Percentage points of Wilks'L mvc andL vc criteria

Likelihood ratio tests have been proposed by Wilks for testing the hypothesis of equal means, variances, and covariances (H _mvc) and the hypothesis of equal variances and covariances (H _vc) in ap-variate normal distribution. Using exact distributions of the appropriate likelihood ratio statistics, tables of the .05 and .01 points of these distributions are constructed forp = 4, 5, 6, 7 and sample sizen = 25 (5) 60 (10) 100. A correction factor is recommended for largern. Two numerical examples illustrate use of the tables. A nonparametric test is proposed forH _mvc when the multivariate parent population is known to be non-normal.This research was supported partly by the Office of Naval Research under Contract No. Nonr-855(06) and partly by the United States Air Force through the Air Force Office of Scientific Research of the Air Research and Development Command, under Contract No. 18(600)-83. Reproduction in whole or in part for any purpose of the United States Government is permitted.     

Projector slide changing and focusing as operant reinforcers

Uninstructed subjects choose to view, in sharp focus where possible, projected visual images in preference to various simpler auditory and visual stimuli (e.g., buzzers of flashing lights). The rate of responding on the lever rapidly increased above the operant level (projector inoperative) even though the stimuli were nonsense syllables. When focusing also was made contingent on responses, the subjects promptly started sharpening the focus of legible but blurred nonsense syllables. When the visual material was colored landscape scenes, the rates of slide-changing generally decreased, because of increased viewing time relative to the nonsense syllables, at the same time that the latencies of focusing decreased. Both the sharpness of focus and the total time spent with the image in sharp focus increased greatly with the colored slides, establishing that the subjects were under control of the stimulus events. Extinction of both responses occurred very rapidly when the controls became inoperative.     

《剑桥医学史》序言

在西方 ,人们从来没有像今天这样健康、长寿 ,医学的成就也从来没有像今天这样巨大。然而 ,具有讽刺意味的是 ,人们也从来没有像今天这样强烈地对医学产生疑惑和提出批评。毋庸置疑 ,在过去5 0年里医学突破性的进展 ,已挽救了比以往任何时代都要多得多的生命。我们已开始厌倦医学的进步 ,以至于应当对今天认为是当然 ,而一二百年前是不可能的巨大变革进行观察。以下章节将要讨论这些进步。作为导言 ,在这里简要地概括一下在 2 0世纪下半叶发生的重大变化。二战爆发时 ,青霉素仍在实验室研究阶段 ,尚未投入临床应用。在这种抗生素“魔弹”发…     

Accidental germ-line modifications through somatic cell gene therapies: some ethical considerations

Proposed somatic cell gene-therapies (especially those involving in utero therapies) may involve a small risk of germ-line modifications; this risk has engendered serious concern, and arguments have been made that such therapies ought not be pursued if such risks exists. We argue here that while pursuing deliberate germ-line modifications in humans would be inappropriate given the current state of the art, the risk of accidental germ-line modifications from most currently proposed in utero gene therapy is no different in kind or degree from other risks regularly taken in medical procedures. Given the possible benefits of such therapies, we argue that the risk of accidental germ-line modifications is well worth taking in these cases.     

The accuracy of reaching movements in brief delay conditions.

We tested the hypothesis that a highly accurate target representation is available to the visuomotor system in brief (< 2 s) delay conditions. Participants reached to single midsagittal targets (20, 25, 30, 35, 40 cm amplitude) in full vision, open-loop and delay conditions (500, 1,000, 1,500 or 2,000 ms). Radial endpoint error was significantly greater for open-loop than full vision reaches, and was greater still for all delay conditions, which did not differ from one another. Radial error was greater for farther targets, although this tended to hold only for delayed reaches. These data suggest that the visuomotor system switches from on-line visual information to a degraded, stored representation very soon (< 500 ms) if not immediately after target occlusion.     

Ethnicity and Gender Stereotypes of Emotion

In three studies we investigated gender stereotypes of emotions among four ethnic groups in the U.S., using persons from these groups as informants about their own groups. European Americans’ reports of stereotypes were compared to those of African Americans (Study 1), Hispanic Americans (Study 2), and Asian Americans (Study 3). The examination of group differences was interpreted based on variations across ethnicities in norms concerning emotional expression and gender roles. Overall, gender stereotypes of emotion were evident among all ethnic groups studied, but European Americans’ gender stereotypes were the most gender differentiated. For example, European American stereotypes held that men express more pride than women do, but African Americans’ stereotypes of pride for men and women did not differ. Similarly, whereas among European Americans, women were stereotyped to express much more love than men do, the gender difference was smaller among Hispanic Americans and Asian Americans. These different norms may pose challenges for inter-cultural interactions, and they point to the importance of considering both gender and ethnicity simultaneously in the study of emotions.     

Simulation and virtual reality in medical education and therapy: a protocol.

Continuing medical education has historically been provided primarily by didactic lectures, though adult learners prefer experiential or self-directed learning. Young physicians have extensive experience with computer-based or "video" games, priming them for medical education--and treating their patients--via new technologies. We report our use of standardized patients (SPs) to educate physicians on the diagnosis and treatment of biological and chemical warfare agent exposure. We trained professional actors to serve as SPs representing exposure to biological agents such as anthrax and smallpox. We rotated workshop participants through teaching stations to interview, examine, diagnose and treat SPs. We also trained SPs to simulate a chemical mass casualty (MASCAL) incident. Workshop participants worked together to treat MASCAL victims, followed by discussion of key teaching points. More recently, we developed computer-based simulation (CBS) modules of patients exposed to biological agents. We compare the strengths and weaknesses of CBS vs. live SPs. Finally, we detail plans for a randomized controlled trial to assess the efficacy of virtual reality (VR) exposure therapy compared to pharmacotherapy for post-traumatic stress disorder (PTSD). PTSD is associated with significant disability and healthcare costs, which may be ameliorated by the identification of more effective therapy.     

Alone but feeling no pain: Effects of social exclusion on physical pain tolerance and pain threshold, affective forecasting, and interpersonal empathy

Prior findings of emotional numbness (rather than distress) among socially excluded persons led the authors to investigate whether exclusion causes a far-reaching insensitivity to both physical and emotional pain. Experiments 1-4 showed that receiving an ostensibly diagnostic forecast of a lonesome future life reduced sensitivity to physical pain, as indicated by both (higher) thresholds and tolerance. Exclusion also caused emotional insensitivity, as indicated by reductions in affective forecasting of joy or woe over a future football outcome (Experiment 3), as well as lesser empathizing with another person's suffering from either romantic breakup (Experiment 4) or a broken leg (Experiment 5). The insensitivities to pain and emotion were highly intercorrelated.     

Basic processes in reading: can functional phonological recoding be blocked?

A widely held view is that phonological processing is always involved in lexical access from print, and is automatic in that it cannot be prevented. This claim was assessed in the context of a priming paradigm. In Experiment 1, repetition priming was observed for both pseudohomophone-word pairs (e.g., brane-brain) and morphologically related word pairs (e.g., marked-mark) in the context of lexical decision. In Experiment 2, subjects searched the prime for the presence of a target letter and then made a lexical decision to a subsequent letter string. Phonological priming from a pseudohomophone was eliminated following letter search of the prime, whereas morphological priming persisted. These results are inconsistent with the claim that a) lexical access from print requires preliminary phonological processing, and b) functional phonological processing cannot be blocked. They are, however, consistent with the conclusion that, for intact skilled readers, lexical access can be accomplished on the basis of orthographic processing alone. These results join a growing body of evidence supporting the claim that there exist numerous points in visual word recognition at which processing can be stopped.