Loss of Cells—Loss of Self: Frontotemporal Lobar Degeneration and Human Emotion

ABSTRACT— Frontotemporal lobar degeneration (FTLD) is a devastating disease that profoundly changes emotion, self, and personality while initially sparing many aspects of cognitive functioning. This article reviews research that applies methods from basic affective science to obtain a more precise view of FTLD's impact on emotional functioning. This research indicates that simple forms of emotional reactivity are relatively preserved in the early stages of the disease. In contrast, more complex emotional processes, such as those involved with self-conscious emotions (e.g., embarrassment), emotion regulation, and recognizing emotions in others, are severely impaired. FTLD provides rich opportunities for increasing our understanding of the nature of emotion and of the emotional and social brain.     

Positive Emotions Speed Recovery from the Cardiovascular Sequelae of Negative Emotions

Two studies tested the hypothesis that certain positive emotions speed recovery from the cardiovascular sequelae of negative emotions. In Study 1, 60 subjects (Ss) viewed an initial fear-eliciting film, and were randomly assigned to view a secondary film that elicited: (a) contentment; (b) amusement; (c) neutrality; or (d) sadness. Compared to Ss who viewed the neutral and sad secondary films, those who viewed the positive films exhibited more rapid returns to pre-film levels of cardiovascular activation. In Study 2, 72 Ss viewed a film known to elicit sadness. Fifty Ss spontaneously smiled at least once while viewing this film. Compared to Ss who did not smile, those who smiled exhibited more rapid returns to pre-film levels of cardiovascular activation. We discuss these findings in terms of emotion theory and possible health-promoting functions of positive emotions.     

Empathy: a physiological substrate.

The relation between empathy (defined as the ability to perceive accurately how another person is feeling) and physiology was studied in 31 Ss. Ss viewed 15-min martial interactions and used a rating dial to indicate continuously how they thought a designated spouse was feeling. Rating accuracy was determined by comparing Ss' ratings with identical self-ratings obtained previously from the target spouse. Physiological linkage between S and target was determined using bivariate time-series analyses applied to 5 autonomic and somatic measures obtained from the S during the rating task and from the target spouse during the original conversation. Accuracy of rating negative emotion was greatest when S and target evidenced high levels of physiological linkage across time. Accuracy of detecting positive emotion was related to a state of low cardiovascular around in the S, but not to physiological linkage between S and target.     

Personality research and psychophysiology: General considerations

A general discussion of psychophysiological methods in relationship to personality research is presented for the investigator without an extensive knowledge of psychophysiology. The paper is organized in four sections: (a) advantages inherent in the use of psychophysiological measures (e.g., continuous measurement, sensitivity to sublimal responses); (b) psychophysiological constructs that are particularly well suited to personality research (e.g., different kinds of physiological arousal, normal/pathological distinctions, perceptual states); (c) how to choose a set of psychophysiological measures and special considerations involved with their use (e.g., obstrusiveness, context and timing of measurement, costs, and capabilities); and (d) whether or not to “psychophysiologize” personality research. Within each section, illustrative applications of psychophysiology to personality research are described.     

Role of feedback in voluntary control of heart rate.

The relative effectiveness of biofeedback techniques on the voluntary control of heart rate was examined by randomly assigning 32 Ss to one of four feedback conditions in a bi-directional heart-rate control task: (1) no feedback, (2) binary feedback--S was signaled when an interbeat interval had changed in the correct direction, (3) "real-time," proportional feedback--S was provided information about the relative duration of successive interbeat intervals, and (4) numerical, proportional feedback--each interbeat interval was represented as a numeral indicating its relationship to pre-trial mean by direction and magnitude. Significant over-all heart-rate changes were evidenced for both increase and decrease directions, but no differences were found between the feedback conditions. While these data suggest that feedback may be a relatively insignificant factor in voluntary heart-rate control, it was recommended that further investigation examine the role of feedback within the context of other training, mediating and motivational variables.     

