干细胞移植治疗视网膜疾病的启示

干细胞是指具有自我更新、高度增殖和多向分化潜能的细胞群体,通过胚胎干细胞及视网膜干细胞、骨髓间充质细胞等成体干细胞移植治疗眼底病是近年来研究的热点,并取得了重要进展,为视网膜疾病的治疗开辟了新的途径,但同时也面临着技术的探讨及哲学的思考。本文就干细胞移植治疗视网膜疾病这一问题进行相关哲学思考。     

Locus of control, self-control, and family income as predictors of young children's mathematics and science scores

Locus of control, self-control, and family income were investigated as possible predictors of 138 young children's mathematics and science scores. The children, 60 boys and 78 girls, ranging from 4 to 8 years of age (M = 5.4, SD = 1.3) were administered the Stephens-Delys Reinforcement Contingency Interview Scale, the Self-control Rating Scale, the Comprehensive Mathematics Inventory, and a science test based on the work of D. K. Dickinson. Analysis showed mathematics scores were positively related to income, locus of control, and science scores. Mathematics and science scores were negatively related to lack of self-control. Also, science scores were positively related to locus of control. Multiple regression analysis with mathematics as the dependent variable indicated income had the greatest predictive value followed by self-control and locus of control. The multiple regression model of science was also significant, with locus of control having the greatest influence followed by self-control.     

胎儿产前超声诊断中的人文关怀

随着医学的进步,医学模式的转变,越来越提倡医学对人们心理和社会因素的关怀。同时随着产前诊断技术和超声诊断技术的迅速发展和日臻完善,以及社会、经济的发展和变革,也越来越重视对孕妇及家属的人文关怀。胎儿产前超声诊断中的人文关怀不仅是对人的关怀,也是对技术、对心理健康、对生命的关怀。     

高等医学院校医事法学教育亟待加强

通过千余份问卷调查研究,透视出医学生对医事法律认知程度普遍偏低的状况,进而从医学院教育方针,以及医学生法律意识、自我教育能力等方面,分析、探究原因,寻求改进医事法学教育滞后问题,加速培养学医懂法医学人才的途径与方法。     

ART伦理督导的实践与评价

在生殖中心(医院)中,将伦理原则的学习与技术规范的掌握相结合,将伦理学评价与员工的奖惩机制相结合,将伦理学研究与管理骨干的培养相结合,将伦理原则的贯彻与工作总结相结合;发挥医学伦理委员会监督的权威作用,重视群众监督手段的督促作用,借助国家行政督导机构和行业法规的震慑作用,是ART增强道德约束能力的有效机制。     

ART伦理督导的实践与评价

在生殖中心(医院)中,将伦理原则的学习与技术规范的掌握相结合,将伦理学评价与员工的奖惩机制相结合,将伦理学研究与管理骨干的培养相结合,将伦理原则的贯彻与工作总结相结合;发挥医学伦理委员会监督的权威作用,重视群众监督手段的督促作用,借助国家行政督导机构和行业法规的震慑作用,是ART增强道德约束能力的有效机制.     

ART知情同意的困境与对策

由于受到千百年来传统家庭观念及患者认知能力的影响,同时,由于辅助生殖技术(ART)的专业性、复杂性,ART技术应用的局限性、结果的不确定性以及诊治周期长、费用高等因素的存在,ART知情同意过程面临着困境.ART伦理管理落实真实知情同意的体现在对患者进行充分、全面、如实的信息告知,取得其配偶的同意和支持,完善的、个案化的文书签定,是ART伦理管理落实真实知情同意的体现.     

墨西哥医疗保障体系改革及其对我国的借鉴

墨西哥近年的医疗卫生改革取得了巨大的成就.通过简要地描述墨西哥人群健康状况、医疗卫生资源现状、卫生系统绩效以及与中国的比较,分析了墨西哥三轮卫生改革的特点、存在的问题以及面临的挑战,旨在提出墨西哥卫生系统与医疗保障体系改革对我国医疗卫生改革的启示和借鉴.     

解题反思对数学学业优差生解题过程的影响

考察解题反思对数学学业优生和差生解题结果及所用策略的不同影响。选取初一至初三年级的数学学业优生和差生为被试,以一套连加数问题为实验材料,进行一对一的测试,前后进行两次测试。对反思组优差生(优生12人,差生10人)和无反思组优差生(优生14人,差生14人)解题过程的比较,发现:1)解题后立即进行反思能够提高差生的解题正确率,但是延长解题时间;2)先前的解题反思对优生和差生后续解题时的正确率和解题时间均不产生明显影响;3)解题后立即进行反思能够促进优生和差生使用高效策略,放弃低效策略;4)先前的解题反思在后续解题中仍然促进学生使用高效策略,对优生的促进作用比对差生更明显。     

Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor

Since the brain neurotransmitter changes characterising panic disorder remain uncertain, we quantified brain noradrenaline and serotonin turnover in patients with panic disorder, in the absence of a panic attack. Thirty-four untreated patients with panic disorder and 24 matched healthy volunteers were studied. A novel method utilising internal jugular venous sampling, with thermodilution measurement of jugular blood flow, was used to directly quantify brain monoamine turnover, by measuring the overflow of noradrenaline and serotonin metabolites from the brain. Radiographic depiction of brain venous sinuses allowed differential venous sampling from cortical and subcortical regions. The relation of brain serotonin turnover to serotonin transporter genotype and panic disorder severity were evaluated, and the influence of an SSRI drug, citalopram, on serotonin turnover investigated. Brain noradrenaline turnover in panic disorder patients was similar to that in healthy subjects. In contrast, brain serotonin turnover, estimated from jugular venous overflow of the metabolite, 5-hydroxyindole acetic acid, was increased approximately 4-fold in subcortical brain regions and in the cerebral cortex (P < 0.01). Serotonin turnover was highest in patients with the most severe disease, was unrelated to serotonin transporter genotype, and was reduced by citalopram (P < 0.01). Normal brain noradrenaline turnover in panic disorder patients argues against primary importance of the locus coeruleus in this condition. The marked increase in serotonin turnover, in the absence of a panic attack, possibly represents an important underlying neurotransmitter substrate for the disorder, although this point remains uncertain. Support for this interpretation comes from the direct relationship which existed between serotonin turnover and illness severity, and the finding that SSRI administration reduced serotonin turnover. Serotonin transporter genotyping suggested that increased whole brain serotonin turnover most likely derived not from impaired serotonin reuptake, but from increased firing in serotonergic midbrain raphe neurons projecting to both subcortical brain regions and the cerebral cortex.