Improved low-cost,MR-compatible olfactometer to deliver tobacco smoke odor

We describe a low-cost, MRI-compatible olfactometer that delivers fresh cigarette smoke odor, a challenging odorant to present, as well as other odorants. This new olfactometer retains all of the advantages of an earlier design that was capable of only delivering volatile odors (Lowen & Lukas, Behavior Research Methods, 38, 307–313, 2006). The new system incorporates a novel switching mechanism that allows it to deliver fresh smoke generated from a burning cigarette during a stimulus presentation paradigm that might be employed in a cue-reactivity experiment. An evaluation study established that the olfactometer reliably delivered smoke to the participants and that tobacco smoke was discriminated from other odorants; there were no adverse reactions to the device.     

Illusory own body perceptions: Case reports and relevance for bodily self-consciousness

Neurological disorders of body representation have for a long time suggested the importance of multisensory processing of bodily signals for self-consciousness. One such group of disorders – illusory own body perceptions affecting the entire body – has been proposed to be especially relevant in this respect, based on neurological data as well as philosophical considerations. This has recently been tested experimentally in healthy subjects showing that integration of multisensory bodily signals from the entire body with respect to the three aspects: self-location, first-person perspective, and self-location, is crucial for bodily self-consciousness. Here we present clinical and neuroanatomical data of two neurological patients with paroxysmal disorders of full body representation in whom only one of these aspects, self-identification, was abnormal. We distinguish such disorders of global body representation from related but distinct disorders and discuss their relevance for the neurobiology of bodily self-consciousness.     

Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats

In women, medroxyprogesterone acetate (MPA) is the most commonly used progestin component of hormone therapy (HT). In vitro, MPA negatively impacts markers of neuronal health and exacerbates experimentally-induced neurotoxicity. There is in vitro evidence that these factors are driven by GABAergic and neurotrophic systems. Whether these effects translate to a negative impact on brain function has not been tested in vivo, clinically or preclinically. Here we evaluate the mnemonic and neurobiological effects of MPA in the surgically menopausal rat. Aged ovariectomized (OVX) rats were given subcutaneous vehicle, natural progesterone, low-dose MPA or high-dose MPA. Multiple cognitive domains were analyzed via the water radial-arm maze (WRAM) and Morris maze (MM). Cognitive brain regions were assayed for changes in the GABAergic system by evaluating GAD protein, the synthesizing enzyme for GABA, and neurotrophins. On the WRAM, both progestin types impaired learning. Further, high-dose MPA impaired delayed memory retention on the WRAM, and exacerbated overnight forgetting on the MM. While neurotrophins were not affected by progesterone or MPA treatment, both progestin types altered GAD levels. MPA significantly and progesterone marginally decreased GAD levels in the hippocampus, and both MPA and progesterone significantly increased GAD levels in the entorhinal cortex. These findings suggest that MPA, the most commonly used progestin in HT, is detrimental to learning and two types of memory, and modulates the GABAergic system in cognitive brain regions, in aged surgically menopausal rats. These findings, combined with in vitro evidence that MPA is detrimental to neuronal health, indicates that MPA has negative effects for brain health and function.     

Haptic shape perception from force and position signals varies with exploratory movement direction and the exploring finger

We investigated how exploratory movement influences signal integration in active touch. Participants judged the amplitude of a bump specified by redundant signals: When a finger slides across a bump, the finger’s position follows the bump’s geometry (position signal); simultaneously, it is exposed to patterns of forces depending on the gradient of the bump (force signal). We varied amplitudes specified by force signals independently of amplitudes specified by position signals. Amplitude judgment was a weighted linear function of the amplitudes specified by both signals, under different exploratory conditions. The force signal’s contribution to the judgment was higher when the participants explored with the index finger, as opposed to the thumb, and when they explored along a tangential axis, as opposed to a radial one (pivot ≌ shoulder joint). Furthermore, for tangential, as compared with radial, axis exploration, amplitude judgments were larger (and more accurate), and amplitude discrimination was better. We attribute these exploration-induced differences to biases in estimating bump amplitude from force signals. Given the choice, the participants preferred tangential explorations with the index finger—a behavior that resulted in good discrimination performance. A role for an active explorer, as well as biases that depend on exploration, should be taken into account when signal integration models are extended to active touch.     

