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261.
分析冠脉支架术对患者生活质量及心理情况的影响并探讨相应策略。采用横断面研究方法,调查2007年6月-2010年9月在我院行冠脉支架术患者768例,应用Zung焦虑、SAS、SDS自评表及SF-36生活质量问卷等方法采集相关资料,200名健康人为对照1组、未行支架置入的冠心病患者为对照2组,数据行统计学分析。支架植入患者... 相似文献
262.
Does midbrain urocortin 1 matter? A 15-year journey from stress (mal)adaptation to energy metabolism
This review summarizes some of the milestones of the research on the biological functions(s) of midbrain urocortin 1 (Ucn1) since its discovery 15 years ago. Detailed characterization of Ucn1 in the midbrain revealed its overall significance in food intake and regulation of homeostatic equilibrium and mood under stress. In addition, we have recently found a conspicuous alteration in midbrain Ucn1 levels in brains of depressed suicide victims. Furthermore, from the results from the genetically modified animals, a picture is emerging where corticotrophin-releasing factor promotes the initial reactions to stress, whereas Ucn1 seems to be crucial for management of the later adaptive phase. In the case of imbalance in action of these principle stress mediators, vulnerability to stress-related brain diseases is enhanced. 相似文献
263.
Jun Sung Hong Carl L. Algood Yu-Ling Chiu Stephanie Ai-Ping Lee 《Journal of child and family studies》2011,20(6):863-872
We review empirical studies on kinship foster care in the United States. We conceptualize kinship foster care within the context
of Urie Bronfenbrenner’s (1994) most recent ecological systems theory. Because there are multiple levels of influences on the developmental outcomes of
children placed in kinship foster home, understanding the interrelations between the individual (child) and his or her surrounding
environments (e.g., biological families, social-support network) is important. We argue that Bronfenbrenner’s most recent
ecological systems theory is an appropriate theoretical framework for policy and practice implications in addressing complex
issues surrounding kinship foster care system in the United States. This review integrates the empirical findings collectively
on the factors associated with kinship foster care within and between five systems levels of the ecological systems theory:
micro- (caregiver-child relationship, attachment, and kinship family environment), meso- (biological families), exo- (social-support network outside the family), macro- (race/ethnicity and policies), and chrono- (welfare reform) systems levels. Theories that are relevant to the ecological factors (e.g., attachment theory) are also
discussed. Finally, we draw policy and practice implications from the ecological systems analysis. 相似文献
264.
Wang YJ Lu J Wu DM Zheng ZH Zheng YL Wang XH Ruan J Sun X Shan Q Zhang ZF 《Neurobiology of learning and memory》2011,96(2):156-165
Evidence indicates that systemic administration of lipopolysaccharide (LPS) induces brain inflammation, ultimately resulting in cognitive deficits. Ursolic acid (UA), a plant-derived pentacyclic triterpenoid, is well known to possess multiple biological functions, including antioxidant, anti-tumor and anti-inflammatory activities. In the present study, we assessed the protective effect of UA against the LPS-induced cognitive deficits in mice. We found that UA significantly improved cognitive deficits of LPS-treated mice in open field, step-through passive avoidance and Morris water maze tasks. One potential mechanism of this action was attributed to the decreased production of pro-inflammatory markers including COX-2, iNOS, TNF-α, IL-1β, IL-2 and IL-6 in LPS-treated mouse brain. Mechanistically, UA markedly inhibited LPS-induced IκBα phosphorylation and degradation, NF-κB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-κB signaling pathways. 相似文献
265.
Visual search for a unique target is impaired when a salient distractor is presented (attentional capture). This phenomenon is said to occur because attention is diverted to a distractor before it reaches the target. Similarly, perception of the second of two targets embedded in a rapid stream of nontargets is impaired, suggesting attentional deprivation due to the processing of the first target (attentional blink). We examined whether these phenomena emerge from a common underlying attentional mechanism by using correlation studies. If these phenomena share a common foundation, the magnitude of these deficits should show within-subject correlations. Participants (N = 135) revealed significant attentional deficits during spatial and temporal capture and the attentional blink tasks. However, no significant correlation was found among these tasks. Experiment 2 (N = 95) replicated this finding using the same procedure as that used in Experiment 1 but included another attentional blink task that required spatial switching between the two targets. Strong correlations emerged only between the two attentional blink tasks (with/without spatial switching). The present results suggest that attentional deficits during spatial and temporal capture and the attentional blink tasks reflect different aspects of attention. 相似文献
266.
