Introducing a novel method to assess cumulative steroid concentrations: increased hair cortisol concentrations over 6 months in medicated patients with depression

Depression has been linked to increased cortisol concentrations using point measures taken from urine, blood, or saliva samples. However, with regard to hypercortisolism-induced consequences, long-term cumulative cortisol burden is of relevance. Our objective was to use hair analysis as a new method to assess cortisol exposure over 6 months in depressed patients and healthy controls. We examined 23 depressed patients (8 men and 15 women, mean age: 41.6 years (?±?standard deviation (SD), 13.1 years); mean duration of current depressive episode 9 months (?±?SD, 13 months)) and 64 healthy controls, matched for age and gender. Cortisol concentrations in two 3-cm hair segments from near to the scalp were analyzed, representing cortisol secretion during the 6 months prior to sampling. Compared with healthy individuals, depressed patients had higher hair cortisol concentrations in the first (mean?±?SD: 26.7?±?20.8 vs. 18.7?±?11.5?pg/mg, p?相似文献   

The Effects of Hippocampal and Area Parahippocampalis Lesions in Pigeons: II. Concurrent Discrimination and Spatial Memory

Two experiments were conducted to examine the effects of bilateral hippocampus (Hp) and area parahippocampalis (APH) lesions in pigeons on the acquisition of a visual and spatial task. In Experiment 1, pigeons were trained on three successive six-pair concurrent discrimination tasks, each using a novel set of stimuli. There was no difference between control unoperated pigeons and Hp-APH pigeons in terms of the number of sessions required to learn either the first, second, or third concurrent discrimination task. In Experiment 2, the same pigeons were trained on an open-field spatial task similar in many ways to the radial-arm maze task used with rats. In contrast to the absence of impairments on the visual concurrent discrimination task, pigeons with Hp-APH lesions were severely impaired on the acquisition of the spatial task. These findings support the view that the Hp-APH in pigeons is important for the processing of spatial, rather than visual information.     

FEMINIST CONTRIBUTIONS TO COUNSELING PSYCHOLOGY

In this article we first identify and provide evidence for feminist contributions to counseling psychology in four broad areas. These are policy and leadership in the field, theory and research, training and practice, and recognition of feminist scholarship and contributions by women. In view of the evidence, we conclude that feminist perspectives are irrevocably changing the field of counseling psychology by stimulating the rethinking of its premises and models with regard to normal development and by developing new approaches to inquiry and practice.     

Discrimination learning during the first year: stimulus and positional cues

In four studies, 3-, 6-, and 9-month-old human infants were tested in a discrimination learning task in which visual fixation to a particular stimulus or lateral position was reinforced with an auditory stimulus. In Experiment 1, all age groups exhibited acquisition, extinction, and reinstatement of fixation to the reinforced target or position. Experiment 2 revealed that 3-month-olds retained the positional discrimination but not the stimulus discrimination after a 5-min delay between acquisition and extinction; older infants retained both types of discriminations. In Experiments 3 and 4 we investigated a possible developmental shift in the dominance of positional versus stimulus cues by training infants on displays in which stimulus and position were confounded and then by dissociating the cues on test trials. Results from both experiments indicated positional cue dominance for young infants and stimulus cue dominance for older infants. The findings are discussed in terms of differences in the attentional demands elicited by proprioceptive versus exteroceptive cues.     

Working Lesbians: Role Conflicts and Coping Strategies

This study investigated areas of interrole and intrarole conflict reported by 79 lesbian working women and factors influencing the types of coping strategies these women used. The three coping strategies identified by Hall (1972) were used to code responses to a questionnaire sent to women on the mailing list of a local lesbian newsletter. The most frequently reported interrole conflicts were between the work and lover roles, and the most frequently reported intrarole conflicts involved the work and daughter roles. Subjects viewed being lesbian as contributing little to their interrole conflicts and as hypothesized, used predominantly role restructuring strategies (Types I and II) to deal with the conflicts. Also, as hypothesized, higher self-esteem was reported by individuals using restructuring strategies than by those using reactant strategies (Type III). In contrast, subjects viewed being lesbian as highly related to their intrarole conflicts, and contrary to predictions, used reactive strategies almost as frequently as role restructuring strategies. Moreover, self-esteem did not differ among subjects using the three strategy types. The unexpected findings for intrarole conflict are discussed in terms of the potential benefits of reactant-avoidant strategies in work situations.