Posttraining Electrical Stimulation of Vagal Afferents with Concomitant Vagal Efferent Inactivation Enhances Memory Storage Processes in the Rat

Peripherally administered or released substances that modulate memory storage, but do not freely enter the brain, may produce their effects on memory by activating peripheral receptors that send messages centrally through the vagus nerve. Indeed, vagus nerve stimulation enhances memory performance, although it is unclear whether this effect is due to the activation of vagal afferents or efferents. To eliminate the possible influence of descending fibers on memory storage processes, rats were implanted with cuff electrode/catheter systems along the left cervical vagus. Forty-eight hours following surgery, each animal received a 3.0-μl infusion (1.0 μl/min) of either lidocaine hydrochloride (75.0 mM) or isotonic saline below the point of stimulation. Animals were then trained 10 min later on an inhibitory-avoidance task with a 0.75-mA, 1.0-s foot shock. Sham stimulation or vagus nerve stimulation (0.5-ms biphasic pulses; 20.0 Hz; 30 s; 0.2, 0.4, or 0.8 mA) was administered immediately after training. Memory, tested 24 h later, was enhanced by stimulation whether descending vagus nerve fibers were inactivated or not. Both lidocaine- and saline-infused groups showed an intensity-dependent, inverted-U-shaped pattern of retention performance, with the greatest effect observed for 0.4 mA (U= 9,p< .05, andU= 7,p< .01, respectively). Additionally, animals that received lidocaine infusions, but no vagus nerve stimulation, showed impaired memory compared to the performance of saline-infused control animals (U= 11,p< .05). Together, these findings suggest that vagal afferents carry messages about peripheral states that lead to the modulation of memory storage and that the memory-enhancing effect produced by vagus nerve stimulation is not mediated via the activation of vagal efferents.     

Resurgence as Choice in Context: Treatment duration and on/off alternative reinforcement

Resurgence as Choice (RaC) is a quantitative theory suggesting that an increase in an extinguished target behavior with subsequent extinction of an alternative behavior (i.e., resurgence) is governed by the same processes as choice more generally. We present data from an experiment with rats examining a range of treatment durations with alternative reinforcement plus extinction and demonstrate that increases in treatment duration produce small but reliable decreases in resurgence. Although RaC predicted the relation between target responding and treatment duration, the model failed in other respects. First, contrary to predictions, the present experiment also replicated previous findings that exposure to cycling on/off alternative reinforcement reduces resurgence. Second, RaC did a poor job simultaneously accounting for target and alternative behaviors across conditions. We present a revised model incorporating a role for more local signaling effects of reinforcer deliveries or their absence on response allocation. Such signaling effects are suggested to impact response allocation above and beyond the values of the target and alternative behaviors as longer-term repositories of experience. The new model provides an excellent account of the data and can be viewed as an integration of RaC and a quantitative approximation of some aspects of Context Theory.     

Warren Zevon’s <Emphasis Type="Italic">The Wind</Emphasis> and Ecclesiastes: Searching for Meaning at the Threshold of Death

Telling one's story itself brings purpose to ones life, and it is an essential part of coming to grips with death. The book of Ecclesiastes and Warren Zevon’s album The Wind express the hope for social immortality rather than an actual afterlife. Both of them are suffused with a sense of death-awareness, although their location in time and place and the genre of their expressions are quite different. By looking closely at these texts, one is able to ascertain certain aspects of life review which are necessary for wholeness and completion. Hospice Chaplain CHRISTUS VNA Hospice and Palliative Care, 4415 Centerview, San Antonio, TX 78228, USA. Reverend Philip Browning Helsel is a hospice chaplain at CHRISTUS Hospice in San Antontio. He received his Master of Divinity from Princeton Theological Seminary and Clinical Pastoral Education units from Yuma Regional Medical Center in Yuma, AZ, and is an ordained minister in the Church of God (Anderson, IN). He has been a chaplain in psychiatric and general hospital settings. Past publications include articles in Pastoral Psychology and Presence, the Journal of Spiritual Directors International. He is working on a book about the life review process in literature and music, and applying for membership in the Association of Professional Chaplains.     

Collaboration and prospective memory: comparing nominal and collaborative group performance in strangers and couples

To perform prospective memory (PM) tasks in day-to-day life, we often enlist the help of others. Yet the effects of collaboration on PM are largely unknown. Adopting the methodology of the “collaborative recall paradigm”, we tested whether stranger dyads (Experiment 1) and intimate couples (Experiment 2) would perform better on a “Virtual Week” task when working together or each working separately. In Experiment 1, we found evidence of collaborative inhibition: collaborating strangers did not perform to their pooled individual potential, although the effect was modulated by PM task difficulty. We also found that the overall collaborative inhibition effect was attributable to both the retrospective and prospective components of PM. In Experiment 2 however, there was no collaborative inhibition: there was no significant difference in performance between couples working together or separately. Our findings suggest potential costs of collaboration to PM. Intimate relationships may reduce the usual costs of collaboration, with implications for intervention training programmes and for populations who most need PM support.     

