瓜蒌皮与前列地尔预处理对心肌缺血再灌注的影响

探讨瓜蒌皮和前列地尔预处理对心肌缺血再灌注的作用机制.通过建立SD大鼠心肌缺血再灌注的模型,采用Tunel法检测组织样本细胞凋亡和免疫组化法检测bax,bcl-2,caspase-3的蛋白表达情况进行研究.结果显示,瓜蒌皮和前列地尔半剂量联合组的凋亡细胞数、Bax和caspase-3的蛋白表达量较其他各实验组均明显降低,Bcl-2的表达量升高,且有统计学意义(P＜0.05);瓜蒌皮单用药组也表现为凋亡细胞数、Bax和caspase-3的表达量降低,Bcl-2的表达量升高,但程度不如两组联合用药组.实验可以证明细胞凋亡发生在心肌缺血/再灌注损伤中,瓜蒌皮可对心肌缺血/再灌注起保护作用,并且与前列地尔联合后更有利于对心肌细胞的保护作用.     

A Systematic Review of the Relationship Between Rumination and Suicidality

Rumination has been persistently implicated in the etiology of hopelessness and depression, which are proximal predictors of suicidality. As a result, researchers have started to examine the role of rumination in suicidality. This systematic review provides a concise synopsis of the current progress in examining the relationship between rumination and suicidality, and highlights areas for future research. A search of the international literature was conducted using the three main psychological and medical databases. Eleven studies were identified providing evidence, with one exception, of a relationship between rumination and suicidality. This review also highlights the considerable dearth of studies on this area of concern, specifically of case‐control and prospective, clinical studies, in the worldwide literature.     

Treating the Capability for Suicide: A Vital and Understudied Frontier in Suicide Prevention

Current efforts at suicide prevention center largely on reducing suicidal desire among individuals hospitalized for suicidality or being treated for related psychopathology. Such efforts have yielded evidence‐based treatments, and yet the national suicide rate has continued to climb. We propose that this disconnect is heavily influenced by an unmet need to consider population‐level interventions aimed at reducing the capability for suicide. Drawing on lessons learned from other public health phenomena that have seen drastic declines in frequency in recent decades (HIV, lung cancer, motor vehicle accidents), we propose that current suicidality treatment efforts trail current suicidality theories in their lack of focus on the extent to which individuals thinking about suicide are capable of transitioning from ideation to attempt. We summarize extant evidence for specific capability‐centered approaches (e.g., means safety) and propose other options for improving our ability to address this largely overlooked variable. We also note that population‐level approaches in this regard would represent an important opportunity to decrease risk in individuals who either lack access to evidence‐based care or underreport suicidal ideation, as a reduced capability for suicide would theoretically diminish the potency of suicidal desire and, in this sense, lower the odds of a transition from ideation to attempt.     

Does Reintegration Stress Contribute to Suicidal Ideation Among Returning Veterans Seeking PTSD Treatment?

Although posttraumatic stress disorder (PTSD) and other psychiatric symptoms are well‐established risk factors for suicidal ideation among returning veterans, less attention has been paid to whether the stress of reintegrating into civilian society contributes to suicidal ideation. Utilizing a sample of 232 returning veterans (95% male, mean age = 33.63 years) seeking PTSD treatment, this study tested whether reintegration difficulties contribute to suicidal ideation over and above the influence of PTSD symptoms, depression symptoms, and potential substance misuse. Logistic regressions indicated that reintegration stress had a unique effect on suicidal ideation over and above PTSD and depression symptoms. Reintegration stress interacted with substance misuse to predict suicidal ideation, such that the effect of reintegration stress on suicidal ideation was much larger for those with potential substance misuse. Exploratory analyses also examined which types of reintegration difficulties were associated with suicidal ideation, and found that difficulty maintaining military friendships, difficulty getting along with relatives, difficulty feeling like you belong in civilian society, and difficulty finding meaning/purpose in life were all significantly associated with suicidal ideation, beyond the effects of psychiatric symptoms and potential substance misuse. Findings highlight the importance of addressing reintegration stress for the prevention of suicide among returning veterans. Implications for treatment are discussed.     

Childhood Abuse,Nonsuicidal Self‐Injury,and Suicide Attempts: An Exploration of Gender Differences in Incarcerated Adults

The relationship between types of childhood abuse, suicide attempts, and nonsuicidal self‐injury (NSSI) was examined in a sample of 415 incarcerated adults (268 men, 147 women). Men and women were equally likely to experience childhood abuse, although women were more likely to report sexual abuse and men were more likely to report emotional neglect. Sexual abuse was the only type of abuse found to predict NSSI and suicide attempts in women. For men, physical abuse and physical neglect were significant predictors of NSSI and suicide attempts, respectively. Gender differences exist and should be examined in future research in this area.     

尼可地尔与前列地尔预处理对大鼠心肌缺血再灌注的影响

研究尼可地尔、前列地尔及两药物联合应用预处理对心肌缺血再灌注中的影响,探究其作用机制.采用Tunel法检测心肌组织的凋亡情况,免疫组化法检测Bax、Bcl-2和caspase-3的蛋白表达情况.结果显示尼可地尔和前列地尔半剂量联合组细胞凋亡数、Bax和caspase-3的表达量均明显低于其他给药组(P＜0.05),Bcl-2的表达量明显高于其他给药组(P＜0.05);尼可地尔和前列地尔单给药组细胞凋亡、Bax、caspase-3表达均有降低,Bcl-2表达升高,但效果不及联合用药半剂量组.以此得出结论尼可地尔和前列地尔的联合用药效果较好,可加强对心肌的保护作用.