Mid-life stress is associated with both up- and down-regulation of markers of humoral and cellular immunity

Perception of stress with consequent activation of a neuroendocrine cascade causes changes in immune function that may be bi-directional, with alterations in basal levels of biological parameters outside the optimal range. In this cross-sectional study of 302 healthy persons (males 56.3%, females 43.7%) aged 41-46 years, higher stress levels, as assessed by questionnaire measures of recurrent and recent perceived stress, were associated with a 4-fold greater risk of having a high compared to mid-range serum neopterin concentration, indicating activation of cellular immune mechanisms [adjusted odds ratio, OR; (95% confidence intervals, CI): Low stress=1.00 (reference group); Medium stress=4.13 (1.51, 11.29); High stress=4.63, (1.35, 15.83), p for trend=0.01]. Higher stress levels were associated with a 3-fold greater risk of having signs of humoral immune activation, as indicated by salivary IgA concentration [high compared to mid-range salivary IgA: Low stress=1.00 (reference group); Medium stress=1.06 (0.48, 2.34); High stress=3.62 (1.26, 10.39), p for trend=0.02], but also a 4-fold greater risk of humoral immune depression [low compared to mid-range IgA: Low stress=1.00 (reference group); Medium stress=1.72 (0.74, 3.99); High stress=4.38 (1.47, 13.00), p for trend=0.02]. In conclusion, in this cross-sectional study, higher stress levels were associated with higher serum neopterin and both elevated and depressed salivary IgA levels. These findings emphasise the importance of considering that stress may have bi-directional effects on immune mechanisms, and are consistent with an activational effect of chronic, perceived stress on cellular immunity, and a bi-directional effect on IgA levels, one aspect of humoral immunity.     

The Optimum Level of Well-Being: Can People Be Too Happy?

ABSTRACT— Psychologists, self-help gurus, and parents all work to make their clients, friends, and children happier. Recent research indicates that happiness is functional and generally leads to success. However, most people are already above neutral in happiness, which raises the question of whether higher levels of happiness facilitate more effective functioning than do lower levels. Our analyses of large survey data and longitudinal data show that people who experience the highest levels of happiness are the most successful in terms of close relationships and volunteer work, but that those who experience slightly lower levels of happiness are the most successful in terms of income, education, and political participation. Once people are moderately happy, the most effective level of happiness appears to depend on the specific outcomes used to define success, as well as the resources that are available.     

Do Social Relationships Buffer the Effects of Widowhood? A Prospective Study of Adaptation to the Loss of a Spouse

The idea that strong social relationships can buffer the negative effects of stress on well‐being has received much attention in existing literature. However, previous studies have used less than ideal research designs to test this hypothesis, making it difficult to draw firm conclusions regarding the buffering effects of social support. In this study, we examined the buffering hypothesis in the context of reaction and adaptation to widowhood in three large longitudinal datasets. We tested whether social relationships moderated reaction and adaptation to widowhood in samples of people who experienced loss of a spouse from three longitudinal datasets of nationally representative samples from Germany (N = 1,195), Great Britain (N = 562), and Australia (N = 298). We found no evidence that social relationships established before widowhood buffered either reaction or adaptation to the death of one's spouse. Similarly, social relationships that were in place during the first year of widowhood did not help widows and widowers recover from this difficult event. Social relationships acquired prior to widowhood, or those available in early stages of widowhood, do not appear to explain individual differences in adaptation to loss.     

Peer relationships in counseling psychology training

Twelve students from APA-accredited counseling psychology doctoral programs were interviewed about their experiences with peers in their program, and about their values and beliefs about peer relationships in graduate school. Interview data were analyzed using consensual qualitative research. Participants reported a wide range of positive (e.g. collaborative and supportive) and negative (e.g. competitive and hostile) interactions with peers inside and outside of the classroom, in research, and in clinical work. Compared to advisory and supervisory relationships, peer relationships were typically less formal and more open. The sharing of common training experiences generally facilitated mutual understanding among trainees. In addition, a visual analog scale, the peer relationship scale (PRS), was used to measure participants’ closeness with peers. Results from the PRS appeared to be useful in distinguishing participants with the most positive and negative peer relationships, warranting further investigation of its psychometric properties and application in program evaluation and research on training. Implications for training are discussed.     

Evaluation of a Heredofamilial Cancer Unit in Increasing Family History Collection and Genetic Counseling Referrals Among Spanish Oncologists at a University Hospital

A comprehensive family history is essential to identify patients at risk for hereditary cancer who could benefit from genetic counseling (GC). In a previous study, we observed a low occurrence of family history record (FHR) collection rate and GC referral among oncologists at our institution. The present work analyzes whether the implementation of a heredofamilial cancer unit (HFCU) would improve these parameters. We retrospectively compared the FHR rate in clinical records, National Cancer Institute (NCI) general criteria for hereditary cancer suspicion, GC referrals and FHR quality in two cohorts: cohort 1 (patients diagnosed before HFCU creation) and cohort 2 (after HFCU creation). Of 1,175 patients (590 cohort 1 and 585 cohort 2), FHRs were consigned in 27.3 % and 52.5 % of patients, respectively (p?<?0.001). The GC referral of patients with any NCI criterion was 13.6 % xin cohort 1 vs. 40.5 % in cohort 2 (p?<?0.001). FHR quality improved in terms of the total number of relatives (164 vs. 314, p?=?0.1, N.S.) and number of healthy relatives consigned (80 vs. 191, p?<?0.01). Nine mutations (6 BRCA, 1 MEN1, 2 Lynch), 4 unknown significance variants (all in BRCA) and 2 with no mutation were identified among patients referred from cohort 2. We conclude that the creation of a heredofamilial cancer unit has changed both FHR and GC referrals among oncologists at our institution, although continuous educational efforts are required.     

The Logics of Strict-Tolerant Logic

Adding a transparent truth predicate to a language completely governed by classical logic is not possible. The trouble, as is well-known, comes from paradoxes such as the Liar and Curry. Recently, Cobreros, Egré, Ripley and van Rooij have put forward an approach based on a non-transitive notion of consequence which is suitable to deal with semantic paradoxes while having a transparent truth predicate together with classical logic. Nevertheless, there are some interesting issues concerning the set of metainferences validated by this logic. In this paper, we show that this logic, once it is adequately understood, is weaker than classical logic. Moreover, the logic is in a way similar to the paraconsistent logic LP.