Role of the Disease in the Psychological Impact of Pre-Symptomatic Testing for SCA2 and FAP ATTRV30M: Experience with the Disease, Kinship and Gender of the Transmitting Parent

To identify possible factors affecting the psychological impact of pre-symptomatic testing for spinocerebellar ataxia type 2 (SCA2) and familial amyloid polyneuropathy (FAP ATTRV30M), we studied (1) the effect of previous experience with the disease in the family, (2) kinship with the closest affected relative and (3) gender of affected parent, when adapting to test results; as well as (4) differences in the course of psychological wellbeing in 63 subjects ( 28 at-risk for FAP ATTRV30M, and 35 at risk for SCA2), who pursued predictive testing for these diseases, in Cuba and in Portugal. Our research shows that individuals with little or no experience with the disease in their family exhibited more anxiety; at-risk subjects for SCA2 or FAP ATTRV30M who had a first degree relative with the disease showed lower levels of anxiety and depression during pre-symptomatic testing. Also those with an affected mother had lower levels of depression, either immediately, or one year after receipt of test results. Adaptation to pre-symptomatic testing results differed for subjects at-risk for the two different conditions. Unlike the FAP ATTRV30M families, carriers for SCA2 reported pathological levels of depression immediately after-testing (3 weeks), although those levels had returned to normal levels at 6 months. Subjects at-risk for FAP ATTRV30M tended to have less anxiety than those tested for SCA2, at the one-year follow-up. Overall, depression levels improved over time, while anxiety remained more constant. A longer awareness of the disease in the family, closer kinship, and a transmitting mother all lessened the impact of pre-symptomatic testing, as expressed by the post-test levels of anxiety and depression.     

Bilingualism and brain functional asymmetry

The task of the neural organization of the native language, acquired by a direct method and of another language, studied at school, performed correspondingly by the left and the right hemispheres, was studied in the bilingual patient after unilateral electroconvulsive therapy used in psychiatry. It was established that in such a bilingual type the right hemisphere is concerned with the formation of deep semantic structures of the native language while the left hemisphere is responsible for the formation of second language deep structures and of surface structures of both languages. The effect of language learning method on cerebral organization of bilingualism is postulated.     

New analysis of variance formulas for treating data from mutually paired subjects

The experimental design considered in this paper is one in which each of a group of several subjects is observed in the presence of each of the other subjects of the group, the entire set of possible pairings being repeated or replicated on several occasions. Analysis of variance formulas are described for this somewhat unusual design. Both the model of constants and mixed model are considered. Reliability formulas growing out of the analysis of variance calculations are developed.This work was supported in part by grants M-627; M-627C from the National Institutes of Health, Public Health Service.     

Self-monitoring behavior in a case of severe auditory agnosia with aphasia

This case report describes an unusual combination of speech and language deficits secondary to bilateral infarctions in a 62-year-old woman. The patient was administered an extensive series of speech, language, and audiologic tests and was found to exhibit a fluent aphasia in which reading and writing were extremely well preserved in comparison to auditory comprehension and oral expression, and a severe auditory agnosia. In spite of her auditory processing deficits, the patient exhibited unexpected self-monitoring ability and the capacity to form acoustic images on visual tasks. The manner in which she corrected and attempted to correct her phonemic errors, while ignoring semantic errors, suggests that different mechanisms may underlie the monitoring of these errors.     

An investigation of children's fears and their mothers' fears

Children (75 female, 52 male) in grades 2 through 8 completed the Fear Survey Schedule for Children (FSS-FC). Their mothers completed the same questionnaire twice: once for themselves and a second time to estimate their children's fears. Spearman's rhos indicated that there was a high degree of correspondence between the mothers' rank-ordered estimates of their children's fears and the children's rank-ordered self-reports (=.86 for males, =.96 for females.However, mothers' overall estimates of their children's general fearfulness were significantly correlated only with their daughters' fearfulness, not with their sons'. Further analyses showed that mothers could generally identify their children's highest-rated fears. All test-retest measures were significant. In summary, these results suggest that mothers may provide useful clinical information about their children's specific fears and that the FSS-FC is a reliable instrument with which to assess children's fears.     

Multivariate repeated measures designs

In the social, behavioral, and health researches it is a common strategy to collect data along time on more than one group of participants on multiple dependent variables. To analyse this kind of data is very complicated due to the correlations between the measures taken in different points of the time, and between the answers. Usually to analyse these data the multivariate mixed model, or the doubly multivariate model, are the most frequent approaches. Both of them require combined multivariate normality, equal covariance matrices, independence between the observations of different participants, complete measurements on all subjects, and time-independent covariates. When one ore more of these assumptions are not accomplished these approaches do not control in the correct way the Type I error, and this affects the validity and the accuracy of the inferences. In this paper some solutions that solve the problems with the error Type I will be shown. Several programs for a correct realization of the analyses through the SAS Proc Mixed procedure are presented.     

Decision Making in Social Context in Patients with Suicide Attempt History

Decision making has been found to be altered in suicide attempters, but little is known of their performance in social contexts. Twenty‐seven depressed suicide attempters (DSA), 25 nonsuicidal depressed patients (DP), and 60 healthy participants (HC) were evaluated by a decision‐making task in social context . Results indicated DSA and DP obtained lower gains and invested more money with angry partners. DSA were found to invest less money than DP and HC with happy partners. DSA showed insensitivity toward rewards/punishment contingency, and they did not use the socioemotional stimuli to guide their decisions.