientist and then from their own perspectives, whereas those in the no perspective-taking condition only rated the arguments from their own perspectives. Perspective-taking eliminated belief bias for weak arguments, but not for strong arguments. Theoretical and practical implications of the results are discussed, and directions for future research are provided. 相似文献
116.
Anxious attachment predicts strong desires for intimacy and stability in romantic relationships, yet the relation between anxious attachment and romantic commitment is unclear. We propose that extant literature has failed to find a consistent relation because anxiously attached individuals experience conflicting pressures on commitment. Data from Australia (N=137) show that relationship satisfaction and felt security each act as suppressors of a positive relation between anxious attachment and commitment. Data from Japan (N=159) replicate the suppression effect of felt security and also demonstrate that the residual positive relation between anxious attachment and commitment can be partly explained by dependence on the partner. These findings suggest that anxiously attached individuals may be ambivalent about commitment. Dissatisfaction and worries about negative evaluation appear to exert downward pressure on commitment, counteracting the upward pressure that is exerted by factors such as relational dependency. 相似文献
117.
Cornman DH Christie S Shepherd LM MacDonald S Amico KR Smith LR Shuper PA Adelaja A Mahlase G Fröhlich JA Pillay S Lalloo UG Fisher WA Fisher JD 《Psychology & health》2011,26(12):1623-1641
This study developed an HIV risk reduction intervention for people living with HIV (PLWH) obtaining care at primary healthcare clinics in KwaZulu-Natal, South Africa by (1) conducting elicitation research to understand the dynamics of risk behaviour among PLWH, (2) modifying an existing HIV risk reduction intervention based on research findings and (3) conducting a pilot study to evaluate feasibility, acceptability and fidelity of the modified intervention implemented by trained lay counsellors at a rural clinic in KwaZulu-Natal. A total of 61 healthcare providers and 77 HIV+ patients from four primary healthcare clinics participated in 14 focus groups and 20 individual interviews to identify informational, motivational and behavioural skills (IMB) factors contributing to PLWH's sexual risk behaviour. Elicitation research findings were incorporated into a revised version of Options for Health, an evidence-based risk reduction intervention for PLWH in clinical care. In a 5-day training, lay counsellors learned strategies to address IMB barriers to safer sex identified in elicitation research. The revised intervention, which was implemented by six counsellors with 39 patients, was feasible to implement, acceptable to patients and counsellors, and implemented with good fidelity. This study makes an important contribution towards development of a theory-based HIV risk reduction intervention for PLWH linking prevention with treatment in South Africa. 相似文献
118.
MacDonald DA 《Journal of personality》2000,68(1):153-197
The present article focused on the development and measurement of a factor model of the expressions of spirituality. Study 1 (N = 534) involved the use of factor analysis to examine the latent factor structure in a sample of 11 measures of spiritual constructs. Study 2 (N = 938) focused on the replication of Study 1 results and on the construction and initial validation of an instrument to operationalize the factor model of spirituality. Results indicate that at least 5 robust dimensions of spirituality underlie the spirituality test domain. These dimensions were labeled Cognitive Orientation Towards Spirituality (COS), Experiential/Phenomenological Dimension (EPD), Existential Well-Being (EW-B), Paranormal Beliefs (PAR), and Religiousness (REL). The measure developed, named the Expressions of Spirituality Inventory (ESI), takes the form of a 98-item instrument that generated scores demonstrating satisfactory reliability and adequate initial validity. Examination of the relation of spirituality to the Five Factor Model (FFM) as measured by the NEO Personality Inventory-Revised revealed that the dimensions of the FFM appear to differentially relate to the major elements of spirituality but are nevertheless conceptually unique, pointing to the possible existence of major aspects of personality not represented in the FFM. 相似文献
119.
Investigating a memory-based account of negative priming: support for selection-feature mismatch 总被引:5,自引:0,他引:5
MacDonald PA Joordens S 《Journal of experimental psychology. Human perception and performance》2000,26(4):1478-1496
Using typical and modified negative priming tasks, the selection-feature mismatch account of negative priming was tested. In the modified task, participants performed selections on the basis of a semantic feature (e.g., referent size). This procedure has been shown to enhance negative priming (P. A. MacDonald, S. Joordens, & K. N. Seergobin, 1999). Across 3 experiments, negative priming occurred only when the repeated item mismatched in terms of the feature used as the basis for selections. When the repeated item was congruent on the selection feature across the prime and probe displays, positive priming arose. This pattern of results appeared in both the ignored- and the attended-repetition conditions. Negative priming does not result from previously ignoring an item. These findings strongly support the selection-feature mismatch account of negative priming and refute both the distractor inhibition and the episodic-retrieval explanations. 相似文献
120.