Dopaminergic modulation of prospective memory in Parkinson's disease

Growing interest is present in literature on the study of prospective memory functioning in Parkinson's disease (PD). Current data indicate that prospective memory may be impaired in PD and a relationship with general executive dysfunctioning has been suggested. However, although the dopamine dependency of cognitive dysfunction in PD has been widely investigated, poor is known on the dopaminergic modulation of PM. In the present study we explored the effect of acute administration of levodopa on the performance of a PD sample (n=20) in a time-based prospective memory task. PD patients were evaluated in the morning after a 12-hour therapy wash-out in two experimental conditions: i) after levodopa assumption ("on"); ii) without drug administration ("off"). The experimental task required to execute three uncorrelated actions after 10' for three consecutive trials. Distinct scores for the spontaneous recall of the intention to perform the actions (prospective component) and for the correct execution of the actions (retrospective component) have been computed. Results showed that in the "off" condition PD patients were selectively impaired on the prospective component of the task. However, L-dopa administration significantly improved PD patients' performance actually restoring the prospective memory deficit. These results support a critical role of dopaminergic modulation in prospective memory processes in PD patients, possibly through the replacement of dopamine levels in fronto-striatal pathways.     

Multimodal communication and spatial binding in pied currawongs (<Emphasis Type="Italic">Strepera graculina</Emphasis>)

To make accurate assessments about their environment, animals must integrate a variety of sensory cues into a single unified percept. The effects of redundant multimodal signaling may be equivalent to the responses elicited by each individual cue, or enhanced when cues are combined. Binding of two seemingly coupled cues can persist despite small spatial and temporal discrepancies in signal presentation, a phenomenon termed the ventriloquist effect. Our study had two aims: first, to test the cognitive ability of a territorial, forest-dwelling bird to bind two spatially disparate cues; and second, to define the processing of the acoustic and visual cues as having either equivalent or enhanced effects when presented together. We broadcasted pied currawong (Strepera graculina) vocalizations alone or in the presence of a model currawong situated either adjacent to, or far away from a speaker, to free-living currawongs. The number of locomotive events and the average standard deviation in the distance from the speaker maintained by the focal currawong were greater in response to "far" than "close" treatments. Additionally, the average standard deviation of the distance to speaker for the uni-modal, speaker only treatment was similar to "far" responses. These findings support our hypothesis that currawongs cognitively bind two stimuli in close spatial proximity. In nature, this would result in an enhanced level of response toward territorial intruders. Our study was novel in its attempt to assess cognitive processes involved in the integration of spatially disparate bimodal signaling events in free-living birds.     

Pointing movements both impair and improve visuospatial working memory depending on serial position

Two experiments investigated the effects of pointing movements on the item and order recall of random, horizontal, and vertical arrays consisting of 6 and 7 squares (Experiment 1) or 8 and 9 squares (Experiment 2). In the encoding phase, participants either viewed the items passively (passive-view condition) or pointed towards them (pointing condition). Then, after a brief interval, they were requested to recall the locations of the studied squares in the correct order of presentation. The critical result was that, for all types of arrays, the effects of the encoding condition varied as a function of serial position: for the initial and central positions accuracy was higher in the passive-view than in the pointing condition (confirming the standard inhibitory effect of pointing movements on visuospatial working memory), whereas the reverse pattern occurred in the final positions—showing a significant advantage of the pointing condition over the passive-view condition. Findings are interpreted as showing that pointing can have two simultaneous effects on the recall of spatial locations, a positive one due to the addition of a motor code and a negative one due to the attentional requirements of hand movements, with the net impact on serial recall depending on the amount of attention resources needed for the encoding of each position. Implications for the item-order hypothesis and the perceptual-gestural account of working memory are also discussed.     

