Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1c

Homer1 belongs to a family of scaffolding proteins that interact with various post-synaptic density proteins including group I metabotropic glutamate receptors (mGluR1/5). Previous research in our laboratory implicates the Homer1c isoform in spatial learning. Homer1 knockout mice (H1-KO) display cognitive impairments, but their synaptic plasticity properties have not been described. Here, we investigated the role of Homer1 in long-term potentiation (LTP) in the hippocampal CA1 region of H1-KO mice in vitro. We found that late-phase LTP elicited by high frequency stimulation (HFS) was impaired, and that the induction and maintenance of theta burst stimulation (TBS) LTP were reduced in H1-KO. To test the hypothesis that Homer1c was sufficient to rescue these LTP deficits, we delivered Homer1c to the hippocampus of H1-KO using recombinant adeno-associated virus (rAAV). We found that rAAV-Homer1c rescued HFS and TBS-LTP in H1-KO animals. Next, we tested whether the LTP rescue by Homer1c was occurring via mGluR1/5. A selective mGluR5 antagonist, but not an mGluR1 antagonist, blocked the Homer1c-induced recovery of late-LTP, suggesting that Homer1c mediates functional effects on plasticity via mGluR5. To investigate the role of Homer1c in spatial learning, we injected rAAV-Homer1c to the hippocampus of H1-KO. We found that rAAV-Homer1c significantly improved H1-KO performance in the Radial Arm Water Maze. These results point to a significant role for Homer1c in synaptic plasticity and learning.     

Adherence to Hormone Replacement Therapy: A Longitudinal Study Using the Theory of Planned Behaviour

The aim of this longitudinal study was to assess the stability and determinants of the intention to adopt HRT over a one-year period using the Theory of Planned Behaviour. At baseline, a total of 644 middle-aged premenopausal women who had never used HRT, were recruited. At follow-up, 417 women completed an interview to assess any change in their reproductive status and in their behavioural intention. Among women who stayed premenopausal (n = 172) and among those who became perimenopausal (n = 209), the intention to adopt HRT was quite stable over the one-year period. However, being perimenopausal had a significant effect on the intention to adopt HRT at follow-up, as did subjective norm, perceived behavioural control and moral norm measured at baseline. Attitude towards HRT did not have a significant effect on the intention to adopt HRT one year later. Therefore, interventions to support women's decision-making about HRT should be tailored to their menopausal status and take into account their perception of social pressure to perform, control over this behaviour and moral obligation.     

Body height and occupational success for actors and actresses

The association of body height with occupational success has been frequently studied, with previous research mainly finding a positive effect among men and positive or null effects among women. Occupational success has almost exclusively been measured so far by short-term success variables (e.g., annual income). In the present study, the relationship of success and height was examined in a group of actors and actresses using a large online database about movies (Internet Movie Database) where heights of actors and actresses are stated. The number of roles played in movies and television series during each actor's lifetime was used as a measure of long-term occupational success. No height effect was found for male actors but a significant negative effect was found for actresses, even after controlling for possible confounding influences (age and birth year). Compared to the general population, actors and actresses were significantly taller; however, actresses who were shorter than average were more likely to achieve greater occupational success, in terms of being featured in more movies.     

The effectiveness of family-based cognitive-behavior grief therapy to prevent complicated grief in relatives of suicide victims: the mediating role of suicide ideation

Grief interventions are more effective for high risk individuals. The presence of suicide ideation following suicide bereavement was examined to determine whether it indicates a high risk status. Using data from a randomized controlled trial (n = 122) on the effectiveness of cognitive-behavior therapy, the effect of suicide ideation on the effectiveness of grief therapy on the bereavement outcome at 13 months post loss was examined. Results show that suicide ideators more often have a history of mental disorder and suicidal behavior than non-ideators, and suicide ideation indicates a high risk for adverse bereavement outcome. Grief therapy likely reduces the risk of maladaptive grief reactions among suicide ideators. Therefore, suicide ideators may benefit from grief therapy following a loss through suicide.     

