豚尾猴(Macaca nemestrina)等灵长类动物反转学习的比较研究

不同种类猿猴脑高级机能的比较生理心理研究的资料很少,并且意见不完全一致。和(1997)曾报道黑猩猩较阿拉伯狒有较大的推断能力。Shell和Riopelle(1958)报道阔鼻猴蜘蛛猴(Ateles geoffroyi),卷尾猴(Cebus albifrons)     

睡眠剥夺时大鼠电休克阈值的变化

我们在研究睡眠剥夺影响大鼠记忆巩固的实验中,观察到睡眠剥夺引起大鼠条件反射的反应时(R T_(CR))明显缩短。我们认为,这可能反映了动物在睡眠剥夺后脑的兴奋性有所升高,本实验用电休克阈值作指标验证这一看法。     

Does awareness of speech as a sequence of phones arise spontaneously?

It was found that illiterate adults could neither delete nor add a phone at the beginning of a non-word; but these tasks were rather easily performed by people with similar environment and childhood experiences, who learned to read rudimentarily as adults. Awareness of speech as a sequence of phones is thus not attained spontaneously in the course of general cognitive growth, but demands some specific training, which, for most persons, is probably provided by learning to read in the alphabetic system.     

Conditioning of striatal dopamine metabolism with methadone,morphine or bulbocapnine as an unconditioned stimulus

Psychotropic drugs such as methadone, morphine and bulbocapnine produce increments in dopamine metabolism as an unconditioned reflex. When a buzzer noise is used as a conditioned stimulus (CS) with these drugs as unconditioned stimuli, the buzzer CS acquires the properties of the drugs in increasing dopamine metabolism. These results suggest that the brain, like other visceral organs, can be conditioned in terms of neurotransmitter release or metabolism.     

Acquired aphasia in children and the ontogenesis of hemispheric functional specialization.

We have described a series of 26 cases of cortical lesions in children from $\text{3}\text{1}\text{2}$ to 15 years of age (17 left-sided, six right-sided, three bilateral), in which 19 had varying degrees of language disturbance. We have attempted to establish the nature and evolution of these aphasic disorders, and have compared our observations to those previously published. Our analysis appears to indicate a relative hemispheric equipotentiality which permits the transfer of language representation to the opposite hemisphere in the case of a unilateral lesions in childhood. This conclusion, however, has at least the appearance of being in conflict with other reported findings, viz., those deriving from psychometric testing of subjects with unilateral perinatal lesions; and those concerning studies of fetal and newborn brains which suggest a very early, if not innate, hemispheric specialization.The fact of this discrepancy has lead us to reconsider the concept of a critical period as defined by Lenneberg. In this respect, we have also discussed the possibility of a partial transfer of language representation, of an intrahemispheric reorganization by intact “uncommitted” areas (P. Goldman), and finally, the need for an adequate stimulus during a given period in order for a preformed area to become functional.     

组织微阵列方法检测CD105、VEGF-C在肝癌组织中的表达

新生血管生成不仅为肿瘤组织提供营养支持,而且是肿瘤细胞进入循环系统的途径.CD105仅在激活的上皮细胞表达;VEGF-C为重要的血管生成因子之一,但二者与肝癌转移是否存在关联尚不明晰.探讨CD105及VEGF-C表达与肝癌肝内转移的关联.构建承载37例肝癌及癌旁组织的组织微阵列,免疫组织化学方法检测CD105及VEGF-C的表达.存在肝内转移的肝癌组织MVD-CD105均值为28.4±19.4,而无肝内转移的肝癌组织MVD-CD105均值为5.4±5.2,差异显著(P＜0.01);VEGF-C在存在肝内转移的肝癌组织表达率为46.15%(6/14),无肝内转移的肝癌组织中表达率为41.67%(10/24),二者无显著差异.MVD-CD105分值与肝癌肝内转移密切相关;血管生成可能在肝癌肝内转移过程中起重要作用.