Training Genetic Counsellors to Deliver an Innovative Therapeutic Intervention: their Views and Experience of Facilitating Multi-Family Discussion Groups

Innovations in clinical genetics have increased diagnosis, treatment and prognosis of inherited genetic conditions (IGCs). This has led to an increased number of families seeking genetic testing and / or genetic counselling and increased the clinical load for genetic counsellors (GCs). Keeping pace with biomedical discoveries, interventions are required to support families to understand, communicate and cope with their Inherited Genetic Condition. The Socio-Psychological Research in Genomics (SPRinG) collaborative have developed a new intervention, based on multi-family discussion groups (MFDGs), to support families affected by IGCs and train GCs in its delivery. A potential challenge to implementing the intervention was whether GCs were willing and able to undergo the training to deliver the MFDG. In analysing three multi-perspective interviews with GCs, this paper evaluates the training received. Findings suggests that MFDGs are a potential valuable resource in supporting families to communicate genetic risk information and can enhance family function and emotional well-being. Furthermore, we demonstrate that it is feasible to train GCs in the delivery of the intervention and that it has the potential to be integrated into clinical practice. Its longer term implementation into routine clinical practice however relies on changes in both organisation of clinical genetics services and genetic counsellors’ professional development.     

Getting down and dirty: An exploration of participation in the field of obstacle challenges

This paper examines the contemporary phenomenon of obstacle challenges and why people participate in events that result in them getting soaking wet, freezing cold, and dirtier than they have ever been while also getting shot with pellets and receiving “electric shocks.” Many participants in these challenges have taken part numerous times and keep coming back for more. Using multiple research methods including questionnaires, participant observation where the author completed one of Ireland's more well‐known and “toughest physical and mental endurance challenges,” and also depth interviews with challenge participants has resulted in a rich and detailed account of the obstacle challenge experience. These events are so much more than a few hours of strenuous and muddy physical exercise. The sense of community and camaraderie that people experience during these challenges could be described as “transformative” with participants in many cases more rewarded and moved by this collaborative aspect than the gruelling physical endeavour that they undertake. The escapism provided by the experience is also one its main rewards, relief from the quotidian and the chance to just “be.” The servicescape proves to be critically important to the experience but in ways that are largely incompatible with research in this area to date in that the comfort and cleanliness expected of more traditional servicescapes are spurned and physical hardship is welcomed. As this is an exploratory and novel research topic, suggestions for further research are plentiful.     

What plausibly affects plausibility? Concept coherence and distributional word coherence as factors influencing plausibility judgments

Our goal was to investigate the basis of human plausibility judgements. Previous research had suggested that plausibility is affected by two factors: concept coherence (the inferences made between parts of a discourse) and word coherence (the distributional properties of the words used). In two experiments, participants were asked to rate the plausibility of sentence pairs describing events. In the first, we manipulated concept coherence by using different inference types to link the sentences in a pair (e.g., causal or temporal). In the second, we manipulated word coherence by using latent semantic analysis, so two sentence pairs describing the same event had different distributional properties. The results showed that inference type affects plausibility; sentence pairs linked by causal inferences were rated highest, followed by attributal, temporal, and unrelated inferences. The distributional manipulations had no reliable effect on plausibility ratings. We conclude that the processes involved in rating plausibility are based on evaluating concept coherence, not word coherence.     

Sexual harassment and social justice: reflections on the distance yet to go

Despite progress, protections remain inadequate for victims who bring legal claims of sexual harassment. The process for damages determination frequently increases harm and undercuts the policy initiatives enshrined in Title VII. The author critiques this process, focusing on misuse of psychological examinations and failure of the federal "rape shield" law to adequately protect plaintiffs. The author suggests possible reforms, including removing caps on Title VII damages, minimum awards (i.e., liquidated damages) upon proof of liability, and strategies for educating juries on the harms of harassment that do not exacerbate them, and concludes with a call for professional guidelines for conducting forensic evaluations in sexual harassment cases, thus advancing the policy goal of combating discrimination by encouraging victims to come forward.     

