The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Systematic Review and Meta-analysis

Neuropsychology Review - Mindfulness-based programs (MBPs) are increasingly utilized to improve mental health. Interest in the putative effects of MBPs on cognitive function is also growing. This...     

A strong parietal hub in the small-world network of coloured-hearing synaesthetes during resting state EEG

We investigated whether functional brain networks are different in coloured-hearing synaesthetes compared with non-synaesthetes. Based on resting state electroencephalographic (EEG) activity, graph-theoretical analysis was applied to functional connectivity data obtained from different frequency bands (theta, alpha1, alpha2, and beta) of 12 coloured-hearing synaesthetes and 13 non-synaesthetes. The analysis of functional connectivity was based on estimated intra-cerebral sources of brain activation using standardized low-resolution electrical tomography. These intra-cerebral sources of brain activity were subjected to graph-theoretical analysis yielding measures representing small-world network characteristics (cluster coefficients and path length). In addition, brain regions with strong interconnections were identified (so-called hubs), and the interconnectedness of these hubs were quantified using degree as a measure of connectedness. Our analysis was guided by the two-stage model proposed by Hubbard and Ramachandran (2005). In this model, the parietal lobe is thought to play a pivotal role in binding together the synaesthetic perceptions (hyperbinding). In addition, we hypothesized that the auditory cortex and the fusiform gyrus would qualify as strong hubs in synaesthetes. Although synaesthetes and non-synaesthetes demonstrated a similar small-world network topology, the parietal lobe turned out to be a stronger hub in synaesthetes than in non-synaesthetes supporting the two-stage model. The auditory cortex was also identified as a strong hub in these coloured-hearing synaesthetes (for the alpha2 band). Thus, our a priori hypotheses receive strong support. Several additional hubs (for which no a priori hypothesis has been formulated) were found to be different in terms of the degree measure in synaesthetes, with synaesthetes demonstrating stronger degree measures indicating stronger interconnectedness. These hubs were found in brain areas known to be involved in controlling memory processes (alpha1: hippocampus and retrosplenial area), executive functions (alpha1 and alpha2: ventrolateral prefrontal cortex; theta: inferior frontal cortex), and the generation of perceptions (theta: extrastriate cortex; beta: subcentral area). Taken together this graph-theoretical analysis of the resting state EEG supports the two-stage model in demonstrating that the left-sided parietal lobe is a strong hub region, which is stronger functionally interconnected in synaesthetes than in non-synaesthetes. The right-sided auditory cortex is also a strong hub supporting the idea that coloured-hearing synaesthetes demonstrate a specific auditory cortex. A further important point is that these hub regions are even differently operating at rest supporting the idea that these hub characteristics are predetermining factors of coloured-hearing synaesthesia.     

Multi- and unisensory decoding of words and nonwords result in differential brain responses in dyslexic and nondyslexic adults

The present functional magnetic resonance imaging (fMRI) study was designed, in order to investigate the neural substrates involved in the audiovisual processing of disyllabic German words and pseudowords. Twelve dyslexic and 13 nondyslexic adults performed a lexical decision task while stimuli were presented unimodally (either aurally or visually) or bimodally (audiovisually simultaneously).The behavioral data collected during the experiment evidenced more accurate processing for bimodally than for unimodally presented stimuli irrespective of group. Words were processed faster than pseudowords. Notably, no group differences have been found for either accuracy or for reaction times. With respect to brain responses, nondyslexic compared to dyslexic adults elicited stronger hemodynamic responses in the leftward supramarginal gyrus (SMG), as well as in the right hemispheric superior temporal sulcus (STS). Furthermore, dyslexic compared to nondyslexic adults showed reduced responses to only aurally presented signals and enhanced hemodynamic responses to audiovisual, as well as visual stimulation in the right anterior insula.Our behavioral results evidence that the two groups easily identified the two-syllabic proper nouns that we provided them with. Our fMRI results indicate that dyslexics show less neuronal involvement of heteromodal and extrasylvian regions, namely, the STS, SMG, and insula when decoding phonological information. We posit that dyslexic adults evidence deficient functioning of word processing, which could possibly be attributed to deficits in phoneme to grapheme mapping. This problem may be caused by impaired audiovisual processing in multimodal areas.     

Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo

The cannabinoid receptor type 1 (CB1) is abundantly expressed in the central nervous system where it negatively controls the release of several neurotransmitters. CB1 activity plays a crucial role in learning and memory and in synaptic plasticity. In the present study, the role of CB1 was investigated in three different hippocampus-dependent memory tasks and in in vivo hippocampal synaptic plasticity in knockout (CB1-ko) and wildtype mice. There was no difference in short-term and long-term social and object recognition memory between CB1-ko and wildtype mice. In contrast, in background contextual fear conditioning CB1-ko mice showed enhanced freezing levels in the conditioning context and increased generalised contextual fear after a high-intensity conditioning foot shock of 1.5 mA, but not after 0.7 mA. In in vivo field potential recordings in the dentate gyrus, CB1-ko mice displayed a decreased paired-pulse facilitation of the populations spikes, suggesting an altered inhibitory synaptic drive onto hippocampal granule cells. Furthermore, CB1-ko mice displayed significantly higher levels of in vivo long-term potentiation (LTP) in the dentate gyrus. In conclusion, CB1 deficiency leads to enhanced contextual fear memory and altered synaptic plasticity in the hippocampus, supporting the key role of endocannabinoid signalling in learning and memory, in particular following highly aversive encounters.     

