Occupational stress in clinical nurses

The present study was based on an integrative work stress model proposed by Cooper and his associates (Cooper et al., 1988), which focused on stress perception and outcomes, as well as potential moderating variables such as personality and coping efforts. Specifically, this article examines occupational stress in clinical nurses who worked in various hospitals in southern Taiwan. When compared with Chinese industrial white and blue-collar workers, nurses experienced higher work stress, more physical and mental ill-health, lower job satisfaction, and also made more efforts to cope with work stress. There were also some interesting differences in types of stressors experienced by nurses and industrial workers.     

Are you talking to the future me? The moderator role of future self‐relevance on the effects of aging salience in retirement savings

Increasing the salience of aging has been shown to be a promising strategy to promote young adults' interest in saving for retirement. However, the processes responsible for this effect are still largely unknown. We hypothesize that increased savings choices will only occur when participants are also engaged in self‐relevant thoughts about their own future. Participants were exposed to a fictitious website advertising financial products. Study 1 (n = 78; M_age = 20.87) primed age salience and future self‐relevance orthogonally and showed that priming aging only caused increases in retirement investment decisions when self‐relevance was also high. Study 2 (n = 91; M_age = 23.40) tested whether the effects of age priming were due specifically to age or to a broader focus on the future. The study confirmed that investment decision effects are specific to exposure to the aging prime and not merely priming the future. The effects were also specific to investment in retirement funds and not just depositing money in a checking account. These findings have both theoretical and practical implications for the psychology of aging and retirement planning.     

The rosy side and the blue side of emotional brand attachment

This paper examines the rosy side (positive emotion) and the blue side (negative emotion) of brand attachment in consumer–brand relationships and their distinct motivational triggers. Adopting attachment theory, self‐determination theory, and the relationship investment model, this paper provides a richer understanding of the positivity and negativity of emotional brand attachment in terms of consequential branding outcomes. Two hierarchical constructs—autonomous and controlled motivations—are proposed and examined using partial least squares path modelling. Data were collected through a 3‐stage survey to gain 507 samples of customers' brand attachments to 9 international car brands. This research reveals that customers' positive‐side (rosy‐side) emotional brand attachments are driven by autonomous motivations including satisfying the intrinsic motivation of pursuing pleasure and fulfilling needs for self‐determination and self‐congruence in the car brand consumption context. Customers' negative‐side (blue‐side) emotional brand attachment reflects feelings of separation distress, anxiety, and sadness that are triggered by their controlled motivations in car brand consumption contexts. The results indicate that positive emotions (the rosy side) of brand attachment are a more effective predictor of brand repurchasing intentions and word‐of‐mouth behaviours than are negative emotions (the blue side) of brand attachment. This study applies Deci and Ryan's autonomous and controlled motivations to explain the positivity and negativity of consumers' emotional brand attachment in brand–consumer relationships.     

Dorsomedial prefrontal cortex 5-HT6 receptors regulate anxiety-like behavior

The dorsomedial prefrontal cortex (dmPFC) plays a very important role in decision-related and anxiety-related information processing. It has enriched 5-HT6 receptors; however, the precise role of dmPFC 5-HT6 receptors in anxiety remains to be fully investigated. In this study, we injected dmPFC with the 5-HT6 receptor agonist EMD 386088 and antagonist SB 271046 using stereotactic technology. 5-HT6 receptor activation in mice increased time spent in the center area on the open-field test, increased exploration of the open arms on the elevated plus maze test, and increased ratio on the social interaction test. 5-HT6 receptor inactivation induced the opposite effects. In brain slices, EMD 386088 decreased both spontaneous inhibitory postsynaptic currents (sIPSC) and spontaneous excitatory postsynaptic currents (sEPSC), while SB 271046 only increased sEPSC. These effects of EMD 386088 and SB 271046 could be reversed by the GABA_A receptor antagonist bicuculline (BMI) and positive allosteric modulator clonazepam (CLZ), respectively. Our results suggest that neurotransmission in the dmPFC by 5-HT6 receptor activation and inhibition may play an important role in anxiety-like behavior, and may provide new insight into the pathological mechanism and potential target of anxiety disorders.     