Assessment of cognitive deficiency with the McCarthy Scales and Stanford-Binet: a correlational analysis.

The present study tested matched samples of 15 retarded and 15 normal children on the Stanford-Binet Intelligence Scale and the McCarthy Scales of Children's Abilities. Pearson correlations between Stanford-Binet IQs and the six McCarthy Scale Indexes for retarded subjects were lower than coefficients obtained from the normal subjects and from previous research. While the General Cognitive Index may be interchangeable with IQ in the Normal range of intellectual functioning, this relationship was not found for the retarded subjects in the present study. The "venerable" Stanford-Binet retains its position as the most broadly applicable measure of intellectual functioning. Implications of the study as well as an outline for future research were included.     

Alpha3-integrins are required for hippocampal long-term potentiation and working memory

Integrins comprise a large family of heterodimeric, transmembrane cell adhesion receptors that mediate diverse neuronal functions in the developing and adult CNS. Recent pharmacological and genetic studies have suggested that beta1-integrins are critical in synaptic plasticity and memory formation. To further define the role of integrins in these processes, we generated a postnatal forebrain and excitatory neuron-specific knockout of alpha3-integrin, one of several binding partners for beta1 subunit. At hippocampal Schaffer collateral-CA1 synapses, deletion of alpha3-integrin resulted in impaired long-term potentiation (LTP). Basal synaptic transmission and paired-pulse facilitation were normal in the absence of alpha3-integrin. Behavioral studies demonstrated that the mutant mice were selectively defective in a hippocampus-dependent, nonmatch-to-place working memory task, but were normal in other hippocampus-dependent spatial tasks. The impairment in LTP and working memory is similar to that observed in beta1-integrin conditional knockout mice, suggesting that alpha3-integrin is the functional binding partner for beta1 for these processes in the forebrain.     

Social Neuroscience: Progress and Implications for Mental Health

ABSTRACT— Social neuroscience is a new, interdisciplinary field devoted to understanding how biological systems implement social processes and behavior. Social neuroscience capitalizes on biological concepts and methods to inform and refine theories of social behavior, and it uses social and behavioral constructs and data to inform and refine theories of neural organization and function. We focus here on the progress and potential of social neuroscience in the area of mental health. Research in social neuroscience has grown dramatically in recent years. Among the most active areas of research we found are brain-imaging studies in normal children and adults; animal models of social behavior; studies of stroke patients; imaging studies of psychiatric patients; and research on social determinants of peripheral neural, neuroendocrine, and immunological processes. We also found that these areas of research are proceeding along largely independent trajectories. Our goals in this article are to review the development of this field, examine some currently promising approaches, identify obstacles and opportunities for future advances and integration, and consider how this research can inform work on the diagnosis and treatment of mental disorders.     

Turn down the volume or change the channel? Emotional effects of detached versus positive reappraisal

Cognitive reappraisal, or changing one's interpretation of an event in order to alter the emotional response to it, is thought to be a healthy and an effective emotion regulation strategy. Although researchers recognize several distinct varieties of reappraisal, few studies have explicitly compared the effects of multiple reappraisal strategies on emotional responding. The present study compares the effects of detached and positive reappraisal on thought content, subjective emotional experience, physiological reactivity, and facial expressions of emotion while viewing film clips evoking sadness and disgust. Although both forms of reappraisal reduced overall emotional responding to unpleasant stimuli, the effects of detached reappraisal were stronger in this regard, and positive reappraisal was more likely to maintain subjective experience and facial expression of stimulus-appropriate positive emotions. The two reappraisal strategies also produced somewhat different profiles of physiological responding. Differences between detached and positive reappraisal with respect to subjective experience and facial expression were more pronounced among men than women; the reverse was true for differences with respect to physiological responding. Beyond these effects on individual emotion response systems, detached and positive reappraisal also had somewhat different effects on coherence in change across response systems. Implications for our understanding of emotion regulation processes, and for emotion theory more broadly, are discussed. (PsycINFO Database Record (c) 2012 APA, all rights reserved).