Offering predictive testing for Huntington disease in a medical genetics clinic: Practical applications

Predictive testing for Huntington disease is presently offered in a select few medical genetics centers in the United States. This is in part due to the labor intensive counseling and psychological testing suggested by the research protocols. We discuss some specific suggestions for establishing programs for Huntington disease predictive testing within pre-existing medical genetics clinics to encourage more centers to offer presymptomatic testing. This will allow more at risk individuals the opportunity to consider predictive testing and cut down the expenses of traveling to the few predictive testing centers that currently exist. The counseling principals will remain similar to those discussed here, even following the identification of the Huntington disease mutation.     

The role of observer attitudes in judgments of blame in cases of wife assault

This study examines the importance of observer characteristics in determining blame in cases of wife assault. Four independent variables (observer's attitudes toward sex roles, observer sex and age, and victim behavior) were assessed for their influence on the blaming judgments of 128 participants. Subjects completed a questionnaire that contained demographic items and six wife assault vignettes that varied in level of victim provocation (low or high). Questions about blame of the husband and wife followed each vignette. An attitudes toward women scale (AWS-B) was then administered. The main hypothesis, that subjects with traditional attitudes would blame the victim more and the perpetrator less for the assault than their egalitarian counterparts, was supported, as was the prediction of an interaction between provocation and AWS-B. The results are discussed in light of the role of observer attitudes in attribution models.     

Punished and Nonpunished Responding in A Multiple Schedule in Humans: A Brief Report

Four male subjects responded on a multiple schedule in which responding was maintained by a random interval 20-sec (RI20) schedule of point presentation. Responding was suppressed in alternating components by an added variable ratio 30 (VR30) schedule of point subtractions. Each component was accompanied by distinctive stimulus lights. Subjects were exposed to the multiple schedule from the initial session. Two subjects experienced four 50-min sessions daily (Experiment 1) and the other two subjects participated in one 50-min session daily (Experiment 2). Once responding in the punished components had stabilized, responding in the nonpunished components continued to increase across sessions. Nonpunished responding did not stabilize even after as many as 36 sessions. These results are discussed in the context of previous studies using animals which employed multiple schedules with punished and nonpunished response contingencies.

     

An MMPI-based empirical model of malingering and deception

The empirically-based model of malingering and deception described by Rogers (1984b) was operationalized using MMPI and clinical interview data. Subjects (N = 159) were patients committed to an inpatient forensic hospital as ‘Incompetent to Stand Trial’ or ‘Not Guilty by Reason of Insanity’. Inter-rater reliability was acceptable for the 11 criteria used to define response styles. Each subject was categorized into one of five response style groups: ‘Reliable’, ‘Malingering’, ‘Defensive’, ‘Irrelevant’, or ‘Unclassifiable’. Factor analysis of the rating criteria yielded four factors, three of which are comparable to the assigned groups, providing some validation for the constructs underlying these groups.     

Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Contextualizing social identity in considerations of what it means to be a nurse

This paper describes research which provide the context for a discussion of how social representations can circumscribe identity possibilities and render feasible certain groups evaluations. Specifically, a research approach is advocated in which Social Identity and Social Representation Theory are integrated within single complementary paradigm, (Breakwell, 1993). A brief but critical examination of both theoretical traditions is ofered as the backdrop to this. A case study is described as a means of illustrating the unique potential of the integrated paradigm to predict and explain the meaning of social identity and the evaluations it affords. An investigation is then described involving 178 nurses ranging from Trainee to Charge Nurse status. Nurses were invited to use Q-sorts to describe the meaning of their group membership. As predicted from having identified the types of social representation of nurses available, two diferent identity orientations emerged: a communal-interpersonal (Patient Centred) and instrumental-intergroup (Professional Distinctiveness). The communal-interpersonal identity orientation was most typical of the lower status trainee nurses and also female nurses. In turn, higher status nurses and also male nurses, articulated a primarily instrumental-intergroup identity orientation. The evaluations signalled by group membership were also predictable from the identity orientations exhibited.