Disclosure of Genetic Research Results to Members of a Founder Population

There is currently extensive discussion and debate in the literature on how, when, and to whom genetic research results should be returned (see Genetics in Medicine, April 2012 issue). Here, we describe our experience in disclosing genetic information on Mendelian disorders discovered during the course of our research in the Hutterites. We first assessed attitudes toward the disclosure of carrier results, which revealed that many individuals wanted carrier information and that many intended to use the information in family planning. Based on this information, we developed a pilot study to test and disclose cystic fibrosis (CF) carrier status. Next, a larger scale project was developed in order to disclose genetic research results for 14 diseases to those interested in receiving the information. We developed brochures, offered a live interactive educational program, conducted a consent process, and disclosed results in letters mailed to the consented individuals. Overall, ~80 % of individuals who participated in the educational program signed consent forms for the release of their results for 14 diseases. We describe our experience with returning individual genetic research results to participants in a population-based research study.     

Cultural influences on willingness to seek treatment for social anxiety in Chinese- and European-heritage students

We examined culture-related influences on willingness to seek treatment for social anxiety in first- and second-generation students of Chinese heritage (Ns=65, 47, respectively), and their European-heritage counterparts (N=60). Participants completed measures that assessed their willingness to seek treatment for various levels of social anxiety. Results showed that participants were similar on willingness to seek treatment at low- and high-severity levels of social anxiety; however, at moderate levels, first-generation Chinese participants were significantly less willing to seek treatment compared to their European-heritage counterparts. The reluctance of first-generation Chinese participants to seek treatment was associated with greater Chinese-heritage acculturation, and was not related to perceiving symptoms of social anxiety as less impairing. The findings support the general contention that Asians in North America tend to delay treatment for mental health problems.     

Community Violence as It Affects Child Development: Issues of Definition

The state of the art of definition of community violence as it relates to child development was examined in terms of the definitions used in 23 empirical studies. In all cases community violence was defined in terms of what were assumed to be measurements obtained as linear combinations of a priori numerical weighting of responses to questions--asked either of a child or of the parent of a child--about experiencing and/or witnessing and/or hearing about instances of violence. Thus, the definitions can be seen to represent the perspectives of 2 kinds of observers--the child or the child's parent--and 3 levels of closeness to violence--experiencing, witnessing, or hearing about violence. Combining these perspectives and levels, the following 8 different definitions could be seen to be used in the practice of 1 or more of the 23 empirical studies: Child Self-Report (perception) of either (1) experiencing, or (2) witnessing, or (3) experiencing and witnessing, and hearing about violence; or Parent Report (perception) of the Child (4) experiencing, or (5) witnessing, or (6) experiencing and witnessing and hearing about violence, or (7) = (1) + (4), or (8) = (3) + (6). In almost all the examples of research definitions it was assumed implicitly and without test of the assumption that different violent events were interchangeable, and usually it was assumed (again without test) that the magnitudes of different violence events were equal. Usually, an unstated theory of stress appeared to guide the measurement definition, but in one study definitions were developed and tested in terms of a clearly-stated theory of learning. It was concluded that definition of community violence is a measurement problem; that very likely it is multidimensional; that it could be more nearly solved if better attention were given to specifying it in terms of theory that can be put to test and by attending to basic assumptions and principles of measurement.     

Cohesion and adaptability among individuals under treatment for infertility

The objective of this study was to evaluate cohesion and adaptability as relationship patterns of individuals in the presence or absence of infertility. Infertile subjects (20 men and 26 women, age 29.9 yr., SD = 3.8), and 100 fertile individuals (52 men and 48 women, age 29.5 yr., SD = 3.6) were included in this cross-sectional study conducted in Brazil. Subjects were married for the first time and had no children. The pattern of relationship (cohesion and adaptability) was assessed on the Family Adaptability and Cohesion Evaluation Scale (FACES III). Subjects were also interviewed and the interviews tape-recorded and analyzed by independent and blinded senior psychiatrists. The concepts of cohesion and adaptability did not differentiate infertile couples from fertile ones. Further, the recorded interviews also resulted in heterogeneous. nonconcordant judgments. These results lead to two conclusions: that awareness of infertility is not present in the population studied or that it is present but the magnitude of its effect is quite small and that FACES III and the interview focus on adaptability and cohesion are not sensitive enough to measure the difficulties in these couples' relationships. This leads us to reflect on the type of psychiatric support available to infertile couples.     

