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61.
The effects of early-onset blindness on the development of the visual system have been explained traditionally by the stabilization of transient connections through Hebbian competition. Although many of the findings from congenital cataract and congenital blindness are consistent with that view, there is inconsistent evidence from studies of visual cognition in children treated for visual deprivation from cataract, case reports of recovery of vision in adults, and studies of visual reorganization after late-onset blindness. Collectively, the data from congenital cataract and congenital blindness indicate that early visual experience sets up the infrastructure for later learning involving both the dorsal ("where") and ventral ("what") streams. Nevertheless, there is surprising residual plasticity in adulthood that can be revealed if vision is lost either temporarily or permanently. This has important implications for understanding the role of early visual experience in shaping visual cognitive development. 相似文献
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Environmental restriction or deprivation early in development can induce social, cognitive, affective, and motor abnormalities similar to those associated with autism. Conversely, rearing animals in larger, more complex environments results in enhanced brain structure and function, including increased brain weight, dendritic branching, neurogenesis, gene expression, and improved learning and memory. Moreover, in animal models of CNS insult (e.g., gene deletion), a more complex environment has attenuated or prevented the sequelae of the insult. Of relevance is the prevention of seizures and attenuation of their neuropathological sequelae as a consequence of exposure to a more complex environment. Relatively little attention, however, has been given to the issue of sensitive periods associated with such effects, the relative importance of social versus inanimate stimulation, or the unique contribution of exercise. Our studies have examined the effects of environmental complexity on the development of the restricted, repetitive behavior commonly observed in individuals with autism. In this model, a more complex environment substantially attenuates the development of the spontaneous and persistent stereotypies observed in deer mice reared in standard laboratory cages. Our findings support a sensitive period for such effects and suggest that early enrichment may have persistent neuroprotective effects after the animal is returned to a standard cage environment. Attenuation or prevention of repetitive behavior by environmental complexity was associated with increased neuronal metabolic activity, increased dendritic spine density, and elevated neurotrophin (BDNF) levels in brain regions that are part of cortical-basal ganglia circuitry. These effects were not observed in limbic areas such as the hippocampus. 相似文献
64.
Lawyers are often called upon by their older clients to draft contracts, make up wills or powers of attorney, or provide other forms of legal advice or service. With the increasing numbers of older people in the population, the numbers of older clients for legal practitioners is likely to increase. Older people are also at increased risk for impaired cognitive processes that can affect their ability to make reasoned judgements in civil contracts and other legal arrangements. Here we report on the results of a survey of 302 Australian solicitors as to their experience and practices in determining the capacity of older clients to make legal decisions. The responses, reflecting a 20.7% return rate, showed a wide range of experience in conducting capacity assessments, with a mean of 15.7 years (SD = 10.59). There was a very wide range of practices in determining capacity with no consensus. The most frequent form of questions older clients were asked related to personal and family history. Less than one-quarter asked for the rationale of the decision: the most appropriate form of question in the literature. The results suggest a need for further training of solicitors in the assessment of the capacity of older clients to make legal decisions. 相似文献
65.
Bimanual coordination dynamics in poststroke hemiparetics 总被引:3,自引:0,他引:3
Poststroke hemiparetic individuals (n = 9) and a control group (n = 9) completed a frequency-scaled circle-drawing task in unimanual and bimanual conditions. Measures of intralimb spatial and temporal task accuracy and interlimb coordination parameters were analyzed. Significant reductions in task performance were seen in both limbs of the patients and controls with the introduction of bimanual movement. Spatial performance parameters suggested that the 2 groups focused on different hands during bimanual conditions. In the controls, interlimb coordination variables indicated predictable hand dominance effects, whereas in the patient group, dominance was influenced by the side of impairment and prior handedness of the individual. Therefore, in this particular bimanual task, performance improvements in the hemiplegic side could not be elicited. Intrinsic coupling asymmetries between the hands can be altered by unilateral motor deficits. 相似文献
66.
Heit E Briggs J Bott L 《Journal of experimental psychology. Learning, memory, and cognition》2004,30(5):1065-1081
The authors conducted 3 experiments addressing the issue of how observations and multiple sources of prior knowledge are put together in category learning. In Experiments 1 and 2, learning was faster for critical features, which were predictable on the basis of prior knowledge, than for filler features, and this advantage increased as more observations were made. In addition, learning was fastest for incongruent features that could only be predicted using knowledge from other domains. In Experiment 3, presenting contradictory features that violated prior knowledge led to rote learning rather than use of prior knowledge. The results were simulated with the Baywatch model, which addresses how observations of category members lead to recruitment and selection of sources of prior knowledge. 相似文献
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Schroeder SR Oster-Granite ML Berkson G Bodfish JW Breese GR Cataldo MF Cook EH Crnic LS DeLeon I Fisher W Harris JC Horner RH Iwata B Jinnah HA King BH Lauder JM Lewis MH Newell K Nyhan WL Rojahn J Sackett GP Sandman C Symons F Tessel RE Thompson T Wong DF 《Mental retardation and developmental disabilities research reviews》2001,7(1):3-12
This paper summarizes a conference held at the National Institute of Child Health and Human Development on December 6-7, 1999, on self-injurious behavior [SIB] in developmental disabilities. Twenty-six of the top researchers in the U.S. from this field representing 13 different disciplines discussed environmental mechanisms, epidemiology, behavioral and pharmacological intervention strategies, neurochemical substrates, genetic syndromes in which SIB is a prominent behavioral phenotype, neurobiological and neurodevelopmental factors affecting SIB in humans as well as a variety of animal models of SIB. Findings over the last decade, especially new discoveries since 1995, were emphasized. SIB is a rapidly growing area of scientific interest to both basic and applied researchers. In many respects it is a model for the study of gene-brain-behavior relationships in developmental disabilities. 相似文献
69.
The Kaufman Adolescent and Adult Intelligence Test (KAIT), introduced in 1993, is a relatively new measure for the assessment of intelligence. Because of the test's theoretical foundation, standardization procedure, test items, and score interpretations, it is assumed to be a culturally sensitive measure. However, there is little supporting clinical or empirical evidence. The present case study examined cross-cultural applications of the KAIT using 3 volunteers from diverse cultural backgrounds with differential levels of American acculturation. In addition to test scores, the participants' impressions of the testing process were measured with the Subjective Units of Distress Scale. Preliminary evidence suggests that the KAIT, like its predecessor, the K-ABC, may be useful when working with culturally diverse people. 相似文献
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