Psychometric properties of scales in the General Nordic Questionnaire for Psychological and Social Factors at Work (QPSNordic): Confirmatory factor analysis and prediction of certified long-term sickness absence

Psychometric properties, particularly predictive validity, of scales in the General Nordic Questionnaire for Psychological and Social Factors at Work (QPS_Nordic) were assessed. The analysis is confined to the scales in the QPS_Nordic, and 24 of the 26 scales are included. A large group of Swedish county council employees ( n = 3,976; response rate = 65%) participated in a study and were given the QPS_Nordic. Register data for long-term sick leave (>90 days), with diagnosis, were used for predictive analysis. The following main results were obtained: Reliability was generally satisfactory, confirmatory factor analysis indicated good fit, concurrent validity was good, some less often investigated organizational variables predicted sickness absence, and scales were differentially associated with absence due to psychiatric and musculoskeletal disorders. In conclusion, the psychometric testing of the QPS_Nordic so far suggests that it is a good instrument for assessing health-related factors at work.     

中国背景下员工沉默的测量以及信任对其的影响

应用自行编制的员工沉默行为调查问卷,通过对928名被试的调查,对中国背景下员工沉默行为的结构维度进行了探讨。探索性因素分析结果表明,员工沉默由三个因素构成。三因素结构的结果在验证性因素分析中得到了证实。由此得到结论,员工沉默有三维结构：默许沉默、漠视沉默和防御沉默。以员工沉默的三个维度为因变量,以员工对上级和组织的信任为自变量进行回归分析,结果表明,员工对上级信任对员工沉默三个维度都有负面影响,而员工对组织信任对默许沉默和漠视沉默有负向影响,对防御沉默的影响并不显著     

Modellierung von Fehlkonzepten in einer algebraischen Wissensstruktur

An extension of the theory of knowledge spaces by Doignon &; Falmagne (1985) is presented that tries to account for subjects’ typical errors and wrong answers. This extension concerns two major points: The usual dichotomous item format (right/wrong) is generalized to polytomous response categories, and the theoretical structure (knowledge, skills, misconceptions) is clearly separated from the empirical structure (observable solution behavior, subject’s responses). Using examples from a set of questions about properties of simple electric circuits the general method is demonstrated. Axioms of an algebraic structure known as “information system” (Scott, 1982) are shown to provide an appropriate characterization of the theoretical domain. The structural properties of the data, on the other hand, can be derived from assumptions about the influence of knowledge and misconceptions on specific answers for a set of questions.     

Reading and spelling skills in the first school years predicted from phonemic awareness skills in kindergarten

A series of metalinguistic tasks, including segmentation and synthesis of words, were given to 143 children in kindergarten. The children were followed up in school where reading and writing achievement was assessed with several tests and ratings. A causal model was postulated concering the relationships between general abilities, metalinguistic competence, and reading and spelling skills. The quantitative implications of the model were worked out by path analysis, which revealed an orderly and interpretable picture. The most invariant and important determinant of basic reading and spelling skills was the analysis of simple words. Failure and success in school could be predicted with high accuracy on the basis of preschool data. Over 70% of the children were classified correctly in the extreme quartiles as to their future school achievement. The methodological advantage of applying path analysis instead of conventional multiple regression analysis on the present problem was discussed.     

人际交往能力与生命意义的关系:孤独感和年级的作用

基于存在主义心理学理论,本研究采用人际交往能力问卷、孤独感量表和生命意义量表对福建省三所大学的1476名大一和大二学生进行调查,考察人际交往能力与生命意义的关系,以及孤独感的中介作用和年级的调节作用。结果表明：（1）交往能力和孤独感存在显著的性别差异。男生的交往能力显著高于女生,孤独感显著低于女生;（2）交往能力与孤独感呈显著负相关,与拥有意义和追寻意义均呈显著正相关,而孤独感与它们均呈显著负相关;（3）孤独感在交往能力与拥有生命意义之间的中介作用受到年级的调节。与大二学生相比,大一新生孤独感的中介效应更大。研究结果在一定程度上揭示了交往能力对生命意义的作用过程,为针对性提升大学新生生命意义提供方向指导和实证依据。