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排序方式: 共有166条查询结果,搜索用时 15 毫秒
21.
Liu YF Chen HI Yu L Kuo YM Wu FS Chuang JI Liao PC Jen CJ 《Neurobiology of learning and memory》2008,90(1):81-89
Cognitive functions usually involve various synaptic proteins and neurotrophic factors in the hippocampus. However, whether treadmill exercise can improve learning and memory by upregulating some of these molecules remain unraveled. To address this question, male BALB/c mice were divided into control and exercise groups, the latter group went through 4 weeks of treadmill exercise training. At the end of exercise training period, they were either tested for passive avoidance (PA) performance or sacrificed for quantifying the hippocampal levels of brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB, the BDNF receptor), synaptotagmin (a Ca2+-dependent synaptic vesicle protein), and SNAP-25 (a presynaptic vesicular fusion protein). Our results showed that treadmill exercise training (1) increased the retention latency without affecting the fear acquisition in the PA test, (2) transiently increased the hippocampal BDNF level at 1, 2, and 4 h after the completion of exercise training, and (3) persistently increased the hippocampal protein levels of full-length TrkB, phosphorylated TrkB and synaptotagmin, but not truncated TrkB or SNAP-25. Moreover, the protein expression level of full-length TrkB or synaptotagmin was positively correlated with PA performance in mice. Finally, inhibition of TrkB signaling by K252a abolished the exercise-facilitated PA performance and upregulation of TrkB and synaptotagmin. Taken together, these data suggest that the upregulation of TrkB and synaptotagmin in the hippocampus contributes to the exercise-facilitated aversive memory. 相似文献
22.
This study investigated the concurrent validity of the Comprehensive Developmental Inventory for Infants and Toddlers (CDIIT) with the Bayley Scales of Infant Development-II (BSID-II) in full-term infants. 106 full-term infants ages 6 to 18 months (63 boys, 43 girls) were recruited as a convenience sample. One tester administered the CDIIT and BSID-II to all children. The Developmental Ages and Developmental Quotients of the motor and the mental scales from both tests were analyzed with Pearson correlations and quadratic weighted kappa tests. The results showed that correlation coefficients for Developmental Ages between both tests on cognitive and motor subtests were high (r = .91-.95) and for Developmental Quotients were moderate (r = .57-.67). Moderate classification agreement was found in the two scales (quadratic weighted kappa = .50-.53). Developmental Quotients classification for the CDIIT tended to be a little higher than for the BSID-II. It was concluded that although acceptable concurrent validity was found for the Motor and Cognitive subtests of the CDIIT, the tester should be cautious to compare Developmental Quotients obtained from the above two tests in clinical or in research settings. 相似文献
23.
24.
Kuo YM Liang KC Chen HH Cherng CG Lee HT Lin Y Huang AM Liao RM Yu L 《Neurobiology of learning and memory》2007,87(1):93-100
Context-induced drug craving and continuous drug use manifest the critical roles of specific memory episodes associated with the drug use experiences. Drug-induced conditioned place preference (CPP) in C57BL/6J mouse model, in this regard, is an appropriate behavioral paradigm to study such drug use-associated memories. Requirement of protein synthesis in various forms of long-term memory formation and storage has been phylogenetically demonstrated. This study was undertaken to study the requirement of protein synthesis in the learning and memory aspect of the conditioned place preference induced by cocaine and methamphetamine, two abused drugs of choice in local area. Since pCREB has been documented as a candidate substrate for mediating the drug-induced neuroadaptation, the pCREB level in hippocampus, nucleus accumbens, and prefrontal cortex was examined for its potential participation in the formation of CPP caused by these psychostimulants. We found that cocaine (2.5 and 5.0 mg/kg/dose)-induced CPP was abolished by the pretreatment of anisomycin (50 mg/kg/dose), a protein synthesis inhibitor, whereas methamphetamine (0.5 or 1.0 mg/kg/dose)-induced CPP was not affected by the anisomycin pretreatment. Likewise, cocaine-induced CPP was mitigated by another protein synthesis inhibitor, cycloheximide (15 mg/kg/injection) pretreatment, whereas methamphetamine-induced CPP remained intact by such pretreatment. Moreover, anisomycin treatment 2h after each drug-place pairing disrupted the cocaine-induced CPP, whereas the same treatment did not affect methamphetamine-induced CPP. An increase of accumbal pCREB level was found to associate with the learning phase of cocaine, but not with the learning phase of methamphetamine. We further found that intraaccumbal CREB antisense oligodeoxynucleotide infusion diminished cocaine-induced CPP, whereas did not affect the methamphetamine-induced CPP. Taken together, these data suggest that protein synthesis and accumbal CREB phosphorylation are essential for the learning and consolidation of the cocaine-induced CPP, whereas methamphetamine-induced CPP may be unrelated to the synthesis of new proteins. 相似文献
25.