Anxiety sensitivity moderates the painful effects of feeling burdensome to others

Perceived burdensomeness (PB), the perception of being a burden to others, is associated with pain and physical symptoms. Anxiety sensitivity (AS), the fear of arousal-related sensations, arising from beliefs that the sensations may have adverse personal consequences (physical, cognitive, and social), may increase risk for pain responding, particularly in anxiety-provoking (e.g. socially threatening) contexts. Accordingly, individuals high in AS may have a stronger pain response when experiencing PB than those low in AS. Undergraduate participants (n = 262) completed the Anxiety Sensitivity Index (ASI-3), and then were randomly assigned to re-live an experience when they were either burdensome to others (burdensome condition) or contributed equally to a group (control condition). Both social and physical self-reported pain were assessed post-manipulation. Those high in AS reported significantly higher pain ratings in the burdensome condition than the control condition; for those low in AS, pain did not change across conditions. In particular, being fearful of the physical repercussions of anxiety (AS physical concerns) while also feeling burdensome to others was associated with greater physical pain. AS may exacerbate the already painful effects of feeling burdensome to others, and may have important implications for the development of future suicide- and pain-related interventions.     

Emotionally conditioning the target-speech voice enhances recognition of the target speech under “cocktail-party” listening conditions

Under a noisy “cocktail-party” listening condition with multiple people talking, listeners can use various perceptual/cognitive unmasking cues to improve recognition of the target speech against informational speech-on-speech masking. One potential unmasking cue is the emotion expressed in a speech voice, by means of certain acoustical features. However, it was unclear whether emotionally conditioning a target-speech voice that has none of the typical acoustical features of emotions (i.e., an emotionally neutral voice) can be used by listeners for enhancing target-speech recognition under speech-on-speech masking conditions. In this study we examined the recognition of target speech against a two-talker speech masker both before and after the emotionally neutral target voice was paired with a loud female screaming sound that has a marked negative emotional valence. The results showed that recognition of the target speech (especially the first keyword in a target sentence) was significantly improved by emotionally conditioning the target speaker’s voice. Moreover, the emotional unmasking effect was independent of the unmasking effect of the perceived spatial separation between the target speech and the masker. Also, (skin conductance) electrodermal responses became stronger after emotional learning when the target speech and masker were perceptually co-located, suggesting an increase of listening efforts when the target speech was informationally masked. These results indicate that emotionally conditioning the target speaker’s voice does not change the acoustical parameters of the target-speech stimuli, but the emotionally conditioned vocal features can be used as cues for unmasking target speech.     

Does midbrain urocortin 1 matter? A 15-year journey from stress (mal)adaptation to energy metabolism

This review summarizes some of the milestones of the research on the biological functions(s) of midbrain urocortin 1 (Ucn1) since its discovery 15 years ago. Detailed characterization of Ucn1 in the midbrain revealed its overall significance in food intake and regulation of homeostatic equilibrium and mood under stress. In addition, we have recently found a conspicuous alteration in midbrain Ucn1 levels in brains of depressed suicide victims. Furthermore, from the results from the genetically modified animals, a picture is emerging where corticotrophin-releasing factor promotes the initial reactions to stress, whereas Ucn1 seems to be crucial for management of the later adaptive phase. In the case of imbalance in action of these principle stress mediators, vulnerability to stress-related brain diseases is enhanced.     

Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

Evidence indicates that systemic administration of lipopolysaccharide (LPS) induces brain inflammation, ultimately resulting in cognitive deficits. Ursolic acid (UA), a plant-derived pentacyclic triterpenoid, is well known to possess multiple biological functions, including antioxidant, anti-tumor and anti-inflammatory activities. In the present study, we assessed the protective effect of UA against the LPS-induced cognitive deficits in mice. We found that UA significantly improved cognitive deficits of LPS-treated mice in open field, step-through passive avoidance and Morris water maze tasks. One potential mechanism of this action was attributed to the decreased production of pro-inflammatory markers including COX-2, iNOS, TNF-α, IL-1β, IL-2 and IL-6 in LPS-treated mouse brain. Mechanistically, UA markedly inhibited LPS-induced IκBα phosphorylation and degradation, NF-κB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-κB signaling pathways.     

Noise exclusion in spatial attention

Precue validity affects the performance of perceptual tasks. These spatial attention effects have been variously attributed to facilitation of processing, capacity allocation, or noise reduction. We used a new attention-plus-external (stimulus)-noise paradigm and model to identify the mechanisms of attention in cue-validity paradigms. A new phenomenon is reported: a large effect of location cue validity in an orientation identification task that specifically occurs when the stimulus is embedded in external (environmental or stimulus) noise. This result identifies the mechanism of the effect as external-noise exclusion, distinguished from stimulus enhancement that manifests itself only in noiseless stimulus environments.