Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress

Prenatal stress can cause long-term effects on cognitive functions in offspring. Hippocampal synaptic plasticity, believed to be the mechanism underlying certain types of learning and memory, and known to be sensitive to behavioral stress, can be changed by prenatal stress. Whether enriched environment treatment (EE) in early postnatal periods can cause a recovery from these deficits is unknown. Experimental animals were Wistar rats. Prenatal stress was evoked by 10 foot shocks (0.8 mA for 1s, 2-3 min apart) in 30 min per day at gestational day 13-19. After weaning at postnatal day 22, experimental offspring were given the enriched environment treatment through all experiments until tested (older than 52 days age). Electrophysiological and Morris water maze testing was performed at 8 weeks of age. The results showed that prenatal stress impaired long-term potentiation (LTP) but facilitated long-term depression (LTD) in the hippocampal CA1 region in the slices. Furthermore, prenatal stress exacerbated the effects of acute stress on hippocampal LTP and LTD, and also impaired spatial learning and memory in the Morris water maze. However, all these deficits induced by prenatal stress were recovered by enriched environment treatment. This work observes a phenomenon that may contribute to the understanding of clinically important interactions among cognitive deficit, prenatal stress and enriched environment treatment. Enriched environment treatment on early postnatal periods may be one potentially important target for therapeutic interventions in preventing the prenatal stress-induced cognitive disorders.     

学校组织气氛对教师工作倦怠的影响

问卷调查了410名北京市中学教师,探讨了学校组织气氛对教师工作倦怠的影响。结果发现:教师的工作倦怠没有性别、是否班主任、年龄、任课班级数量、学生人数、周任课时数上的差别。在职称和婚姻因素上有明显的差别,玩世不恭维度上,高级职称的教师工作倦怠明显高于中教一级和中教二级教师,中教一级和中教二级教师之间的工作倦怠没有显著差异,单身教师的情绪衰竭和成就感低落比己婚教师明显偏高。在控制了人口统计学变量之后,分层回归和优势分析发现:支持行为和限制行为能显著预测情绪衰竭,限制行为的贡献更大;支持行为、监督行为、限制行为和同事行为能显著预测玩世不恭,支持行为的贡献更大;支持行为、同事行为和疏远行为能显著预测成就感低落,同事行为的贡献更大;亲密行为对情绪衰竭、玩世不恭和成就感低落没有预测作用。     

攀缘激活的计时机制

攀缘激活指神经元在两个先后出现事件的间隔阶段呈现出的一种缓慢爬升式“期待”激活。这种激活的强度在后一事件出现时达最高峰,以致被视为一种可能时距编码机制而成为目前时间生物学研究的一个热点问题。目前攀援激活的计时作用神经机制有三种主要观点：膜电流假说、双稳态单元假说、线性整合假说。未来研究将主要集中于探索攀缘激活的神经元突触机制,非固定间隔时距条件下攀缘激活的计时机制及攀缘激活、运动准备和脉冲累加之间的关系。     

以人为本与科学无神论的家教发展观

一、“以人为本”的宗教观与“以神为本”的宗教观从宗教发展的历史来看,在欧洲, “神”与“人”的对立是自文艺复兴开始凸显出来的。在中世纪,有神论的宗教观,确切地说,使基督教的宗教观的独占统治达到了顶点,不仅其他社会意识形式如哲学、道德、文学艺术和科学成了它的婢女和仆人,而且人也成了神的创造物和奴仆。在宗教中,神或上帝是作为世界之“本”,即从本体论的意义上被确定为世界的“本原”的。因此,上帝被说成是具有创造一切的、至高无上的无限和绝对: 它创造了万物,又无处不在,无所不包;它威力无边,赏罚分明;它预知你的来生,又支配你的今     

妊娠期肝内胆汁淤积症研究中的因果论

妊娠期肝内胆汁淤积症是一种常见的妊娠晚期并发症,对围产儿的危害极大,其确切的病因及发病机制尚未十分清楚。只有了解了疾病的起因,才能更好地进行防治。凡病必有其因,以果推因,再取因治果,这是典型的因果论的应用。     

群际接触对外群体信任的影响:内群体认同的中介效应

目的:探讨内群体认同在群际接触对外群体信任的中介效应。方法:采用内群体认同量表、群际接触量表和外群体信任量表,对570名大学生进行测量,运用SPSS13.0、Amos22.0对数据进行统计分析。结果:内群体认同作为中介变量,群体接触通过内群体认同对外群体信任的具有稳定的间接作用。     

不同自我和谐水平青少年的认知加工偏向

为了探究不同自我和谐水平青少年的认知加工特点,44名被试先后进行自我相关词语的点-探测任务和词语的再认任务,结果发现:(1)高自我和谐水平的青少年对自我相关的积极词表现出注意优先,低自我和谐水平的青少年对自我相关的消极词表现出注意优先,但两者注意偏向无显著差异;(2)高自我和谐水平的青少年对自我相关的积极词的再认反应时显著短于低自我和谐水平青少年的,对积极词表现出了记忆偏向;低自我和谐水平的青少年对自我相关的消极词、中性词的再认反应时显著短于对积极词的反应时,对消极词、中性词表现出了记忆偏向。因此,不同自我和谐水平的青少年在认知加工的记忆阶段存在特质一致性。     

Stability of the Positive Mood Effect on Creativity When Task Switching,Practice Effect,and Test Item Differences are Taken into Consideration

Although experimentally induced positive mood can generally last for 20 min and the induced mood is conducive to creative performance, it is still unclear whether the facilitation effect is stable during these 20 min. Two studies were conducted to examine this issue while controlling for the impacts of task switching, practice effect, and test item differences. In Study 1, participants (N = 42) were randomly assigned to positive, negative, and neutral mood conditions. After watching a short video clip, participants answered four items of the Alternate Uses Test (AUT) in 20 min, with 5 min allotted for each item. Creative performance during each 5‐min period was scored in terms of fluency and flexibility. Separate repeated‐measures analyses of variances on these creativity scores showed that positive mood consistently enhanced performance over 20 min. Study 2 further eliminated the effects of test item differences and test order. Participants (N = 131) underwent the same mood induction procedure and answered the same four items of the AUT, except that these items were presented in four different sequences in accordance with the Latin square design. Consistent with the findings in Study 1, Study 2 showed that the facilitation effect of positive mood lasted for 20 min when the interference of task switching, practice effect, and test item differences were minimized. This finding not only sheds light on the debate regarding the stability of experimentally induced positive mood effect, but also contributes to the body of empirical evidence that future studies may use to examine the positive mood effect over a relatively long period of time.     

红色资源开发与社会主义核心价值体系教育

在新的形势下开发运用红色资源,充分挖掘和发挥红色资源的教育价值和育人功能,对于加强和创新社会主义核心价值体系教育具有十分重要的意义和独特的优势.当前,要创新红色资源开发运用的思路,并采取有效的实践策略加以实施,才能推动社会主义核心价值体系教育不断走向深入.     

复合运动刺激视觉追踪的初步研究

本实验采用多目标追踪和复合刺激研究范式,将注意追踪和知觉的整体优先性两个研究领域中存在的知觉组织规律相结合,对单一和多个复合刺激进行注意追踪研究.结果表明:在单一或多个复合刺激追踪过程中,同样遵循静态知觉组织原则;不同知觉组织形式对知觉加工有不同的影响,突出的颜色变化可以促进知觉组织加工.