This study sought to identify brain regions that underlie symptom changes in severely affected IBS patients undergoing cognitive therapy (CT). Five healthy controls and 6 Rome II diagnosed IBS patients underwent psychological testing followed by rectal balloon distention while brain neural activity was measured with O-15 water positron emission tomography (PET) before and after a brief regimen of CT. Pre-treatment resting state scans, without distention, were compared to post-treatment scans using statistical parametric mapping (SPM). Neural activity in the parahippocampal gyrus and inferior portion of the right cortex cingulate were reduced in the post-treatment scan, compared to pre-treatment (x, y, z coordinates in MNI standard space were -30, -12, -30, P=0.017; 6, 34, -8, P=0.023, respectively). Blood flow values at these two sites in the controls were intermediate between those in the pre- and post-treatment IBS patients. Limbic activity changes were accompanied by significant improvements in GI symptoms (e.g., pain, bowel dysfunction) and psychological functioning (e.g., anxiety, worry). The left pons (-2, -26, -28, P=0.04) showed decreased neural activity which was correlated with post-treatment anxiety scores. Changes in neural activity of cortical-limbic regions that subserve hypervigilance and emotion regulation may represent biologically oriented change mechanisms that mediate symptom improvement of CT for IBS. 相似文献
This study examined correlates of maternal acceptance of preschool children in a sample of Mexican-American migrant farmworker mothers, including problems in life conditions (education, employment, relatives, friends, partner/spouse, children, health, housing, and finances) and social support (task, emotional, source, satisfaction, accessibility). One hundred Mexican-American mothers of preschoolers who participated in the Texas Migrant Council's Headstart Program were interviewed with regard to demographic information, social support, and problems in life conditions. The results supported the hypothesis that total social support accounts for more variation in maternal acceptance/rejection than problems in life conditions alone. Social support accounted for 75% of the variance in maternal acceptance/rejection of preschool children, and accessibility to support predicted the largest proportion of the variance. The results suggest that it is important to identify Mexican-American migrant farmworker mothers isolated from social support, since such isolation, in combination with problems in life conditions, places their children at higher risk for maternal rejection. 相似文献
Studies have suggested that early postnatal lesions are associated with a greater likelihood of atypical speech representation than lesions acquired later in life. Comparison groups have been defined differently across studies, with age typically being treated as a dichotomous (i.e., early versus late lesion onset) rather than continuous variable. Thus, little is known about the age at which children become less likely to exhibit atypical representation following a brain insult. This study examined the likelihood of typical versus atypical speech representation in children with intractable epilepsy (n = 75). Age of seizure onset was treated as a continuous variable to examine whether there was a naturally occurring cut-off point after which the rate of atypical speech representation decreased. A much higher proportion of children with seizure onset prior to the fifth year showed atypical speech representation as compared to children whose seizures began after 5 years of age. 相似文献
The present article reports on the development and validation of two self-report instruments designed to assess the symptoms and cognitions associated with panic attacks. The Panic Attack Symptoms Questionnaire (PASQ) as well as the Panic Attack Cognitions Questionnaire (PACQ) successfully differentiated a group of anxiety-disordered individuals with panic attacks from a group of anxiety-disordered individuals without panic attacks. Reliability estimates based on Cronbach's alpha were adequate, and two discriminant functions designed to determine whether each of these questionnaires contributed uniquely to the separation of individuals with and without panic attacks beyond that provided by standard measures of anxiety and depression supported the validity of these questionnaires. The PASQ and PACQ appear to be useful vehicles for assessing the presence and severity of panic attacks. 相似文献
There are few psychometrically sound measures of coping in adults. Widely used measures of coping have highly unstable sub-scale analyses, were developed on homogenous samples, and are outdated. The scarcity of empirically derived instruments is concerning given that coping skills are linked to a variety of positive and negative physical and mental health outcomes (e.g., substance use, depression). Thus, the aim of the current study was to develop a psychometrically sound measure of coping in adults: the Adult Coping Inventory (ACI). The study consisted of three phases: The aim of Phase 1 was to generate an initial item pool. After eliminating redundant items, 124 items remained. The purpose of Phase 2 was to eliminate items based on item frequency and factor loadings. A diverse sample of 526 adults participated in the study. Following item generation and elimination, an exploratory factor analysis produced a 57-item, five-factor model of coping which included the following subscales: Problem Solving, Mindfulness, Maladaptive Coping, Social Support, and Avoidance. Overall, reliability of the ACI was excellent and the internal consistency of the factors ranged from adequate to excellent. Evidence of convergent, concurrent, and incremental validity of the questionnaire was also established. Results provide initial support for the psychometric properties of the ACI.