Irrational and Metacognitive Beliefs Mediate the Relationship Between Content Beliefs and GAD Symptoms: A Study on a Normal Population

Cognitive Behavioral Therapy (CBT), Rational Emotive Behavior Therapy (REBT) and Metacognitive Therapy (MCT) models show both similarities and differences in conceptualizing anxiety. This work assumes that REBT’s irrational and MCT’s metacognitive beliefs play a mediation role while CBT’s disorder specific content beliefs act as triggers. This hypothesis is tested using a regression model in which metacognitive and irrational beliefs play a mediation role while content disorder beliefs are independent variables. This paper applied this model to generalized anxiety disorder (GAD), a psychiatric diagnosis in which anxiety is the major feature. In GAD, the specific content beliefs are negative problem orientation and intolerance of uncertainty. Therefore, 149 non clinical subjects completed 4 self-report questionnaires: the Negative Orientation to the Problems Questionnaire and the Intolerance of Uncertainty Scale as measures for content cognitive beliefs, the Attitudes and Beliefs Scale for irrational beliefs, and the Metacognitive Questionnaire 30 Items Version for metacognitive beliefs. The generalized anxiety disorder questionnaire was chosen in order to measure anxiety as dependent variable. Regression analyses confirmed that irrational and metacognitive beliefs mediate the relation between cognitive content beliefs and GAD. We clinically interpret mediation as a second level regulation.     

A Pilot Study Implementing Coping Power in Italian Community Hospitals: Effect of Therapist Attachment Style on Outcomes in Children

The study presented the initial report of a project regarding the implementation of the Coping Power Program in Italian community hospitals, and the program’s ability to reduce externalizing behavioral problems in children with a Disruptive Behavior Disorder diagnosis. Usually, interventions for children are implemented by a number of therapists with different personal characteristics, which therefore influence the implementation quality of an intervention. That said, the present study aimed to establish whether the insecure attachment styles of therapists predict unfavorable outcomes for children treated with the Coping Power Program. The sample included 80 children with a Disruptive Behavior Disorder diagnosis and 16 therapists. The results showed that the change in children’s aggressive behavioral problems was significantly related to the levels of the therapist’s preoccupation with relationships. Higher levels of change in aggression (where a higher value means that the aggression at the end of the treatment is higher than aggression at the baseline evaluation) are associated with higher levels of therapist’s preoccupied attachment style (anxious attachment style). This study provided some preliminary evidence that therapists need to be sensitive to their own attachment experiences when delivering therapy for children.     

Preflexes and internal models in biomimetic robot systems

The next generation of neuroprostheses, which are aimed at the restoration of natural movement of paralysed body parts or at the natural interaction with external devices, will be quite similar to biomimetic robot systems which attempt to duplicate the organization of the biological motor control system. In the paper, we review some of the organizing principles that have emerged in the last few years and might provide useful guidelines for a biomimetic design.     

The role of the self in mindblindness in autism

Since its inception the 'mindblindness' theory of autism has greatly furthered our understanding of the core social-communication impairments in autism spectrum conditions (ASC). However, one of the more subtle issues within the theory that needs to be elaborated is the role of the 'self'. In this article, we expand on mindblindness in ASC by addressing topics related to the self and its central role in the social world and then review recent research in ASC that has yielded important insights by contrasting processes relating to both self and other. We suggest that new discoveries lie ahead in understanding how self and other are interrelated and/or distinct, and how understanding atypical self-referential and social-cognitive mechanisms may lead to novel ideas as to how to facilitate social-communicative abilities in ASC.     

Parents of Adolescents with Mental Disorders: Improving Their Caregiving Experience

Several studies have demonstrated that the family members of adolescents with mental diseases experience distress, anxiety and depression, as well as economic strain, all of which contribute to physical and psychological caregiver morbidity. The aim of this study was to assess the effectiveness of intervention to improve the caregiving experience of the parents of mentally ill adolescents. The parents of 20 patients were assessed with the Experience of Caregiving Inventory (ECI) and the Working Alliance Inventory (WAI), while patients’ functioning and psychopathology were evaluated with the Global Assessment of Functioning (GAF) scale and the Child Behavior Check List (CBCL), respectively. Assessments were conducted over 9 months, comparing the experimental group receiving the intervention with a control group that received “standard” care. While there were no significant differences in the patients’ psychopathologies, the caregivers in the experimental group had better ECI and WAI scores. Intervention focusing on the parents seemed to improve the caregivers’ understanding of the disease’s impact on their lives irrespective of the severity of their children’s condition. This finding may be useful in developing adequate measures for the parents of adolescents with severe mental diseases to help contain their psychological distress.