廖申白 《Frontiers of Philosophy in China》2009,4(2):251-263
The concept of right or fit is an important element entailed, but not fully articulated, in the concept of action or practice in Aristotle’s theory of virtue; which, however, turns to be of the utmost importance in later Western ethics. Right is concerned with both feelings and actions, and is not the same for all individuals. It lies in between the two extremes of the spectrum of practical affairs, yet by no means equidistant from them. This account of the concept of fitness or right is derived from the categories of quantity, relationship, and quality rather than from that of substance. Thus, it seems that virtue is relative to vice or error within a continuous existence. If, however, the right of passion and action is environmental and concrete, is it multiple and not singular? To this question, Aristotle gives his reply on two levels: On the level of concrete practitioners, what is right and fit to one man might not be so to another man, and hence the right of practice is not singular but multiple; whereas on the level concerned with the only right choice compared with the two extremes or errors, the right of practice will always be singular. 相似文献
26.
S. Matthew Liao 《Philosophical Studies》2009,146(2):223-231
Judith Jarvis Thomson’s Loop Case is particularly significant in normative ethics because it questions the validity of the
intuitively plausible Doctrine of Double Effect, according to which there is a significant difference between harm that is
intended and harm that is merely foreseen and not intended. Recently, Frances Kamm has argued that what she calls the Doctrine
of Triple Effect (DTE), which draws a distinction between acting because-of and acting in-order-to, can account for our judgment
about the Loop Case. In this paper, I first argue that even if the distinction drawn by DTE can be sustained, it does not
seem to apply to the Loop Case. Moreover, I question whether this distinction has any normative significance. The upshot is
that I am skeptical that DTE can explain our judgment about the Loop Case. 相似文献
27.
我国中小学生心理健康服务从业人员及工作状况调查 总被引:1,自引:0,他引:1
该研究的目的是考察我国中小学生心理健康服务从业人员及专业工作的基本情况,并比较其地区差异,分析存在的问题。调查包括来自重庆、甘肃、辽宁、福建、湖北以及西藏等6个省市自治区的596名被试。研究采用自编问卷调查中小学生心理健康从业队伍情况及其专业工作情况。结果发现各地区之间发展确实存在不均衡的状况,辽宁、福建等东部发达地区从业人员专业化水平相对较高;西藏、甘肃等地区则相对较为落后,特别体现在人员结构不合理、职称待遇偏低、缺少专业培训等方面。 相似文献
28.
Christine Walrath Susan dosReis Richard Miech Qinghong Liao E. Wayne Holden Gary De Carolis Rolando Santiago Philip Leaf 《Journal of child and family studies》2001,10(3):385-397
We report one of the first multi-site investigations into referral source variation in functional impairment for children with serious emotional disturbance served in systems of care settings. Baseline data collected as part of the national evaluation for the Comprehensive Community Mental Health Services for Children and Their Families Program was used to assess the comparability of functional status for children referred from traditional mental health versus non-mental health agencies. Results indicate that children referred from child welfare and family groups have significantly lower levels of overall dysfunction than those referred from mental health, while children referred from school and juvenile justice agencies have comparable levels. Clinical and research implications are discussed. 相似文献
29.
尊重——公共生活的基础性道德价值 总被引:1,自引:0,他引:1
尊重是公共生活中基础性的道德价值诉求.康德伦理学揭示出了属于现代公共生活的尊重类型,它不仅与私域生活中以情感为基础的尊重有区别,更与传统社会的等级性尊重不一样.尊重作为公共生活的道德价值,既需要通过制度的安排去实现,又要在人们平等的相互对待行为中体现出来. 相似文献
30.
The fusion of two amplitude-modulated (AM) tones presented simultaneously was studied. Subjects were presented with an AM tone (A) followed by a copy of itself (B) which was accompanied by another AM tone (C). In different experiments, the subjects were asked either to rate how clearly they could hear Tone B in the BC mixture or whether Tone B was present or not. The stronger the fusion of Tones B and C, the harder it was to "hear out" Tone B. It was found that fusion was strongest when Tones B and C were modulated at the same rate; segregation curves were obtained for the degree of mismatch of modulation frequency. 相似文献