Implications for the self determine benevolence and self-protection in intergroup relations

People often favor groups they belong to over those beyond the in-group boundary. Yet, in-group favoritism does not always occur, and people will sometimes favor an out-group over the in-group. We delineate theoretically when in-group favoritism (i.e., self-protection) and out-group favoritism (i.e., benevolence) should occur. In two experiments, groups’ relative status and competence stereotypes were manipulated; groups’ outcomes were non-contingent in Experiment 1 and contingent in Experiment 2. When allocating reward, members of a low-status group were self-protective, favoring the in-group over the out-group under both non-contingent and contingent outcomes. Those with high status benevolently favored the out-group when outcomes were non-contingent, but were self-protective with contingent outcomes. People were willing to engage in social activities with an out-group member regardless of competence. However, when task collaboration had implications for the self, those with low status preferred competent over less competent out-group members. Traits of high status targets were differentiated by those with low status in both experiments, whereas those with high status differentiated low-status members’ traits only when outcomes were contingent. A general principle fits the data: The implications of intergroup responses for the self determine benevolence and self-protection.     

Healthy Nests Transition to Parenthood Program: A Mixed-Methods Study

Intimate partner relationship distress is associated with a wide range of negative adult and child outcomes. The transition to parenthood is often a time in the life of a couple where relationship distress increases and satisfaction and intimacy decrease and thus is an ideal time for targeted intervention. The Healthy Nests (HN) intervention is a three-meeting, strength-focused couples intervention for first-time parents designed to decrease maladaptive relationship conflict and increase couple well-being. The authors conducted a mixed-methods exploratory study investigating participants' overall experiences with the HN intervention and measured outcomes associated with relationship satisfaction, help seeking, father involvement, substance use, and depression. A total of 130 parents (65 dyads) participated in a randomized intervention and educational materials–only alternative intervention. Twenty dyads were interviewed as a part of the qualitative portion of the study. While the authors did not find significant quantitative effects on key outcomes, the qualitative findings suggested that participants had a positive experience with the HN intervention and indicated it was useful to have designated time and space to communicate as a couple. Qualitative findings also suggest that the focus on “aspects of strength” and “areas of change” in their relationship was useful. Implications for practice, research, and training are discussed.     

黑格尔和马克思的无限：从无限概念到资本概念

作者认为,黑格尔善的无限性的本质就在于自身展开,并且生产出和再生产出自身的不同的表现形式,马克思在这方面深受黑格尔的影响,甚至《大纲》的主要基础都是由黑格尔奠定的.但却不能简单地将马克思等同于一般意义上的黑格尔主义者,马克思的发展或者说贡献在于,将黑格尔的基础运用到对资本主义的批判中去,并特别强调了劳动的社会意义.马克思看到了资本主义的根本问题在于资本自身再生产的过程,这一过程表面上看起来与善的无限自身发展过程相类似,却实际上具有恶的无限性的特征,因此这种生产方式是具备摧毁自身的力量的.在这一意义上,马克思对资本主义进行了批判,并提出了真正人的自由和社会自由的问题.     

LOVE AS SACRIFICE,LOVE AS MUTUALITY: RESPONSE TO JEFFREY TILLMAN

Jeffrey Tillman is perceptive in noticing that certain Protestant theologians have used evolutionary theory to become more sympathetic to Roman Catholic views of Christian love. But he is incorrect in saying that these formulations deemphasize a place for self‐sacrifice in Christian love. Christian love defined as a strenuous equal‐regard for both other and self also requires sacrificial efforts to restore love as equal‐regard when finitude and sin undermine genuine mutuality and community.     

Perseverative interference with object-in-place scene learning in rhesus monkeys with bilateral ablation of ventrolateral prefrontal cortex

Surgical disconnection of the frontal cortex and inferotemporal cortex severely impairs many aspects of visual learning and memory, including learning of new object-in-place scene memory problems, a monkey model of episodic memory. As part of a study of specialization within prefrontal cortex in visual learning and memory, we tested monkeys with bilateral ablations of ventrolateral prefrontal cortex in object-in-place scene learning. These monkeys were mildly impaired in scene learning relative to their own preoperative performance, similar in severity to that of monkeys with bilateral ablation of orbital prefrontal cortex. An analysis of response types showed that the monkeys with lesions were specifically impaired in responding to negative feedback during learning: The post-operative increase in errors was limited to trials in which the first response to each new problem, made on the basis of trial and error, was incorrect. This perseverative pattern of deficit was not observed in the same analysis of response types in monkeys with bilateral ablations of the orbital prefrontal cortex, who were equally impaired on trials with correct and incorrect first responses. This may represent a specific signature of ventrolateral prefrontal involvement in episodic learning and memory.