Acoustic Interference in a Recognition Task

Phonetic or acoustic characteristics of stimuli in recall studies have consistently been shown to generate more interference over short intervals than semantic characteristics. We performed three experiments to determine whether this characteristic also applied to recognition processes over short intervals. Subjects were shown study lists of eight words and were asked to recognize which of those words recurred on subsequent eight-word lists. Delays varied from 0 to 100 s between study and test, with a rehearsal-preventing task inserted during the delays. Phonetic distractors generated greater interference than semantic distractors at all delay levels, and semantic distractors generated greater interference than random distractors. These distractor-type differences were not present in long-term recognition tasks. The deterioration in performance over time was considerably slower in these recognition experiments than in previous recall studies.     

Broadening (and narrowing) the scope of brand relationships

The Attachment–Aversion Relationship Model proposed by Park, Eisingerich, and Park represents the latest in a series of attempts to expand, refine, and validate the increasingly popular concept of brand relationships. We find much value in the effort. We suggest, however, that researchers should avoid indiscriminate use of the term and focus on identifying the unique contribution that the notion of brand relationships can make to theory and practice. We also note how the present model could be expanded to achieve this objective.     

Effects of working memory training in young and old adults

Many cognitive abilities, including working memory and reasoning ability, decline with progressing age. In this study, we investigated whether four weeks of intensive working memory training would enhance working memory and reasoning performance in an age-comparative setting. Groups of 34 young (19–36 years) and 27 older (62–77 years) adults practiced tasks representing the three functional categories in the facet model of working memory capacity: storage and processing, relational integration, and supervision. The data were compared to those of a young and an old active control group who practiced tasks with low working memory demands. A cognitive test battery measuring near and far transfer was administered before and after training. Both age groups showed increased working memory performance in the trained tasks and in one structurally similar, but nontrained, task. Young adults also improved in a task measuring word-position binding in working memory. However, we found no far transfer to reasoning in either age group. The results provide evidence that working memory performance can be improved throughout the life span. However, in contrast to a previous study in which each facet of working memory capacity was trained separately, the present study showed that training multiple functional categories simultaneously induces less transfer.     

An Examination of the Value of the Generation Effect for Learning New Material

The generation effect involves an improvement in memory when learners must complete or modify materials. Several researchers have suggested that this effect involves enhanced access to learners' existing memory representations; therefore, the effect should be less effective with meaningless, low meaningful, or unfamiliar material. In the present study, the authors conducted 4 experiments in which legal nonwords were used, and they found no generation effect. In another 2 experiments in which familiar clichés were contrasted with new sentences and with unfamiliar sentences from textbooks, the results showed a greatly reduced generation effect for the new, unfamiliar material. Those findings suggest that memory strategies that depend on the generation effect will have limited effectiveness when they are applied to new or unfamiliar material.     

Number bias for the discrimination of large visual sets in infancy

This brief report attempts to resolve the claim that infants preferentially attend to continuous variables over number [e.g. Psychol. Sci. 10 (1999) 408; Cognit. Psychol.44 (2002) 33] with the finding that when continuous variables are controlled, infants as young as 6-months of age discriminate large numerical values [e.g. Psychol. Sci. 14 (2003) 396; Cognition 89 (2003) B15; Cognition 74 (2000) B1]. In two parallel experiments, we compare 6-month-old infants' ability to discriminate number and ignore continuous variables with their ability to form a representation of a cumulative surface area and ignore number. We find that infants discriminate a 2-fold change in number but fail to discriminate a 2-fold change in cumulative surface area. The results point to a more complicated relationship between discrete and continuous dimensions than implied by previous literature.     

Typical dreams: stability and gender differences

Although the variability of dream content is large, typical dream themes that occur quite often and are reported by many people can be identified (e.g., being chased, falling, flying, failing an examination, being unable to find a toilet or restroom). The present study is an investigation of the stability of the rank order of the dream themes and of gender differences in the content of dreams. The authors administered A. L. Zadra and T. A. Nielsen's (1997) Typical Dream Questionnaire to 444 participants. The findings indicated that most of the 55 dream themes occurred at least once in most of the participants' lifetimes. In addition, the correlation coefficients for the rank order of the themes were very high; that is, the relative frequencies were stable. The gender differences in the present study were in line with content analytic findings; for example, men reported dreams about physical aggression more often than did women. Overall, previous research and the present data indicate that available research results of the measurement of typical dream themes are reliable and valid. The question of the meaning of these themes or the relationship between typical dream contents and waking life experiences, however, has not yet been answered and is open to future research.