Substance P antagonists: meet the new drugs,same as the old drugs? Insights from transgenic animal models

Antidepressants that primarily target the reuptake of monoamines have been highly successful treatments. However, therapies with these drugs still have several drawbacks, namely severe side effects, delays in the onset of action, and a significant percentage of non-responders. Recently, non-peptidic antagonists of the neurokinin 1 receptor, or substance P antagonists, have emerged as a novel class of drugs with antidepressant efficacy that is comparable to current drugs, but a potentially reduced side effect profile. This review summarizes the pre-clinical evidence derived from pharmacological and transgenic animal studies that suggests an important role for the substance P/neurokinin 1 system in anxiety and depression. Also, potential mechanisms by which substance P antagonists may produce their therapeutic effects are discussed.     

Laterality effects in the spinning dancer illusion: The viewing‐from‐above bias is only part of the story

The ‘silhouette illusion’, representing the silhouette of a female dancer pirouetting about her vertical axis, is a bistable stimulus created by Japanese web designer Nobuyuki Kayahara. Although the dancer can be perceived as spinning either clockwise or counterclockwise, the clockwise rotation is usually preferred. Troje and McAdam (i‐Perception, 2010, 1, 143) showed that this clockwise bias can be attributed to the tendency to assume a viewpoint from above rather than from below, given that the dancer is portrayed from a vantage point that is not perpendicular to the axis of rotation. Here, we tested whether another possible factor contributing to the observers’ interpretation of this bistable stimulus might be the tendency to perceive movements of the right rather than the left foot. We confirmed both the viewing‐from‐above bias and our hypothesis. The bias to perceive movements of the right leg might be a generalization to lower limbs of a perceptual frequency effect already observed for upper limbs. Such a perceptual and attentional bias towards the right hand/foot could account for the greater ability to predict the outcome of sport actions when observing right‐ rather than left‐limbed movements, and thus the left‐handers' and left‐footers' advantage observed in a variety of interactive sports.     

Drug Use Among Immigrant and Non‐immigrant Adolescents: Immigrant Paradox,Family and Peer Influences

The present study compared immigrant and Italian native adolescents with regard to drug use. Additionally, we analysed the role of family and peer risk and protective factors for drug use. Participants included 2533 Italian native and immigrant adolescents (mean age = 17.19, SD = 1.6; 66.7% male). Results showed that immigrant adolescents reported lower levels of marijuana and pharmaceutical drug abuse than non‐immigrant adolescents. These results confirm the so‐called immigrant paradox phenomenon: the counterintuitive finding that although immigrants often live under challenging conditions and reported lower economic affluence compared with nationals, some health outcomes have not always corresponded to their relative disadvantage. Immigrant adolescents also reported higher level of parental control and lower levels of affiliation with deviant peers, but lower levels of child disclosure, parental solicitation and parental knowledge. Socio‐economic status and parental monitoring showed equivalent effects on drug use for immigrant and non‐immigrant adolescents. Results have implications for preventive interventions for immigrant adolescents and families, including the need to develop programmes that leverage the benefits of the immigrant paradox for immigrant communities. Future research should analyse the processes that lead to lower levels of drug use in immigrant adolescents and investigate the influence of friendship networks on immigrant adolescent drug use behaviour. Copyright © 2015 John Wiley & Sons, Ltd.     

Emerging perception of causality in action-and-reaction sequences from 4 to 6 months of age: Is it domain-specific?

Two experiments (N=136) studied how 4- to 6-month-olds perceive a simple schematic event, seen as goal-directed action and reaction from 3 years of age. In our causal reaction event, a red square moved toward a blue square, stopping prior to contact. Blue began to move away before red stopped, so that both briefly moved simultaneously at a distance. Primarily, our study sought to determine from what age infants see the causal structure of this reaction event. In addition, we looked at whether this causal percept depends on an animate style of motion and whether it correlates with tasks assessing goal perception and goal-directed action. Infants saw either causal reactions or noncausal delayed control events in which blue started some time after red stopped. These events involved squares that moved either rigidly or nonrigidly in an apparently animate manner. After habituation to one of the four events, infants were tested on reversal of the habituation event. Spatiotemporal features reversed for all events, but causal roles changed only in reversed reactions. The 6-month-olds dishabituated significantly more to reversal of causal reaction events than to noncausal delay events, whereas younger infants reacted similarly to reversal of both. Thus, perceptual causality for reaction events emerges by 6 months of age, a younger age than previously reported but, crucially, the same age at which perceptual causality for launch events has emerged in prior research. On our second question, animate/inanimate motion had no effect at any age, nor did significant correlations emerge with our additional tasks assessing goal perception or goal-directed object retrieval. Available evidence, here and elsewhere, is as compatible with a view that infants initially see A affecting B, without differentiation into physical or psychological causality, as with the standard assumption of distinct physical/psychological causal perception.     

