Amygdalar Volume in Borderline Personality Disorder With and Without Comorbid Post-traumatic Stress Disorder: A Meta-analysis

IntroductionFour studies have found a smaller amygdalar volume in patients with borderline personality disorder (BPD) relative to controls, whereas four other studies have found similar amygdalar volume in BPD patients relative to controls. This study aims to compare amygdalar volumes of BPD patients with controls, and also to compare BPD patients with and without post-traumatic stress disorder (PTSD) with controls in order to determine whether PTSD can explain the heterogeneity of findings.MethodSystematic review and meta-analysis of magnetic resonance imaging studies that measured amygdalar volumes in BPD patients and healthy controls.FindingsA significant reduction of amygdalar volumes in BPD patients was confirmed (p < .001). However, data from the studies that discriminated BPD patients with and without PTSD indicated that amygdalar volumes were significantly smaller in BPD patients without PTSD relative to controls (left: p = .02; right: p = .05), but not in BPD patients with PTSD relative to controls (left: p = .08; right: p = .20).ConclusionThis meta-analysis suggests that amygdalar volumes are reduced in patients with BPD. This pattern is confirmed in BPD patients without PTSD, but not in BPD patients with PTSD, raising the possibility that reduced amygdalar volume in BPD patients cannot be explained by comorbid PTSD.     

THE BASIS OF SUPERSTITIOUS BEHAVIOR: CHANCE CONTINGENCY,STIMULUS SUBSTITUTION,OR APPETITIVE BEHAVIOR?

This research examined three explanations for the "superstitious" behavior of pigeons under frequent fixed-time delivery of food: accidental response-reward contingency, stimulus substitution, and elicited species-typical appetitive behavior. The behavior observed in these studies consisted of occasional postfood locomotion away from the food hopper, and a predominant pattern of activity directed toward the hopper wall (wall-directed behavior), including approaching, stepping side to side, scratching with the feet, bumping with the breast, pendulum movements of the extended neck, and head bobbing, though not pecking. The consistency of these behavior patterns argued against explanation by accidental response contingencies, and the complexity of behavior was incompatible with the classic stimulus-substitution account. These studies also showed that: (1) response contingencies and prior stimulus experience can modify wall-directed behavior, but within definable limits; (2) pecking sometimes can be obtained in birds of specific strains, and by providing extended training; (3) placing the hopper in the floor at the center of a large chamber replaces wall-directed behavior with circling in a manner that resembles ground foraging for food. We conclude that superstitious behavior under periodic delivery of food probably develops from components of species-typical patterns of appetitive behavior related to feeding. These patterns are elicited by a combination of frequent food presentations and the supporting stimuli present in the environment.     

The effects of unstable clients in adolescent treatment: contagion versus continuity

This study examined the effects of integrating an unstable group of seriously disturbed adolescents into an existing day treatment program. Behavioral data were collected for an established group of subjects who were in treatment one year prior to and one year after the arrival of a new group of severely disturbed adolescents. It was found that the disruptive behavior displayed by the new admission subjects was not imitated by the subjects of the established group. Rather, there was a significant decrease in aggression and in the overall number of psychiatric events for the established group. The treatment milieu was seen to be resistant to the effects of the new admissions largely due to the structured form of treatment.     

The role of the magazine-response contingency on signal-directed responding in pigeons

Three experiments used a procedure for directly delivering water into the thirsty pigeon's mouth to explore the role that the instrumental magazine contingency plays in autoshaped responding. Magazine training was accomplished by requiring birds to contact a “magazine” key when it was illuminated, in order to obtain intraoral injections of water. Other subjects received water injections independent of a magazine-response contingency. Subsequently, magazine-trained subjects showed a transient enhancement in responding to the illumination of another “signal” key, whether that stimulus was presented alone or paired with water delivery. The overall level of maintained autoshaped responding was little influenced by the instrumental magazine contingency, although the within-trial time course of signal-directed responding was affected. When illumination of the signal key preceded access to water only when the signal was not contacted, pigeons directed many responses toward the signal key. However, there was no evidence that the instrumental magazine contingency enhanced responding on this omission schedule of reinforcement. These results thus confirm a small, but measurable contribution of the magazine-response contingency to signal-directed responding; they fail to support the conclusion that the instrumental magazine contingency greatly affects the outcomes of autoshaping studies.     

Trace autoshaping: Acquisition, maintenance, and path dependence at long trace intervals

The pigeon's tendency to acquire and maintain signal-directed key pecking under a trace conditioning procedure was parametrically examined. In Experiment 1, the percentage of CS trials with a key peck response was a decreasing function of the trace interval for separate groups of pigeons. The majority of subjects acquired signal-directed key pecking with trace intervals as long as 36 sec. In Experiment 2, differential maintenance of key pecking occurred across trace intervals in a within-subject procedure. Maintenance of key pecking at 36- and 60-sec trace intervals was path dependent in that responding depended on the subject's performance under the preceding trace interval.     

Negative anticipatory contrast and preference conditioning: flavor cues support preference conditioning, and environmental cues support contrast.

In 2 experiments, access to a 0.15% saccharin solution was followed on alternating days by access to a 32% sucrose solution and the same saccharin solution. In Experiment 1, rats increased both intake of and preference for a flavored saccharin solution that predicted sucrose, but neither effect was found using a predictive odor cue alone. Experiment 2 replicated the predictive flavor results but showed suppression of saccharin intake when environmental cues predicted sucrose. When both flavor and environment predicted sucrose, saccharin intake did not change, but preference for the predictive flavor increased. Discriminative taste cues appear to facilitate the development of preference conditioning, but environmental cues favor negative anticipatory contrast effects. Also, preference conditioning and contrast may develop concurrently and compete for expression.     

Context effects in lexical access: A meta-analysis

The modularity hypothesis was evaluated in this review of 25 studies that investigated context effects in early lexical processing. Selection criteria restricted the review to priming studies and to studies that presented the target word before or at the end of the prime word. Meta-analysis was used to provide summary information about the 17 studies in the review for which effect sizes could be calculated. Overall, the analysis revealed a small effect of context on lexical access. Results provide a disconfirmation of the modularity hypothesis; although multiple interpretations of a word were sometimes accessed, the contextually appropriate interpretation was consistently more strongly activated. The lack of significant heterogeneity of variance suggests that the variability observed across studies was due to sampling error; however, task, timing of target presentation, meaning frequency, type of target, and type of context were identified as potential moderator variables.     

Features of Interview Questions Associated with Attenuation of Symptom Reports

Previous studies have suggested that discrepant reporting in a test–retest reliability paradigm is not purely random measurement error, but partly a function of a systematic tendency to say no during retest to questions answered positively at initial testing (attenuation). To examine features of interview questions that may be associated with attenuation, three raters independently assessed the structural and content features of questions from the Diagnostic Interview Schedule for Children (version 2.3) and linked these to data from a test–retest reliability study of 223 community respondents (parent and child reports). Results indicated that for both parent and youth reports, item features most strongly associated with attenuation were (a) being a stem question (asked of all respondents, regardless of any skip structure); (b) question placement in the first half of the interview; (c) question length; (d) question complexity; or (e) requiring assessment of the timing, duration, or frequency of a symptom. Findings may be explained by participants' conscious efforts to avoid further questions or by their learning more about the nature and purpose of the interview as they gain more experience; alternatively, findings may represent a methodological artifact of structured interview design.