Na Young Shin Joon Hwan Jang Hee Sun Kim Geumsook Shim Jae Yeon Hwang Sung Nyun Kim Jun Soo Kwon 《Journal of Neuropsychology》2013,7(1):58-71
Background. Empirical evidence involving the processing of social information by patients with obsessive–compulsive disorder (OCD) has been relatively scarce. Our study investigated the perceptual abilities of patients with OCD to recognize human faces and bodies. Method. Fifty‐four drug‐free or drug‐naïve patients with OCD and 42 healthy controls performed discrimination tasks consisting of four types of stimuli: two sets of faces that were manipulated with regard to configuration and features, human bodies, and chairs. The stimuli were presented in upright and upside‐down orientations. Results. Patients with OCD were significantly less accurate in discriminating pairs of bodily postures implying actions. However, we found no significant differences between patient and control groups in the ability to recognize faces and chairs. The inversion effects for bodies and faces were also comparable between the two groups. Conclusions. The current findings suggest that patients with OCD experience difficulty in perceiving static forms of bodily postures, but are able to adequately recognize human faces. Our data indicate a selective deficit in the perception of bodily postures in those with OCD and suggest that this deficit is probably not related to the abnormal configurational processing of social objects. 相似文献
267.
Yuichiro Kikuno Tetsuro Matsunaga Jun Saiki 《Attention, perception & psychophysics》2013,75(7):1427-1437
The CHRNA4 gene is known to be associated with individual differences in attention. However, its associations with other cognitive functions remain to be elucidated. In the present study, we investigated the effects of genetic variations in CHRNA4 on rapid scene categorization by 100 healthy human participants. In Experiment 1, we also conducted the Attention Network Test (ANT) in order to examine whether the genetic effects could be accounted for by attention. CHRNA4 was genotyped as carrying the TT, CT, or CC allele. The scene categorization task required participants to judge whether the category of a scene image (natural or man-made) was consistent with a cue word displayed at the response phase. The target–mask stimulus onset asynchrony (SOA) ranged from 13 to 93 ms. In comparison with CC-allele carriers, CT- and TT-allele carriers responded more accurately at the long SOA (93 ms) only during natural-scene categorization. In contrast, we observed no consistent association between CHRNA4 and the ANT, and no intertask correlation between scene categorization and the ANT. To validate our natural-scene categorization results, Experiment 2, carried out with an independent sample of 100 participants and a different stimulus set, successfully replicated the association between CHRNA4 genotypes and natural-scene categorization accuracy at long SOAs (67 and 93 ms). Our findings demonstrate, for the first time, that genetic variations in CHRNA4 can moderately contribute to individual differences in natural-scene categorization performance. 相似文献
268.
门脉高压症治疗观点之辩 总被引:1,自引:0,他引:1
对立统一规律是辩证法的实质,在唯物辩证法的理论体系中占有核心地位。门脉高压症的外科治疗有分流术与断流术两种不同的手术方法,这两种方法从治疗机制上看是矛盾的,用对立统一观来认识这两种手术的联系并揭示门脉高压外科治疗发展的哲学依据。 相似文献
269.
Noise exclusion in spatial attention 总被引:5,自引:0,他引:5
Precue validity affects the performance of perceptual tasks. These spatial attention effects have been variously attributed to facilitation of processing, capacity allocation, or noise reduction. We used a new attention-plus-external (stimulus)-noise paradigm and model to identify the mechanisms of attention in cue-validity paradigms. A new phenomenon is reported: a large effect of location cue validity in an orientation identification task that specifically occurs when the stimulus is embedded in external (environmental or stimulus) noise. This result identifies the mechanism of the effect as external-noise exclusion, distinguished from stimulus enhancement that manifests itself only in noiseless stimulus environments. 相似文献
270.
马骏 《医学与哲学(人文社会医学版)》2000,21(5):13-14
国务院决定 ,在建立城镇职工医疗保障制度的同时 ,进行医药卫生体制改革 ,以建立适应社会主义市场经济要求的城镇医药卫生体制 ,促进卫生机构和医药行业健康发展 ,提高人民的健康水平[1 ] 。这是进入 2 1世纪我国卫生事业改革与发展面临的历史任务。1 深化改革的关键切入点我国卫生体制改革从 80年代开始 ,首先进行了医疗机构所有制结构调整 ,形成了以公有制为主、多种所有制并存的格局[2 ] ,从而促进了卫生事业的发展。同时 ,卫生事业单位为了适应社会主义市场经济体制 ,也在管理模式、运行机制、经济管理、人事制度等方面 ,采取了多种改… 相似文献