Learning- and grade-orientation,sex, and prediction of self-reported academic performance

148 undergraduate students completed the LOGO-II scale, a measure of educational orientation, i.e., learning-oriented and grade-oriented attitudes and behaviors, and were asked to report their current and expected grades, as well as their self-assessed academic skill. Generally, learning orientation was positively correlated with academic performance, but grade orientation was negatively correlated with performance. Learning orientation and grade orientation predicted academic performance for men but not women. Implications of these findings, including the possibility of encouraging students to assume a more learning-oriented approach to their education, are discussed.     

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

Metabotropic glutamate (mGlu) receptors, which include mGlu1-8 receptors, are a heterogeneous family of G-protein coupled receptors (GPCRs) that function to modulate neuronal excitation and plasticity via pre-synaptic, post-synaptic and glial mechanisms. Agonists for group II mGlu receptors (mGlu2 and mGlu3), such as LY354740, have been shown to suppress enhanced glutamatergic excitations in brain synapses known to be involved in the expression of fear/anxiety in animals and humans. Systemic administration of LY354740 increases open-arm time in the elevated plus maze in mice under conditions of moderate to severe stress, blocks the expression but not development of fear-potentiated startle in rats, prevents lactate-induced panic-like responses in panic-prone rats, and attenuates certain physiological, behavioral, and neurochemical consequences of acute stress in rodents. In these preclinical models, LY354740 does not produce the side-effects (e.g. sedation) that are associated with other anxiolytic agents such as benzodiazepines. Early clinical results with LY354740 have demonstrated safety and efficacy in a human anxiety model (panic provocation induced by CO2 challenge). Collectively, these data indicate mGlu2/3 receptor agonists such as LY354740 represent a promising new approach for treatment of anxiety and stress-related disorders in humans.     

Loneliness as a specific risk factor for depressive symptoms: cross-sectional and longitudinal analyses

The extent to which loneliness is a unique risk factor for depressive symptoms was determined in 2 population-based studies of middle-aged to older adults, and the possible causal influences between loneliness and depressive symptoms were examined longitudinally in the 2nd study. In Study 1, a nationally representative sample of persons aged 54 and older completed a telephone interview as part of a study of health and aging. Higher levels of loneliness were associated with more depressive symptoms, net of the effects of age, gender, ethnicity, education, income, marital status, social support, and perceived stress. In Study 2, detailed measures of loneliness, social support, perceived stress, hostility, and demographic characteristics were collected over a 3-year period from a population-based sample of adults ages 50-67 years from Cook County, Illinois. Loneliness was again associated with more depressive symptoms, net of demographic covariates, marital status, social support, hostility, and perceived stress. Latent variable growth models revealed reciprocal influences over time between loneliness and depressive symptomatology. These data suggest that loneliness and depressive symptomatology can act in a synergistic effect to diminish well-being in middle-aged and older adults.     

Loneliness is a unique predictor of age-related differences in systolic blood pressure

A population-based sample of Caucasians, African Americans, and Latino Americans, 50-68 years of age (M = 57.5), from Cook County, Illinois (N = 229), was tested to examine how loneliness and co-occurring psychosocial factors (depressive symptoms, perceived stress, social support, and hostility) were related to indices of cardiovascular and endocrine functioning. Extending prior research, the authors found that loneliness was associated with elevated systolic blood pressure (SBP) and age-related increases in SBP, net of demographic variables, health behavior variables, and the remaining psychosocial factors. Loneliness was not associated with differences in autonomic or endocrine functioning. Although the results are limited by the cross-sectional methods used, they are consistent with the hypothesis that cardiovascular disease contributes to increased morbidity and mortality among lonely individuals.     

Covariates of production and perseveration on tests of phonemic, semantic and alternating fluency in normal aging

Standard measures of phonemic and semantic fluency, as well as fluency measures that impose additional demands upon set-switching were administered to younger and older adults. No age effect was found for total output on semantic fluency, while older participants generated significantly more responses relative to their younger counterparts on the phonemic measure. However, older adults made significantly more perseverative errors on both these measures. For tests of alternating fluency, only where participants were required to switch between two semantic dimensions, was an age deficit observed. Although the correlation between phonemic repetitions and age remained significant when performance on the Digit Symbol Test or a measure of fluid intelligence was partialled out, age effects for semantic repetitions and semantic alternating fluency were substantially reduced. The age benefit for number of correct responses upon phonemic fluency was significantly attenuated when a measure of crystallized intelligence was entered as a control variable. The theoretical and practical implications of these results are discussed.