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死后医疗数据捐赠对于科学研究的意义重大。但目前不存在有针对性的准则用于指导捐赠过程。如果死后医疗数据的使用缺乏监管可能会引发多种风险,一是给他人利益造成损害;二是造成数据的不规范使用。因此,应当类比现有捐献制度,允许并鼓励捐献死后医疗数据用于科学研究,并起草专门的捐赠准则。该准则的制定应当建立在遵循五大基本原则的前提下,主张以自愿参与的方式使用个人医疗数据,反对未经书面同意将数据用于以病例档案为基础的医学研究。
相似文献143.
地域歧视现象的存在是违背和谐社会理念的,人们对此现象是什么态度?研究以费施贝因和阿扎吉提出的理性行为模型理论为基础,选取网络上最活跃的大学生为样本,编制了大学生地域歧视现象态度量表,构建了对地域歧视现象态度、对地域歧视者态度和对被歧视者态度3个维度。通过整理访谈资料、参考相关量表、专家讨论等方法编制条目。选取358名被试进行预测试,617名被试正式测试。研究结果表明,大学生地域歧视现象态度量表建构的3个维度结构合理,量表的项目分析、探索性分析和验证性分析符合心理测量学要求,是测量中国大学生地域歧视现象态度的有效工具。 相似文献
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This paper examines the rosy side (positive emotion) and the blue side (negative emotion) of brand attachment in consumer–brand relationships and their distinct motivational triggers. Adopting attachment theory, self‐determination theory, and the relationship investment model, this paper provides a richer understanding of the positivity and negativity of emotional brand attachment in terms of consequential branding outcomes. Two hierarchical constructs—autonomous and controlled motivations—are proposed and examined using partial least squares path modelling. Data were collected through a 3‐stage survey to gain 507 samples of customers' brand attachments to 9 international car brands. This research reveals that customers' positive‐side (rosy‐side) emotional brand attachments are driven by autonomous motivations including satisfying the intrinsic motivation of pursuing pleasure and fulfilling needs for self‐determination and self‐congruence in the car brand consumption context. Customers' negative‐side (blue‐side) emotional brand attachment reflects feelings of separation distress, anxiety, and sadness that are triggered by their controlled motivations in car brand consumption contexts. The results indicate that positive emotions (the rosy side) of brand attachment are a more effective predictor of brand repurchasing intentions and word‐of‐mouth behaviours than are negative emotions (the blue side) of brand attachment. This study applies Deci and Ryan's autonomous and controlled motivations to explain the positivity and negativity of consumers' emotional brand attachment in brand–consumer relationships. 相似文献
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Fei Geng Jia Tian Jian-Lin Wu Yun Luo Wen-Jun Zou Chao Peng Gui-Feng Lu 《Cognitive, affective & behavioral neuroscience》2018,18(1):58-67
The dorsomedial prefrontal cortex (dmPFC) plays a very important role in decision-related and anxiety-related information processing. It has enriched 5-HT6 receptors; however, the precise role of dmPFC 5-HT6 receptors in anxiety remains to be fully investigated. In this study, we injected dmPFC with the 5-HT6 receptor agonist EMD 386088 and antagonist SB 271046 using stereotactic technology. 5-HT6 receptor activation in mice increased time spent in the center area on the open-field test, increased exploration of the open arms on the elevated plus maze test, and increased ratio on the social interaction test. 5-HT6 receptor inactivation induced the opposite effects. In brain slices, EMD 386088 decreased both spontaneous inhibitory postsynaptic currents (sIPSC) and spontaneous excitatory postsynaptic currents (sEPSC), while SB 271046 only increased sEPSC. These effects of EMD 386088 and SB 271046 could be reversed by the GABAA receptor antagonist bicuculline (BMI) and positive allosteric modulator clonazepam (CLZ), respectively. Our results suggest that neurotransmission in the dmPFC by 5-HT6 receptor activation and inhibition may play an important role in anxiety-like behavior, and may provide new insight into the pathological mechanism and potential target of anxiety disorders. 相似文献
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Angie S. LeRoy Qian Lu Michael J. Zvolensky Jeffrey Ramirez Christopher P. Fagundes 《Cognitive behaviour therapy》2018,47(2):126-138
Perceived burdensomeness (PB), the perception of being a burden to others, is associated with pain and physical symptoms. Anxiety sensitivity (AS), the fear of arousal-related sensations, arising from beliefs that the sensations may have adverse personal consequences (physical, cognitive, and social), may increase risk for pain responding, particularly in anxiety-provoking (e.g. socially threatening) contexts. Accordingly, individuals high in AS may have a stronger pain response when experiencing PB than those low in AS. Undergraduate participants (n = 262) completed the Anxiety Sensitivity Index (ASI-3), and then were randomly assigned to re-live an experience when they were either burdensome to others (burdensome condition) or contributed equally to a group (control condition). Both social and physical self-reported pain were assessed post-manipulation. Those high in AS reported significantly higher pain ratings in the burdensome condition than the control condition; for those low in AS, pain did not change across conditions. In particular, being fearful of the physical repercussions of anxiety (AS physical concerns) while also feeling burdensome to others was associated with greater physical pain. AS may exacerbate the already painful effects of feeling burdensome to others, and may have important implications for the development of future suicide- and pain-related interventions. 相似文献
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Does midbrain urocortin 1 matter? A 15-year journey from stress (mal)adaptation to energy metabolism
This review summarizes some of the milestones of the research on the biological functions(s) of midbrain urocortin 1 (Ucn1) since its discovery 15 years ago. Detailed characterization of Ucn1 in the midbrain revealed its overall significance in food intake and regulation of homeostatic equilibrium and mood under stress. In addition, we have recently found a conspicuous alteration in midbrain Ucn1 levels in brains of depressed suicide victims. Furthermore, from the results from the genetically modified animals, a picture is emerging where corticotrophin-releasing factor promotes the initial reactions to stress, whereas Ucn1 seems to be crucial for management of the later adaptive phase. In the case of imbalance in action of these principle stress mediators, vulnerability to stress-related brain diseases is enhanced. 相似文献
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