“I Love You, and I Cheated”: Investigating Disclosures of Infidelity to Primary Romantic Partners

The research presented in this article used a quantitative–qualitative mixed design to investigate components of infidelity. Two studies were completed. The first study compared responses from persons (n = 22, 16 women, 6 men) who, in the context of a romantic relationship, disclosed infidelity to their primary partner, with a matched control sample of persons (n = 22, 16 women, 6 men) who did not report infidelity. Study 2 involved in-depth, bibliographic interviews with those persons disclosing infidelity to primary partners. Study 2 explored how persons defined infidelity and the nature of their disclosure. As predicted, results from Study 1 demonstrated clear differences between persons who did and did not report infidelity on measures of sexual permissiveness and intentions to engage in extradyadic activity, but not on other sexological measures. In Study 2, disclosures of infidelity to primary partners were interrogated using principles of interpretive biography. Qualitative analyses revealed that disclosures of infidelity were embedded with multiple meanings, including transformative moments of self-understanding. Results from the current research add depth to researchers’ and clinicians’ understanding of how infidelity is defined and disclosed to partners.     

Memories of "Bad" Days Are More Biased Than Memories of "Good" Days: Past Saturdays Vary, but Past Mondays Are Always Blue

In a survey of 202 participants, Monday was cited most frequently as the worst morning (65%) and evening (35%); whereas Friday (43%) and Saturday (45%) were the best evening and morning, respectively. Test–retest reliability was higher for worst morning (.89) and evening (.83) judgments, compared to best morning (.44) and evening (.61) judgments. In a second survey of 353 participants, ratings of typical moods were lowest on Monday, rising to a peak on Saturday, but actual momentary moods showed little or no variation by day. Remembered moods from the previous Monday were more strongly related to typical moods than to actual moods, but the reverse was true of remembered moods from the previous Friday and Saturday.     

Neurocognitive and functional outcomes in persons recovering from West Nile virus illness

Long‐term neurocognitive and functional impairments following West Nile virus (WNV) disease are poorly understood. We assessed quality‐of‐life indices and neurocognitive performance in a cohort of 54 persons recovering from one of three WNV disease syndromes (fever [WNF], meningitis [WNM], or encephalitis [WNE]) approximately 1.5 years following acute illness. We compared findings between the three syndromic groups; the study cohort and a demographically similar group of 55 controls from a study of chronic fatigue syndrome (CFS); and the study cohort and a ‘normative’ control population based on cognitive test data. Persistent symptoms, diminished quality of life, and functional impairment were reported by 50% of WNF patients, and 75% each of WNM and WNE patients. Overall, objective neurocognitive performance did not differ significantly between the three syndromic groups, or between the study cohort and the CFS controls or the normative controls. In some neurocognitive subtests, the study cohort scored below the 15th percentile when compared with normative control data. Most persons who returned to independent living following hospitalization for WNV illness had persistent subjective complaints, but had normal cognitive function. However, a minority displayed subtle neurocognitive deficits more than 18 months following acute disease.     

La pratique répétée du Trail Making Test réduit les différences liées à l’âge sur la performance à ce test

Age-related impairment in executive functioning has been found to explain partially the decrease of cognitive performance with aging. However, the practice of an executive test can improve performance to this test. In the present study, we investigated first how the practice of the Trail Making Test (TMT, flexibility test) may influence the age-related deficit to the performance in this test and then how the performance tended to improve, and at which pace, through the practice of this executive test. Two age groups of participants (young and older adults) practiced the TMT and were compared to two control groups (i.e., no practice between pre- and post-test). The practice groups’ scores were obtained at the end of each session. Globally, the results showed an improvement of performance (1) greater in the practice groups than in the control groups and (2) in practice groups, greater in older adults than in younger ones. Both younger and older adults progressed during the early practice sessions but the younger ones reached their optimal level earlier than the older adults who continued to improve over the sessions. These results could have a major impact on adapting cognitive stimulation programs to individual's characteristics such as age.