靶向药物不良反应的认识与思考

新的靶向药物出现提高了抗癌疗效,降低了毒性,使转移性恶性肿瘤患者从治疗中获益。靶向药物耐受性好,通常出现轻微或中度的毒副反应。尽管大多数不良反应是可以得到迅速处理的,但是严重的甚至危及生命的不良反应仍能够发生。因此,为更好地指导临床实践工作,该文综述了实体瘤治疗中常用靶向药物的主要不良反应和安全数据,并按照药物的作用靶...     

Chained and tandem scheduling with children

Children 4 to 7 yr in age were reinforced with trinkets and pennies on chained and tandem schedules. The schedules used were chain DRL FR, chain DRO FR, chain FI FR, tand FI FR, and tand DRO FR. Chain DRL FR and chain DRO FR schedules almost always produced strong schedule and stimulus control, but chain FI FR schedules rarely did if additional techniques were not used. Strong control was produced with chain FI FR schedules, however, if: (a) the FR component was increased in size; (b) schedule and stimulus control was first established with chain DRL FR or chain DRO FR schedules before shifting to the chain FI FR; or (c) an external clock was attached to the FI. Tand FI FR schedules never produced regular or repeatable patterns of responding when additional procedures were not used. Rate patterns resembling those of chain FI FR schedules were produced by tand FI FR schedules, however, if: (a) an external clock was attached to the FI component or (b) control was established by means of tand DRO FR schedules before the tand FI FR was used. Stimulus control was found to be exercised by specific visual stimuli, change of stimuli, and schedule order. Control exercised by schedule order was probably mediated by the child's own behavior which had assumed discriminative stimulus properties.     

Aging and the perception of biological motion

Two experiments examined how observers' ability to perceive biological motion changes with increasing age. The observers discriminated among kinetic figures, depicting walking, jogging, and skipping. The direction, duration, and temporal correspondence of the motions were manipulated. Quantitative differences occurred between the recognition performances of younger and older observers, but these differences were often modest. The older and younger observers' performances were comparable for most conditions at stimulus durations of 400 ms. The older observers also performed well above chance at shorter durations of 240 and 120 ms. Unlike their performance on other 2- or 3-dimensional motion tasks, older observers' ability to perceive biological motion is relatively well preserved.     

TRAINING AND GENERALIZATION OF SEXUAL ABUSE PREVENTION SKILLS FOR WOMEN WITH MENTAL RETARDATION

Previous research has shown that behavioral skills training to teach sexual abuse prevention skills to women with mental retardation results in skill acquisition but poor generalization. In this investigation we evaluated procedures for enhancing generalization following training. Five women with mental retardation received 10 behavioral skills training sessions followed by in situ training when the skills did not fully generalize. Behavioral skills training resulted in skill acquisition and in situ training produced generalized responding during naturalistic assessments.     

ANALYSIS OF WORK GROUP PRODUCTIVITY IN AN APPLIED SETTING: APPLICATION OF A TIME SERIES PANEL DESIGN

We provide a demonstration of a time series panel analysis applied under typical field research conditions characterized by (a) a small number of groups (b) all of which experience an intervention (thus there is no traditional control group), and (c) perform noncomparable tasks. The time series techniques allow a direct test of Naylor, Pritchard, and Ilgen's (1980) theory of behavior in organizations applied to work group productivity in a large-scale study of work groups conducted by Pritchard and colleagues (1989). The responses of 5 work groups to priority scores for 37 indicators of productivity over 23 months were used to predict month-by-month changes in productivity for each of the 37 group products. The results show that group productivity improvements can be explained by feedback including priority scores derived from nonlinear contingency functions of the productivity indicators. Furthermore, groups differed in their response to priority feedback. Goal setting positively affected productivity gain consistently across work groups, after the effects of priority feedback and the interaction of work groups with priority feedback were accounted for. Implications for group performance strategies and appropriate applications of the time series panel analysis are discussed.     

Evaluation of a sexual abuse prevention program for adults with mental retardation.

Programs to teach sexual abuse prevention skills to persons with mental retardation have rarely been evaluated empirically, and typical evaluations are limited to assessment of the participants' knowledge rather than their performance of specific skills. In the present study, 6 adult women with mental retardation were trained in sexual abuse prevention, and performance was assessed using four separate measures: pretests and posttests of knowledge, verbal report, role play, and naturalistic probes. All women learned the skills but failed to exhibit them to criterion during the probes. We discuss the implications for further training and assessment of sexual abuse prevention skills.     

Correlates of Satisfaction with a Peer Evaluation System: Investigation of Performance Levels and Individual Differences

The present research examined the effects of performance level and individual differences on participants' satisfaction with a peer evaluation system. One hundred and fifty-three individuals working in groups completed a questionnaire assessing self-monitoring, self-esteem, and individualism. A peer evaluation system was used at the end of the project. Subjects indicated their satisfaction with and reaction to the peer evaluation system. The findings demonstrated that performance level, individualism, self-esteem, and self-monitoring helped to understand and to predict group members' reactions to the peer evaluation system. Implications for future research and implementation of peer rating systems are discussed.     

Where did I park? A naturalistic study of spatial memory

A naturalistic study of spatial memory having temporary utility was conducted using 32 faculty and staff of a university, who park in non-reserved parking spaces, as subjects. The subjects, who were unaware of the study until interviewed, were asked to indicate on a map the exact location where they had parked their car on that day and on each of the three preceding days. Whereas retention accuracy decreased significantly across days, the recency effect was weak and overall retention proved to be very accurate. Of the subjects who varied their parking location, 88 per cent were able to indicate within three spaces where they parked on the day of the interview, and 58 per cent on the most remote day. Younger females made significantly larger retention errors across the four days than older females and younger and older males. Subjects' overall retention accuracy correlated with their overall confidence in their recollections (γ = .72). Daily ratings of ‘how busy on the job’, reported times left campus each day, parking location variability, particular parking lot used, and number of parking spaces in the distinct locations used were not significantly correlated with retention errors. In follow-up interviews, subjects reported preferring a behavioural, ‘park in a favourite spot’ strategy, with several types of imagery-based cognitive strategies being cited less frequently, and verbal encoding being the least often cited strategy.     

贫困对儿童心理健康的影响及其内在机制

儿童贫困问题是世界范围内的一个重大公共卫生问题。近几十年来,国内外的研究发现贫困对儿童的消极心理健康状态和积极心理健康状态均会产生影响。研究者试图从家庭和社会两个层面来解释贫困对儿童心理健康的影响,以揭示其内在影响机制。未来的研究应加强贫困儿童心理健康发展过程中的保护因素研究,探索儿童期贫困对个体心理健康的长期影响及其成因,进一步在我国社会文化背景下开展本土化研究,为实践上的预防和干预提供帮助。