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901.
Milena Paneque Carolina Lemos Alda Sousa Luis Velázquez Manuela Fleming Jorge Sequeiros 《Journal of genetic counseling》2009,18(5):483-493
To identify possible factors affecting the psychological impact of pre-symptomatic testing for spinocerebellar ataxia type
2 (SCA2) and familial amyloid polyneuropathy (FAP ATTRV30M), we studied (1) the effect of previous experience with the disease
in the family, (2) kinship with the closest affected relative and (3) gender of affected parent, when adapting to test results;
as well as (4) differences in the course of psychological wellbeing in 63 subjects ( 28 at-risk for FAP ATTRV30M, and 35 at
risk for SCA2), who pursued predictive testing for these diseases, in Cuba and in Portugal. Our research shows that individuals
with little or no experience with the disease in their family exhibited more anxiety; at-risk subjects for SCA2 or FAP ATTRV30M
who had a first degree relative with the disease showed lower levels of anxiety and depression during pre-symptomatic testing.
Also those with an affected mother had lower levels of depression, either immediately, or one year after receipt of test results.
Adaptation to pre-symptomatic testing results differed for subjects at-risk for the two different conditions. Unlike the FAP
ATTRV30M families, carriers for SCA2 reported pathological levels of depression immediately after-testing (3 weeks), although
those levels had returned to normal levels at 6 months. Subjects at-risk for FAP ATTRV30M tended to have less anxiety than
those tested for SCA2, at the one-year follow-up. Overall, depression levels improved over time, while anxiety remained more
constant. A longer awareness of the disease in the family, closer kinship, and a transmitting mother all lessened the impact
of pre-symptomatic testing, as expressed by the post-test levels of anxiety and depression. 相似文献
902.
Laurie Beth Feldman Patrick A. O’Connor Fermín Moscoso del Prado Martín 《Psychonomic bulletin & review》2009,16(4):684-691
Many studies have suggested that a word’s orthographic form must be processed before its meaning becomes available. Some interpret
the (null) finding of equal facilitation after semantically transparent and opaque morphologically related primes in early
stages of morphological processing as consistent with this view. Recent literature suggests that morphological facilitation
tends to be greater after transparent than after opaque primes, however. To determine whether the degree of semantic transparency
influences parsing into a stem and a suffix (morphological decomposition) in the forward masked priming variant of the lexical
decision paradigm, we compared patterns of facilitation between semantically transparent (e.g., coolant—cool) and opaque (e.g., rampant—ramp) prime—target pairs. Form properties of the stem (frequency, neighborhood size, and prime—target letter overlap), as well
as related—unrelated and transparent—opaque affixes, were matched. Morphological facilitation was significantly greater for
semantically transparent pairs than for opaque pairs. Ratings of prime—target relatedness predicted the magnitude of facilitation.
The results limit the scope of form-then-meaning models of word recognition and demonstrate that semantic similarity can influence
even early stages of morphological processing. The research reported here was supported by National Institute of Child Health
and Development Grant HD-01994 to Haskins Laboratories. 相似文献
903.
Daniel Tomsic Martín Bern de Astrada Julieta Sztarker Hector Maldonado 《Neurobiology of learning and memory》2009,92(2):176
Investigations using invertebrate species have led to a considerable progress in our understanding of the mechanisms underlying learning and memory. In this review we describe the main behavioral and neuronal findings obtained by studying the habituation of the escape response to a visual danger stimulus in the crab Chasmagnathus granulatus. Massed training with brief intertrial intervals lead to a rapid reduction of the escape response that recovers after a short term. Conversely, few trials of spaced training renders a slower escape reduction that endures for many days. As predicted by Wagner’s associative theory of habituation, long-term habituation in the crab proved to be determined by an association between the contextual environment of the training and the unconditioned stimulus. By performing intracellular recordings in the brain of the intact animal at the same time it was learning, we identified a group of neurons that remarkably reflects the short- and long-term behavioral changes. Thus, the visual memory abilities of crabs, their relatively simple and accessible nervous system, and the recording stability that can be achieved with their neurons provide an opportunity for uncovering neurophysiological and molecular events that occur in identifiable neurons during learning. 相似文献
904.
Traditionally, liberals have confined religion to the sphere of the ‘private’ or ‘non-political’. However, recent debates
over the place of religious symbols in public spaces, state financing of faith schools, and tax relief for religious organisations
suggest that this distinction is not particularly useful in easing the tension between liberal commitments to equality on
the one hand, and freedom of religion on the other. This article deals with one aspect of this debate, which concerns whether
members of religious communities should receive exemptions from regulations that place a distinctively heavy burden on them.
Drawing on Habermas’ understanding of churches as ‘communities of interpretation’, we explore possible alternatives to both
the ‘rule-and-exemption’ approach and the ‘neutralist’ approach. Our proposal rests on the idea of mutual learning between
secular and religious perspectives. On this interpretation, what is required is (i) the generation and maintenance of public
spaces in which there could be discussion and dialogue about particular cases, and (ii) evaluation of whether the basic conditions
of moral discourse are present in these spaces. Thus deliberation becomes a touchstone for the building of a shared democratic
ethos. 相似文献
905.