‘I was seeing more of her’: international counselling trainees' perceived benefits of intercultural clinical practice

Counsellor education in Britain is steadily turning into a multicultural environment. The limited relevant literature focuses on the challenges that ‘culturally different’ and international trainees may encounter. The aim of this paper is to elucidate a rarely exposed aspect of international counselling trainees' training experience, namely, the benefits they identify in practising across languages and cultures during placement. The illustration of this positive perspective is pertinent to the profession, as it expands existing knowledge on international trainees' experience of clinical practice and it challenges the prevailing conceptualisation of this situation as potentially problematic. It is argued that a shift towards a more holistic understanding of this population's counselling experiences is likely to have particularly useful implications for counsellor education and the profession more broadly.     

Schizotypy and pathological personality profile in siblings of patients with psychosis

Schizotypy has been proposed to be the expression of the genetic vulnerability to schizophrenia. Schizotypal features have been associated with personality dimensions found in patients with psychosis. In this study, we compared the Dimensional Assessment of Personality Pathology - Basic Questionnaire (DAPP-BQ) scores of patients with psychosis, siblings scoring higher on schizotypy (SSHS), and siblings scoring lower (SSLS). The SSHSs displayed a DAPP-BQ profile characterized by high scores in the dimensions of affective lability, anxiousness, submissiveness, social avoidance, identity problems, oppositionality, narcissism, and restricted expression, distinguishing them from the SSLS. Due to these dimensions, SSHSs are more similar to the patients' DAPP-BQ profile. The results suggest that this pathological personality profile might contribute to increase the risk of developing psychosis in siblings who have more schizotypal features.     

An exploration of afterlife beliefs in religiously-and secularly-oriented adults

One of the ways that religion helps individuals to find meaning and purpose in life is through the enrichment of the concept of an afterlife. Afterlife beliefs are more likely to be held by religious than non-religious individuals. However, research findings also suggest that even individuals that are self-characterised as non-religious, also endorse the continuation of several psychological states in the afterlife. The present study aimed to investigate whether secularly- and religiously-oriented individuals hold one, common representation about the afterlife or if more than one concepts of afterlife exist. One-hundred and seventy-five adults participated in the study (97 females). Participants were interviewed individually with a vignette and a questionnaire that explored the endorsement of perceptual, psychobiological and emotional capacities, desires, and communication aspects of a dead agent and to provide justification for their answers. Their level of religiosity was also assessed. All participants were Greeks and members of the Greek Orthodox Church. By applying a Two-Step Cluster Analysis, we identified four clusters/representations of the afterlife that range from the conception of death as the end of human existence to the conception of an afterlife where numerous human capacities continue to exist. Religious orientation related to the four conceptions in different ways.     

Performance of chronotypes on memory tests during the morning and the evening shifts

Memory consists of several phases or processes that can be influenced by many factors, including the individual's circadian rhythm and the time of day at which tests are performed. The present objective was to evaluate the performance on memory tests of different chronotypes during the morning and the evening shifts. Subjects (21 men and 26 women, between the ages of 20 and 35 yr.) were evaluated for memory and metamemory differences in the morning and in the afternoon, using a battery of neuropsychological tests composed of the Word List with Emotional Content, Visual Memory, Scale-Semantic Memory, Digit Span, Word-Pairs Associated, Verbal Fluency Test, and Metamemory questionnaire. In the evening shift, there was a statistical difference among chronotypes on the Word List with Neutral Content and on the Verbal Fluency Test. In the morning, there were no statistically significant differences; however, the morning-type subjects had higher scores on the metamemory tests (p<.01), while the evening-type subjects had higher scores in the afternoon (p<.01). In spite of their perception, on Word-Pairs Associated and Word List with Emotional Content, the subjects, independently of their chronotype, showed better performance by the evening than by the morning shift. These results highlight the importance of controlling the shift of day and chronotype in studies with the objective of exploration of human performance.