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Lorna M. Lopez William MullenPetra Zürbig Sarah E. Harris Alan J. Gow John M. Starr David J. Porteous Harald Mischak Ian J. Deary 《Intelligence》2011,39(1):46
Intelligence is an important indicator of physical, mental and social well-being. In old age, intelligence is also associated with a higher quality of life and better health. Heritability studies have shown that there are strong genetic influences, yet unknown, on intelligence, including in old age. Other approaches may be useful to investigate the biological foundations of intelligence differences. Proteomics is a proven technique in revealing biomarkers for certain illnesses. In this pilot study, forty individuals were selected as the cognitive extremes from over 750 people in the Lothian Birth Cohort 1936 (age ~ 72 years) based on their high and low intelligence scores, as measured by a general cognitive ability factor. Urine samples were used as a stable, reliable and abundant source of proteins. Using capillary electrophoresis coupled to mass spectrometry (CE-MS) technology, the proteome of the high and low intelligence groups was determined. Data were calibrated and matched against the human urinary database, to enable comparative assessment. At a nominal significance level (P < 0.05), there were several candidate proteins for association with intelligence, including a zinc finger protein (ZNF653) that has been associated with cognitive deficits, and complement C3 and collagen fragments that have been associated with Alzheimer's disease. Results are preliminary, do not survive multiple testing correction, and require validation. This pilot study shows the potential of this novel proteomics approach, and its applicability to understanding the biological foundations of intelligence differences. 相似文献
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A Cross‐National Comparison of Suicide Attempts,Drug Use,and Depressed Mood Among Dominican Youth 下载免费PDF全文
Juan B. Peña PhD LCSW Katherine E. Masyn PhD Lorna E. Thorpe PhD Stephanie M. Peña MSW Eric D. Caine MD 《Suicide & life-threatening behavior》2016,46(3):301-312
We compared suicide attempts, depressed mood, and drug use of 1,710 Dominican public high school students in New York City (NYC) and 9,573 in the Dominican Republic (DR) in 2009. Compared to DR Dominicans, NYC Dominicans were more likely to have reported lifetime marijuana use (27.6% vs. 1.5%), lifetime inhalant use (11.0% vs. 7.6%), lifetime other drug use (9.9% vs. 3.0%), depressed mood (31.3% vs. 27.2%), and suicide attempt (13.8% vs. 8.8%). The results of this study supported the hypothesis that substantial increases in illicit drug use, especially cocaine, heroin, ecstasy, and methamphetamines, among NYC Dominican youth account for their increased risk for suicide attempts compared to their DR Dominican counterparts. It also identified suicide attempts as a public health problem among NYC Dominicans, the largest NYC Latino immigrant population. 相似文献
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Robin G. Morris Robert T. Woods Kath S. Davies Jenny Berry Lorna W. Morris 《Counselling psychology quarterly》1992,5(4):337-348
The paper describes the development and evaluation of coping strategy focused courses for informal carers of dementia sufferers (The Ways of Coping Course). Carers who attended the courses were interviewed before, immediately after and three months later, measuring their coping strategies, level of depression and strain, knowledge concerning dementia and satisfaction with the courses. They were compared to a second group of carers who attended educationally-focused courses consisting of a series of seminars on dementia. Both groups showed a signijicant increase in problem focused and decrease in distancing coping strategies but no change in levels of depression or strain. The carers in the Ways of Coping group showed an increase in acting out behaviour immediately following the courses and also showed greater levels of satisfaction with the courses overall. 相似文献
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