Hippocampal injections of amyloid beta-peptide 1-40 impair subsequent one-trial/day reward learning

The injection of amyloid beta-peptide (Abeta) into rat CNS has been reported to induce cellular neuropathology. The present study investigated whether multiple intrahippocampal injections of Abeta 1-40 would impair one-trial/day reward learning 14 days later. Twenty-four male Sprague-Dawley rats, 3-4 months old, were injected with either Abeta 1-40 or distilled water into seven hippocampal sites bilaterally. Ten rats received 3 nmol Abeta 1-40 in 2 microl of distilled water per injection site, while 14 rats received distilled water alone. Following a 9-day recovery period, rats were gradually food deprived to 82% of their initial body weight. Fourteen days after the intrahippocampal injection, all rats received an initial training trial and three subsequent daily retention trials. Rats receiving Abeta 1-40 were significantly impaired on the second retention trial in terms of accuracy (number of unbaited alleys entered) and on the second and third retention trials in terms of speed (reciprocal of latency to reward). Histological analysis showed that Abeta 1-40 injections produced significant neuronal loss and gliosis. Abeta 1-40 immunoreactivity persisted locally at the injection site and in macrophages 2 weeks following the hippocampal injections. These effects appear to be sequence-specific; rats receiving Abeta 1-42 with a scrambled peptide sequence did not differ significantly from rats receiving distilled water alone in retention of the learning task or degree of histological damage.     

The Affective Temperaments and Well-Being: Swedish and Iranian Adolescents’ Life Satisfaction and Psychological Well-Being

The aim was to investigate the role of the affective temperament model (AFTs) in distinguishing variations in well-being among adolescents from Sweden (n = 222) and Iran (n = 120). Participants self-reported positive (PA) and negative affect (NA), life satisfaction (LS) and psychological well-being (PWB). The model categorizes participants in four different temperaments using the Positive Affect and Negative Affect Schedule (PANAS): self-actualizing (high PA and low NA), high affective (high PA and high NA), low affective (low PA and low NA), and self-destructive (low PA and high NA). Across cultures, self-actualizing adolescents reported higher LS and PWB. The PWB sub-scale of self-acceptance was positively related to LS regardless of temperament profile or cultural background. Nevertheless, Iranian adolescents with self-destructive profiles reported higher LS than high affective Iranians. The AFTs model is suggested to offer something unique by taking into account the interaction of PA and NA.     

Crowded minds: the implicit bystander effect

Five studies merged the priming methodology with the bystander apathy literature and demonstrate how merely priming a social context at Time 1 leads to less helping behavior on a subsequent, completely unrelated task at Time 2. In Study 1, participants who imagined being with a group at Time 1 pledged significantly fewer dollars on a charity-giving measure at Time 2 than did those who imagined being alone with one other person. Studies 2-5 build converging evidence with hypothetical and real helping behavior measures and demonstrate that participants who imagine the presence of others show facilitation to words associated with unaccountable on a lexical decision task. Implications for social group research and the priming methodology are discussed.     

Infection markers and early signs of neonatal encephalopathy in the term infant

Recent evidence points to an association between intrauterine infection and cerebral palsy (CP) in the preterm as well as the term infant. The mechanisms that link these two conditions are unclear. Chorioamnionitis is a common clinical problem complicating 5-10% of pregnancies, whereas the incidence of CP attributed to intrapartum asphyxia is rare. Chorioamnionitis may result in brain injury as a result of interruption of placental blood flow (asphyxia), or via fever and/ or the cytokine release associated with infection. This review will attempt to establish the link between perinatal infection and brain damage in term infants. The characteristics of the perinatal inflammatory response, the potential mechanisms of brain injury associated with infection, and the clinical characteristics of neonatal encephalopathy will be discussed.     

The Greek ID Card Controversy: A Case Study of Religion and National Identity in a Changing European Union

This article presents the initial findings of a research project funded by the Leverhulme Trust from 2003 to 2005. It should be seen as the sequel to a pilot study originally conducted in 2002 and published in the Journal of Contemporary Religion in 2003 (Molokotos-Liederman, ”Identity Crisis“). The article examines the ID card controversy in Greece, setting it in its broader European context. Using data from newspaper articles and interviews, it maps the different opinion groups that emerge from this controversy and offers a preliminary analysis of these views. The final section indicates a range of topics that are emerging from this study and merit further investigation.     

Estimated age of acquisition norms for 834 Portuguese nouns and their relation with other psycholinguistic variables

The main objective of this study is to report rated age of acquisition (AoA) norms for 834 nouns in Portuguese (European). AoA ratings were collected on a 7 point scale, generally following Gilhooly and Logie (1980) procedure with an 8 extra point for "don't know the word" answers. Results were analyzed considering AoA ratings and their standard deviations and considering the relationship between AoA ratings and other psycholinguistic variables (imageability, familiarity, written word frequency, concreteness, number of syllables and number of words). AoA ratings and their standard deviations were significantly and positively correlated, with early acquired word ratings showing higher agreement. Correlation and multiple regression analyses confirmed the major contribution of imageability and familiarity to AoA ratings obtained in other languages. The full database of AoA ratings and other psycholinguistic variables may be downloaded from www.psychonomic.org/archive or www.fpce.ul.pt/pessoal/ulfpfred/aoa.htm.     

Telephone versus print delivery of an individualized motivationally tailored physical activity intervention: Project STRIDE.

OBJECTIVE: Given that only 25% of Americans meet physical activity recommendations, there is a need to develop and disseminate effective, evidence-based interventions to promote physical activity. The authors tested 2 delivery channels, telephone and print, to determine whether one was more effective in promoting physical activity. DESIGN: The authors randomly assigned 239 healthy, sedentary adults to (a) telephone-based individualized feedback, (b) print-based individualized feedback, or (c) contact control. Both intervention arms were guided by a motivationally tailored, theoretically driven computer expert system. MAIN OUTCOME MEASURES: Physical activity as measured by the 7-day Physical Activity Recall interview. RESULTS: At 6 months, both telephone and print arms significantly increased in minutes of moderate intensity physical activity compared with control, with no differences between the intervention arms. At 12 months, print participants reported a significantly greater number of moderate intensity minutes than both telephone and control participants, who did not differ. CONCLUSION: Results suggest that both telephone and print enhance the adoption of physical activity among sedentary adults; however, print interventions may be particularly effective in maintaining physical activity in the longer term.     

The role of career adaptability in predicting entrepreneurial intentions: A moderated mediation model

Guided by the Career Construction Theory (Savickas, 2013), we view entrepreneurship as an adaptive vocational behavior driven by an individual's self-regulatory capacity to thrive in a complex entrepreneurial career context. Our research model posited that individuals rely on their adaptive resources and entrepreneurial self-efficacy as they form entrepreneurial intentions. Career adaptability, as self-regulatory competencies, is further strengthened by prior exposure to family business. We collected data over three measurement periods from Serbian business students (n = 380) and validated the Career Adapt-Abilities Scale (CAAS). The moderated mediation model was supported and as predicted: (a) career adaptability was positively associated with entrepreneurial intentions and (b) the mediated relationship between career adaptability and entrepreneurial intentions via entrepreneurial self-efficacy was stronger for individuals with prior exposure to family business. In addition, we provide evidence for the psychometric properties of CAAS by examining its internal consistency, test–retest reliability, and factor structure. Taken together, our study offers the groundwork for understanding successful adaptation in the entrepreneurial career context and supports the cross-national measurement equivalence and utility of CAAS in a developing economy.