Systematicity and the Continuity Thesis

Synthese - Hoyningen-Huene (Systematicity: the nature of science, Oxford University Press, Oxford, 2013) develops an account of what science is, distinguishing it from common sense. According to...     

TWO STRAINS IN BUDDHIST CAUSALITY

This essay will focus on the Buddhist metaphysics of experience which is generally glossed over due to the excessive concern for the ultimate goal in Buddhism, nirvīna , and in consequence of which the emphasis has been on the practice of; meditative discipline in aspiration for that goal. Yet neither nirvana nor meditative discipline can be understood properly without examining the full dimension of our ordinary experience. Such an examination should reveal to us the unique ways in which the Buddhist refers to the bounded and unbounded conditions of existence. All this is novel insofar as metaphysics goes and indeed it would have to be a unique form of metaphysics in order to accommodate the dual aspect of existence. The key to this metaphysics lodges in the Buddhist concept of experiential process,¹ technically known as pratītyasamutpāda which is variously translated as relational origination, interrelational origination or dependent origination. It refers to the Buddhist concept of causality but, as we shall see, it is a unique concept with more than the usual Western connotation.     

Persistent alterations in biological profiles in women with abuse histories: influence of premenstrual dysphoric disorder.

OBJECTIVE: To examine dysregulation in biological measures associated with histories of abuse in women and whether women with premenstrual dysphoric disorder (PMDD) differ in their dysregulation. DESIGN: Twenty-five women meeting prospective criteria for PMDD and 42 non-PMDD controls underwent structured interview to determine abuse histories and lifetime Axis I diagnoses, excluding those with current Axis I disorders or using medications. MAJOR OUTCOME MEASURES: Plasma cortisol and norepinephrine (NE), heart rate (HR), blood pressure (BP), and vascular resistance index (VRI) were assessed at rest and in response to mental stress. RESULTS: A greater proportion of PMDD women had prior abuse compared with non-PMDD women. Regardless of PMDD status, all abused women had lower plasma NE and higher HRs and tended to have lower plasma cortisol at rest and during stress. Abused women also reported more severe daily emotional and physical symptoms. Greater VRI and BP at rest and during stress were seen only in PMDD women with abuse. CONCLUSION: There is persistent dysregulation in stress-responsive systems in all abused women that cannot be accounted for by current psychiatric illness or medications, and PMDD women may be differentially more vulnerable to the impact of abuse on measures reflecting alpha-adrenergic receptor function.