The twinship: A paradigm towards separation and integration

The twinship paradigm describes a pattern of dyadic, quasi-object relationship, the purpose of which is to facilitate differentiation, separation, and integration. Twinships can arise at any point in the life cycle, when the self faces a developmental impasse. The twin functions as an alter-ego. Twin selection is based on two principles, namely, sympathetic resonance of experience, and difference. The two essentials of the resonance are similarity of developmental task, and similarity of obstacles to its accomplishment. The essentials of the difference lie in the fact that the twin is seen either as an idealized alter-ego, or as the carrier of the self's intolerable aspects. Twinships can collapse, in the presence of massive investment in the archaic symbiotic bond. They then lose their transitional status, and can degenerate into a fixation on a separation-impeding dyadic mode of relating.     

Depolarization-initiated endogenous cannabinoid release and underlying retrograde neurotransmission in interneurons of amygdala

The depolarization is also important for the short-term synaptic plasticity, known as depolarization-induced suppression of excitation (DSE). The two major types of neurons and their synapses in the lateral nucleus of amygdala (LA) are prone to plasticity. However, DSE in interneurons has not been reported in amygdala in general and in LA in particular. Therefore, we conducted the patch-clamp experiments with LA interneurons. These neurons were identified by lack of adaptation in firing rate of action potentials. In this study, we show for the first time a transient suppression of neurotransmission at synapses both within the local network and between cortical inputs and interneurons of the LA. The retrograde neurotransmission from GABAergic interneurons were comparable with that of glutamatergic pyramidal cells. That is the axonal terminals of cortical inputs do not posses selectivity toward two neuronal subtypes. However, the DSE of both types of neurons involve an increase in intracellular Ca²⁺ and the release of endogenous cannabinoids (eCB) and activation of presynaptic CB1 receptors. The magnitude of DSE was significantly higher in interneurons compared with pyramidal cells, though developed with some latency.

…I made experiments on myself and my assistant, using smaller doses, and not repeating them so often… — Clouston 1870

The biological actions of endogenous cannabinoids (eCB) occur by binding to the CB₁ and CB₂ receptors throughout the whole body (Ameri 1999; Pertwee 2006; Hill et al. 2007; Yoshida et al. 2011). The density of CB₁ receptors in the amygdala is comparably high in mammals (Herkenham et al. 1990).Amygdala similar to hippocampus is important for memory formation and often studied to elucidate plasticity at cellular level using the classical paradigm of Pavlov that continuously serves as a substrate (Pavlov 1927; Bliss and Lomo 1973; Rogan et al. 1997). The amygdala not only receives, but also sends behavior underlying signals into other regions (Racine et al. 1983; Aggleton and Mishkin 1984). While the role of hippocampus is crucial for memory formation, those associated with many different kinds of emotions are mainly modulated by the amygdala (Bucherelli et al. 2006; Fujii et al. 2020). The memory enabling substrate is a long-term potentiation (LTP) of neurotransmission into the postsynaptic neurons (Rogan et al. 1997; Kodirov et al. 2006).The short-term synaptic plasticity in the form of depolarization-induced suppression of either excitation or inhibition (DSE and DSI) has been reported in several regions of the brain (Alger et al. 1996; Kano et al. 2009; Ivanova and Storozhuk 2011). We have discovered DSE in the lateral amygdala (LA), specifically at cortical inputs into the pyramidal neurons (Kodirov et al. 2010).Despite the extensive studies on DSE and DSI, there are only three papers on interneurons that we are aware of. Two of them describe the presence of these phenomena: One study was carried out on parvalbumin immunoreactive interneurons of the stratum radiatum in the hippocampus (Ali 2007) and another on cerebellar stellate and basket cells (Beierlein and Regehr 2006). However, none of the cortical interneurons exhibited DSI despite the presence of a functional and cannabinoid-sensitive inhibitory inputs (Lemtiri-Chlieh and Levine 2007). The retrograde neurotransmission (Llano et al. 1991) takes place via the release of two natural ligands of endogenous cannabinoids anandamide and 2-arachidonoyl-glycerol (Urbanski et al. 2009). These ligands also suppress the evoked excitatory neurotransmission when applied exogenously in vitro (Ameri et al. 1999; Ameri and Simmet 2000; Lemak et al. 2007).Since DSE in interneurons has not been reported in amygdala and we demonstrated the existence of DSE in pyramidal cells of LA (Kodirov et al. 2010), we then studied the same phenomenon in regard to interneurons; the main question was whether or not does depolarization-induced mobilization of eCBs from the two types of postsynaptic LA neurons cause similar retrograde modulation of cortical inputs? Subsequently, DSE between the presynaptic terminals and interneurons was shown, and we found that its properties are similar to those in pyramidal cells of LA. Our study documents the participation of endogenous cannabinoids of interneurons in DSE.     

Adolescent boys’ physical fighting and adult life outcomes: Examining the interplay with intelligence

Although it is well known that adolescent delinquent behavior is related to poor outcomes in adulthood, longitudinal research on specific acts of delinquency and their interplay with important individual characteristics in predicting future outcomes is scarce. We aimed to examine how physical fighting—one of the most common acts of violent delinquency among adolescent boys—is related to adult life success in several domains, and how intelligence influences these associations. The study used data from 1,083 boys that participated in the population-based longitudinal Young in Norway Study, following adolescents from 1992 to 2015, by combining self-reports at four time points with comprehensive information from registers. Results showed that adolescent boys’ physical fighting was associated with poor adult outcomes in the domains of employment, education, and criminal behavior. Associations remained significant even after controlling for conduct problems in general—which isolated the effects of fighting from other delinquent acts—as well as from a variety of other potential confounders. Detailed analyses on the interplay of physical fighting and intelligence showed that some parts of the associations between adolescent boys’ fighting and several adverse adult outcomes could be ascribed to lower intelligence among the fighters. Moreover, intelligence moderated the relationship between physical fighting and adult education. Adolescent fighting was not related to educational attainment among boys with high intelligence, whereas boys with lower intelligence experienced detrimental effects of adolescent fighting. The analyses show the importance of considering adolescent boys’ physical fighting as a potential risk factor for future social marginalization.     

Das Antilogische

Ohne Zusammenfassung     

Beobachtungen über ein- und zweiohriges Hören

Ohne Zusammenfassung     

Can public virtues be global?

ABSTRACT

An important issue within the field of global ethics is the extent or scope of moral obligation or duties. Cosmopolitanism argues that we have duties to all human beings by virtue of some common property. Communitarian ethics argue that one's scope of obligation is circumscribed by one's community or some other defining property. Public virtues, understood to be either a property that communities possess to function well or a moral excellence constitutive of that community, offer an interesting challenge to this binary by positing moral goods or excellences that are constitutive of a community yet global in application. Virtues such as tolerance, charity, moderation, or benevolence might be examples of such goods or excellences endorsed by a community but applied to individuals who are not members of the community, or, as in the case of environmental ethics, even to entities that are not moral agents. Unlike cosmopolitan ethics, the scope of the obligation does not depend on identifying universal properties, such as rationality, human dignity, or utility, but could be defined entirely by and within a community.