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291.
Wistar rats of three age groups were tested in an automated tunnel-maze system of variable geometry to investigate whether changes in spontaneous locomotor activity and in learning and memory develop differentially or in a correlated fashion as a function of age. Senescent (30 months) as well as mature-adult (17 months) rats showed an age-correlated decline of locomotor activity as compared to the mature-young (5 months) group. Both working-memory (measured as within-trial arm discrimination performance) and reference-memory (measured as avoidance of "blind alley" visits) were severely affected in the senescent group, whereas the middle-aged animals suffered only from a working-memory deficit. The findings provide evidence that locomotor deficits do not necessarily interfere in the assessment of age-related changes in cognitive performance. Furthermore the results support the hypothesis that working and reference memory have different underlying physiological correlates and that these neuronal systems are differentially affected by the aging process. 相似文献
292.
Serotonergic and opiate interactions in the modulation of drug- and environmental-induced analgesia were assessed in 6-day-old Sprague-Dawley-derived rat pups using tail-flick testing procedures. In these experiments the serotonergic antagonist metergoline was observed to attenuate both the analgesia induced by the opiate agonist morphine and the analgesia induced by isolation from siblings and the dam, an environmental manipulation which has previously been shown to be associated with increases in opiate activity. In contrast, the opiate antagonist naloxone was observed to be ineffective in blocking not only analgesia induced by the serotonergic agonist quipazine, but also analgesia induced by long-term deprivation from the dam and food, a manipulation that has been previously reported to induce increases in serotonergic utilization. These results suggest that in the neonate, as in the adult, the serotonergic modulation of nociception appears to occur "downstream" from the opiate systems serving to regulate nociception following both drug- and environmental-induced alterations in pain sensitivity. Analgesia induced by long-term deprivation from food and the dam appears to be strongly related to increases in serotonergic activity and relatively unaffected by opiate antagonism, whereas analgesia induced by isolation from siblings and the dam may be related to increases in opiate activity, but modulated by serotonergic systems serving to regulate pain responsivity. Thus alterations in the environment, mediated at least in part by alterations in opiate and serotonergic activity, appear to play an important role in influencing the sensitivity of the neonate to pain stimuli. 相似文献
293.
The ability of right-brain-damaged (RBD) subjects to correctly insert a word into a well-formed stimulus sentence was tested. Subjects also performed three evaluative tasks designed to establish their degree of general cognitive impairment. The performance of RBD subjects on these tasks was compared to that of left-brain-damaged (LBD) and non-brain-damaged (NBD) subjects. Although RBD subjects outperformed LBD subjects on the language-related evaluative tasks, the RBD group was significantly more impaired on a subset of the insertion task. This subset included items which required reassignment of the syntactic status of elements in the stimulus sentence in order for the insertion to be carried out. The results of this study permit refinement of the common characterization of RBD individuals as rigid in their interpretation of meaning and indicate right-hemisphere involvement in aspects of the grammar previously thought to be inaccessible to it. 相似文献
294.
M J Nissen J L Ross D B Willingham T B Mackenzie D L Schacter 《Brain and cognition》1988,8(1):117-134
We studied an individual with multiple personality disorder in whom each of several personalities claimed to have no direct awareness of the others and to be unable to consciously remember the experiences of other personalities. A broad selection of implicit and explicit memory tests was used to determine the extent to which one personality had access to knowledge acquired by another and the circumstances in which that knowledge would be expressed. The implicit assessment of memory was a necessary but not sufficient condition for demonstrating interpersonality access. The degree of compartmentalization of knowledge in this patient depended largely on whether the interpretation of presented information was likely to differ across personalities. 相似文献
295.