Upward and downward comparison in the intermediate-status group: the role of social stratification stability

This work analyses intergroup comparison choices made by intermediate-status group members. Seventy-six psychology students were categorized in an intermediate position with respect to other faculties. Stability was manipulated at three levels: stable, upwardly unstable, and downwardly unstable. Data on strength of comparison, comparison for enhancing, comparison for evaluation, and ingroup identification were collected. Results revealed that in the stable condition, participants were equally engaged in both upward and downward comparison. In the upwardly unstable condition, participants were more likely to compare themselves with the high-status group, whereas in the downwardly unstable condition, they were more likely to choose a downward comparison. In this latter condition, both downward comparison for enhancement and in-group identification were lower than in other conditions.     

Measured and predicted mechanical internal work in human locomotion

Predictive methods estimating mechanical internal work (W_int, i.e., work to accelerate limbs with respect to BCOM during locomotion) are needed in absence of experimental measurements. A previously proposed model equation predicts such a parameter based upon velocity, stride frequency, duty factor, and a compound critical term (q) accounting for limb geometry and inertial properties. That first predicted W_int estimate (PW_int) has been validated only for young males and for a limited number of horses. The present study aimed to extend the comparison between model predictions and experimentally measured W_int (MW_int) data on humans with varying gender, age, gait, velocity, and gradient. Seventy healthy subjects (males and females; 7 age groups: 6-65 years) carried out level walking and running on treadmill, at different velocities. Moreover, one of the subject groups (25-35 years) walked and ran also at several uphill/downhill gradients. Reference values of q represent the main important results: (a) males and females have similar q values; (b) q is independent on velocity and gradient. Also, different data filtering depth was found to affect MW_int and, indirectly, PW_int, thus also the reference q values here obtained (0.08 in level, 0.10 in gradient) suffer a - 20% underestimation with respect to the previous predicting model. Despite of this effect, the close match between MW_int and PW_int trends indicates that the model equation could be satisfactorily applied, in various locomotion conditions.     

Neural correlates of infant accent discrimination: an fNIRS study

The present study investigated the neural correlates of infant discrimination of very similar linguistic varieties (Quebecois and Parisian French) using functional Near InfraRed Spectroscopy. In line with previous behavioral and electrophysiological data, there was no evidence that 3‐month‐olds discriminated the two regional accents, whereas 5‐month‐olds did, with the locus of discrimination in left anterior perisylvian regions. These neuroimaging results suggest that a developing language network relying crucially on left perisylvian cortices sustains infants’ discrimination of similar linguistic varieties within this early period of infancy.     

Italian Adaptation and Confirmatory Factor Analysis of the Full and the Short Form of the Posttraumatic Growth Inventory

This study was designed to adapt and to assess the reliability and factor structure of an Italian translation of the full and short form of the Posttraumatic Growth Inventory. A sample of 1,244 Italian adults who had experienced a range of adverse life events participated in this study. Five models of the underlying structure of the Posttraumatic Growth Inventory were tested via confirmatory factor analyses. Analyses of both the short and full form of the PTGI provided support for the original correlated five-factor structure. Multigroup confirmatory factor analysis supported the invariance of the Posttraumatic Growth Inventory across gender.     

Making our ends meet: shared intention,goal adoption and the third-person perspective

Mind reading (i.e. the ability to infer the mental state of another agent) is taken to be the main cognitive ability required to share an intention and to collaborate. In this paper, I argue that another cognitive ability is also necessary to collaborate: representing others’ and ones’ own goals from a third-person perspective (other-centred or allocentric representation of goals). I argue that allocentric mind reading enables the cognitive ability of goal adoption, i.e. having the goal that another agent’s achieve p because and as long as another agent has that goal that p. Having clarified the relevance of mutual goal adoption for acting jointly, I argue that when an intention is shared between several agents, each individual has an intention in favour of the joint action and one in favour of a joint mode of reasoning. This mode of reasoning is allocentric reasoning. Finally, I elaborate on the consequences of this view for the scientific study of human collaboration.     

Science at the Supermarket: Multiplication,Personalization and Consumption of Science in Everyday Life

Which is the kind science’s psychological guidance upon everyday life? I will try to discuss some issues about the role that techno-scientific knowledge plays in sense-making and decision making about practical questions of life. This relation of both love and hate, antagonism and connivance is inscribable in a wider debate between a trend of science to intervene in fields that are traditionally prerogative of political, religious or ethical choices, and, on the other side, the position of those who aim at stemming “technocracy” and governing these processes. I argue that multiplication, personalization and consumption are the characteristics of the relationship between science, technology and society in the age of “multiculturalism” and “multi-scientism”. This makes more difficult but intriguing the study and understanding of the processes through which scientific knowledge is socialized. Science topics, like biotech, climate change, etc. are today an unavoidable reference frame. It is not possible to not know them and to attach them to the most disparate questions. Like in the case of Moscovici’s “Freud for all seasons”, the fact itself that the members of a group or a society believe in science as a reference point for others, roots its social representation and the belief that it can solve everyday life problems.