Maturational changes in the capacity to process quickly the temporal envelope of sound have been linked to language abilities in typically developing individuals. As part of a longitudinal study of brain maturation and cognitive development during adolescence, we employed dense‐array EEG and spatiotemporal source analysis to characterize maturational changes in the timing of brain responses to temporal variations in sound. We found significant changes in the brain responses compared longitudinally at two time points in early adolescence, namely 10 years (65 subjects) and 11.5 years (60 of the 65 subjects), as well as large differences between adults, studied with the same protocol ( Poulsen, Picton & Paus, 2007 ), and the children at 10 and 11.5 years of age. The transient auditory evoked potential to tone onset showed decreases in the latency of vertex and T‐complex components, and a highly significant increase in the amplitude of the N1 wave with increasing age. The auditory steady state response to a 40‐Hz frequency‐modulated tone increased in amplitude with increasing age. The peak frequency of the envelope‐following response to sweeps of amplitude‐modulated white noise also increased significantly with increasing age. These results indicate persistent maturation of the cortical mechanisms for auditory processing from childhood into middle adulthood. 相似文献
906.
Ágnes Melinda Kovács 《Developmental science》2009,12(1):48-54
In their first years, children's understanding of mental states seems to improve dramatically, but the mechanisms underlying these changes are still unclear. Such ‘theory of mind’ (ToM) abilities may arise during development, or have an innate basis, developmental changes reflecting limitations of other abilities involved in ToM tasks (e.g. inhibition). Special circumstances such as early bilingualism may enhance ToM development or other capacities required by ToM tasks. Here we compare 3‐year‐old bilinguals and monolinguals on a standard ToM task, a modified ToM task and a control task involving physical reasoning. The modified ToM task mimicked a language‐switch situation that bilinguals often encounter and that could influence their ToM abilities. If such experience contributes to an early consolidation of ToM in bilinguals, they should be selectively enhanced in the modified task. In contrast, if bilinguals have an advantage due to better executive inhibitory abilities involved in ToM tasks, they should outperform monolinguals on both ToM tasks, inhibitory demands being similar. Bilingual children showed an advantage on the two ToM tasks but not on the control task. The precocious success of bilinguals may be associated with their well‐developed control functions formed during monitoring and selecting languages. 相似文献
907.
Katrin Skoruppa Ferran Pons Anne Christophe Laura Bosch Emmanuel Dupoux Núria Sebastián‐Gallés Rita Alves Limissuri Sharon Peperkamp 《Developmental science》2009,12(6):914-919
During the first year of life, infants begin to have difficulties perceiving non‐native vowel and consonant contrasts, thus adapting their perception to the phonetic categories of the target language. In this paper, we examine the perception of a non‐segmental feature, i.e. stress. Previous research with adults has shown that speakers of French (a language with fixed stress) have great difficulties in perceiving stress contrasts ( Dupoux, Pallier, Sebastián & Mehler, 1997 ), whereas speakers of Spanish (a language with lexically contrastive stress) perceive these contrasts as accurately as segmental contrasts. We show that language‐specific differences in the perception of stress likewise arise during the first year of life. Specifically, 9‐month‐old Spanish infants successfully distinguish between stress‐initial and stress‐final pseudo‐words, while French infants of this age show no sign of discrimination. In a second experiment using multiple tokens of a single pseudo‐word, French infants of the same age successfully discriminate between the two stress patterns, showing that they are able to perceive the acoustic correlates of stress. Their failure to discriminate stress patterns in the first experiment thus reflects an inability to process stress at an abstract, phonological level. 相似文献
908.
909.
This article compiles the investigations carried out by a Research Group of the University of Granada, Spain. Its different
projects on writing’s cognitive social and cultural processes have been supported by the Spanish Government. This line of
research joined together linguistic, psychological, social and cultural contributions to the development of writing from the
1970s. Currently, this line of research develops in collaboration with other European Universities: (a) Interuniversity Centre
for Research On Cognitive Processing in Natural and Artificial Systems (ECONA), “La Sapienza” University of Rome (Italy);
(b) Anadolu University, (Eskisehir, Turkey); (c) Coimbra University (Portugal); (d) University of Zaragoza (Spain); (e) the
Institute of Education of the University of London (United Kingdom). The aforementioned collaboration is materializing into
projects like the International Master on Multilingual Writing: Cognitive, Intercultural and Technological Processes of Written
Communication () and the International Congress: Writing in the twenty-first Century: Cognition, Multilinguisim and Technologies, held in
Granada (). This research line is focussed on the development of strategies in writing development, basic to train twenty-first century
societies’ citizens. In these societies, participation in production media, social exchange and the development of multilingual
written communication skills through new computer technologies spread multicultural values. In order to fulfil the social
exigencies, it is needed to have the collaboration of research groups for designing and applying international research projects.
International Master. Multilingual Writing Web: , . 相似文献
910.
This article presents the Spanish adaptation of the Affective Norms for English Words (ANEW; Bradley & Lang, 1999). The norms are based on 720 participants' assessments of the translation into Spanish of the 1,034 words included in the ANEW. The evaluations were done in the dimensions of valence, arousal and dominance using the Self-Assessment Manikin (SAM). Apart from these dimensions, five objective (number of letters, number of syllables, grammatical class, frequency and number of orthographic neighbors) and three subjective (familiarity, concreteness and imageability) psycholinguistic indexes are included. The Spanish adaptation of ANEW can be downloaded at www.psychonomic.org. 相似文献