Assessment of methods for measuring social support 总被引:2,自引:0,他引:2
A rapidly expanding literature documents the effects of social support on physical and psychological well-being. Although definitions vary, most include both tangible components (e.g., financial assistance and physical aid) and intangible components (e.g., encouragement and guidance). Social support has been implicated in the mediation of stressful life events, recovery from illness, and increased program adherence. There are many inconsistent findings in the literature, however, and it is difficult to resolve discrepancies because measures of social support vary widely from study to study. To guide in the selection of measurement methods for research and applied work, 23 techniques for assessing social support are reviewed and evaluated. Criteria for favorable evaluation included reliability coefficients greater than .8 and documentation of validity. Correlations between various social support and criterion measures are simulated in order to demonstrate the consequences of choosing a measure with low reliability. Scale developers reported reliability data for 19 of the reviewed measures. Internal consistency coefficients ranged from .31 to .98. Test-retest coefficients ranged from .22 to .96. At least some validity documentation was available for 13 of the scales. Discriminant validity evidence, however, is almost universally absent. Despite psychometric weaknesses and variability among the scales, researchers have several instruments available to them. 相似文献
296.
Knowledge and beliefs regarding the consequences of cigarette smoking and their relationships to smoking status in a biracial sample 总被引:3,自引:0,他引:3
R C Klesges G Somes R W Pascale L M Klesges M Murphy K Brown E Williams 《Health psychology》1988,7(5):387-401
The purpose of this investigation was to evaluate carefully smoking-related knowledge and beliefs and their relationships to smoking status in a large, heterogeneous sample of smokers and nonsmokers in two settings: (a) a large, biracial southern city and (b) a small midwestern community. Participants were 611 (198 male, 413 female) adult respondents to a random-dialing telephone survey in Fargo, North Dakota (n = 200), and Memphis, Tennessee (n = 411). Each participant was given the Smoking Attitudes Survey, which assesses generalized health beliefs as well as health-related problems associated with smoking. Participants' knowledge of smoking-associated diseases (e.g., lung cancer) and of diseases not associated with smoking (e.g., kidney stones) was assessed. Stepwise regression analysis of composite knowledge scores revealed four independent predictors of the health consequences of smoking: education, race, smoking status, and income. Smokers, compared to nonsmokers, reported less knowledge related to the health consequences of smoking, were more likely to be male, were less concerned with the health consequences of smoking, and were more concerned about the health consequences of cholesterol. The best predictor of smokers who had never attempted cessation was their greater concern over weight control when compared to smokers with a history of smoking cessation attempts. The results are discussed in terms of smoking prevention and intervention efforts. 相似文献
297.
The hypothesis that physical exercise provides benefits to individuals under periods of life stress has rarely been subject to empirical verification. This article presents the results of a longitudinal study of stress and well-being in adolescence in which the ability of exercise to buffer stress-induced deteriorations in physical health was examined. In accordance with predictions, prospective analyses revealed that the negative impact of stressful life events on health declined as exercise levels increased. These findings suggest that exercise may be a valuable resource for combating life stress. Discussion centers on possible mediating mechanisms and on the practical implications of the results. 相似文献
298.
Studies of psychosocial influences on coronary artery atherogenesis in cynomolgus monkeys 总被引:1,自引:0,他引:1
The cynomolgus macaque provides a suitable primate model for studying how psychosocial factors contribute to coronary artery atherogenesis. Important interactions with diet, sex, and behaviorally elicited cardiovascular reactivity are described. 相似文献
299.
Smoking, caffeine, and stress: effects on blood pressure and heart rate in male and female college students 总被引:2,自引:0,他引:2
This study examined the independent and joint effects of cigarette smoking and caffeine consumption on blood pressure (BP) and heart rate (HR) reactions to stress in male and female college students. Following an initial physiological baseline, participants received one of four experimental treatments (paced smoking, caffeine, smoking plus caffeine, or neither) and had BP and HR measured before, during, and after two stressful tasks. The results revealed that, compared with the control condition, caffeine ingestion enhanced the magnitude of stress-induced systolic BP and HR reactions. Smoking combined additively with stress, and the joint effect of smoking and caffeine was no greater than either taken alone. Males and females were generally similar in their BP and HR responses to smoking, caffeine, and stress. Inconsistencies with previous research and possible physiological mechanisms underlying the observed effects are discussed. 相似文献
300.
The vocationally-indecisive individual presents a major counselling problem. The theory and research behind career indecision is discussed and a counselling approach based on identity formation is outlined. Four identity statuses — Identity Achievements, Foreclosures, Identity Diffusions, and Moratoriums — are described and counselling approaches for each are explored. 相似文献