Conditioning in human opiate addicts

Eight volunteers maintained on daily methadone participated in a classical conditioning procedure to determine which if any of the elements of narcotic withdrawal could be conditioned. The unconditioned stimulus was the injection of a small dose of naloxone. The unconditioned response was a brief precipitated withdrawal syndrome. The conditioning stimulus was a tone, odor, and injection of saline. Conditioning was successful in the pilot study in 5 of 8 subjects. The conditioned response consisted of tearing, yawning, lacrimation, systolic blood pressure increase, respiratory irregularities and subjective feelings of narcotic withdrawal sickness (nausea, muscle aches, chills). A second group of 8 subjects showed, in addition to the above, evidence of conditioning of heart rate, respiratory rate and skin temperature decrease. These laboratory findings support the clinical reports of a conditioned withdrawal syndrome and suggest ways to improve treatment results by detecting and extinguishing or modifying conditioned responses.     

Stimulus probability and same-different classification

Three experiments investigated the effect of stimulus probability on same-different classification time. In Experiments I and II, subjects made same responses on the basis of name matches of simultaneously presented letters. Half of the same trials involved letters that were also physically identical. Experiment I showed that the presentation probability of specific letters affected name matches and different responses, but not physical matches. Experiment II varied stimulus contrast as well as probability. Contrast had a main effect but did not interact with probability at any level of processing. In Experiment III, subjects were switched to the physical level of processing. Stimuli that now had the same name but differed in case were called different. In this condition, the probability effects obs(irved in Experiment II disappeared. These results are interpreted as demonstrating that stimulus probability has its effect during the process that derives the name of the stimulus from the visual representation. This process takes place before the name comparison is made, and the name comparison process precedes the determination of the different response.     

Correlations of normality and nervousness with cardiovascular functions in pointer dogs

Methylphenidate, 0.5 mg/kg, injected intravenously, was used in 10 normal (A line) and 10 genetically nervous (E line) dogs in a blind-design experiment to aid in prediction, from cardiovascular recordings alone, of behavioral normalityversus nervousness. The prediction was 75 per cent correct, based on heart rate (HR), form of the electrocardiogram (EKG), pattern of sinus arrhythmia, and pattern of HR response to methylphenidate. Nervous dogs were found to have slower baseline HR’s, delayed return of HR to baseline after methylphenidate, greater occurrence of baseline EKG abnormalities and much greater frequency of these after methylphenidate. Degree of nervousness was found to correlate rather highly (1)negatively with baseline HR level, (2)negatively with speed of BP response, and (3)positively with frequency of some of the EKG manifestations. These data, indicative of a relative inertness of physiological functions of nervous pointer dogs compared with normal pointers, are consistent with the behavioral and some of the biochemical findings previously reported.     

A color aftereffect contingent on complex pattern features

It was shown that a McCollough-type color aftereffect could be induced using a pair of patterns each of which contained lines of many orientations (radial lines and concentric circles). That is, the two patterns appear to be color adapted independently. The effect could simply be a new version of the McCollough effect facilitated by a tendency to fixate the centers of the patterns. Also, the size features of the displays could be used as the basis of a spatial frequency analyzer explanation. Experimental data were used to test both of these suggestions, but very little support was found for either. It was therefore suggested that the major basis of the effect was the color adaptation of “curvature analyzers.”