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241.
Mozaz M Garaigordobil M Gonzalez Rothi LJ Anderson J Crucian GP Heilman KM 《Brain and cognition》2006,62(3):241-245
BACKGROUND: Apraxia is neurologically induced deficit in the ability perform purposeful skilled movements. One of the most common forms is ideomotor apraxia (IMA) where spatial and temporal production errors are most prevalent. IMA can be associated Alzheimer's disease (AD), even early in its course, but is often not identified possibly because the evaluation of IMA by inexperienced judges using performance tests is unreliable. The purpose of this study, therefore, is to learn if the Postural Knowledge Test (PKT), a praxis discrimination test that assesses knowledge of transitive (PKT-T subtest) and intransitive (PKT-I subtest) postures and does not require extensive training, is as sensitive and specific as the praxis performance tests. METHODS: We studied 15 subjects with probable AD as well as 18 age-matched controls by having them perform transitive and intransitive gestures to command and imitation, as well as having them discriminate between correct and incorrect transitive and intransitive postures. RESULTS: Overall on all tests, the control subjects performed better than those with AD. In addition all subjects had more trouble with transitive than intransitive gestures. Using a stepwise discriminative analysis, 81.8% of the subjects could be classified according to Group (94.4% of Controls, 66.7% of AD subjects). In this analysis, the PKT-T (transitive posture subtest) was the only measure that contributed to the discrimination of subjects. CONCLUSION: We found that having subjects select the correct transitive hand postures in this "booklet test" was more sensitive than grading their praxis performances even when using judges with extensive training. This suggests that this discrimination test might be an excellent means for diagnosing and screening patients for AD. The reason why recognition of transitive postures is relatively more difficult for our AD subjects is not known. Two possibilities are that the representations for intransitive movements are stronger than those for transitive movements, and hence, more resistant to degradation, or that intransitive acts are stored in parts of the brain not affected by AD. 相似文献
242.
In this study, 361 adult burn survivors completed the Perceived Stigmatization Questionnaire (PSQ), the Social Comfort Questionnaire (SCQ), and other measures. Both the PSQ and SCQ had good internal consistency indices. Factor analysis of the PSQ yielded 3 factors (absence of friendly behavior, confused/staring behavior, and hostile behavior). The SCQ had 1 factor. Conjoint factor analysis with measures of related constructs (body esteem, body-esteem importance, depression, social support) suggested that PSQ and SCQ measure distinct constructs. Correlations with the related psychosocial constructs and burn characteristics suggested the PSQ and SCQ have good convergent and discriminant validity. Limitations of the study are discussed. 相似文献
243.
244.
Meltzer LA 《The American journal of bioethics : AJOB》2006,6(6):28-30; author reply W10-2
245.
Burton LA Rabin L Wyatt G Frohlich J Bernstein Vardy S Dimitri D 《Brain and cognition》2005,59(3):322-329
Affective and Neutral Tasks (faces with negative or neutral content, with different lighting and orientation) requiring reaction time judgments of poser identity were administered to 32 participants. Speed and accuracy were better for the Affective than Neutral Task, consistent with literature suggesting facilitation of performance by affective content. Priming effects were significant for the Affective but not Neutral Task. An Explicit Post-Test indicated no conscious knowledge of the stimulus frequency that was associated with performance facilitation. Faster performance by female vs. male participants, and differential speeds and susceptibility to priming of different emotions were also found. Anger and shock were responded to most rapidly and accurately in several conditions, showed no gender differences, and showed significant priming for both RT and accuracy. Fear and pain were responded to least accurately, were associated with faster female than male reaction time, and the accuracy data showed a kind of reverse priming. 相似文献
246.
A sample of 115 men and women between the ages of 20 and 60 completed the 30-item General Health Questionnaire together with the short-form Revised Eysenck Personality Questionnaire. The data indicate psychological distress so assessed is correlated .43 (p <.001) with Neuroticism and -.26 (p <.01) with Introversion but is unrelated to Psychoticism scores. 相似文献
247.
The demand for genetic counseling services is increasing worldwide. This paper highlights the Australian experience of genetic
counselor education and the history of the profession. The relevance of local factors, including the healthcare system, the
education system and the small population in the evolution of the 1-year training programs are considered as an alternative
model for emerging programs. The development of the education and training processes compared to that of other countries namely
the United States of America (USA), the United Kingdom (UK) and Canada is discussed. The importance of international collaborations
between the programs, to facilitate academic discussion and possible curriculum innovations, and to maintain professional
understanding between genetic counselors is emphasized. Core genetic counseling competencies have been published for the UK
and USA and an Australian set is proposed. In conclusion future directions are considered, including international issues
around genetic counseling certification, reciprocity, and the potential for an Australian role in training genetic counselors
in South East Asia. 相似文献
248.
Mechanisms of belief-desire reasoning. Inhibition and bias 总被引:4,自引:0,他引:4
Biases in reasoning can provide insight into underlying processing mechanisms. We demonstrate a new bias in children's belief-desire reasoning. Children between 4 and 8 years of age were told a story in which a character was mistaken about which of three boxes contained some object. The character wanted to go to one of the boxes, but only if it did not contain the object. In this scenario, the character would be expected to avoid the box where she falsely believed the object to be, but might go to either of the remaining boxes. Though the character was equally likely to go to either box, children were biased to predict that the character would go to the box that contained the object. In a control task, the character had the same desire but did not have a false belief; in this case, children showed no bias, choosing the two correct answers equally often. The observed pattern of bias was predicted by a developmental model of belief-desire reasoning. Competent belief-desire reasoning depends on a process of selection by inhibition in which the best belief content emerges from a set of candidates. 相似文献
249.
Evidence suggests that autism is associated with impaired emotion perception, but it is unknown how early such impairments are evident. Furthermore, most studies that have assessed emotion perception in children with autism have required verbal responses, making results difficult to interpret. This study utilized high-density event-related potentials (ERPs) to investigate whether 3-4-year-old children with autism spectrum disorder (ASD) show differential brain activity to fear versus neutral facial expressions. It has been shown that normal infants as young as 7 months of age show differential brain responses to faces expressing different emotions. ERPs were recorded while children passively viewed photos of an unfamiliar woman posing a neutral and a prototypic fear expression. The sample consisted of 29 3-4-year-old children with ASD and 22 chronological age-matched children with typical development. Typically developing children exhibited a larger early negative component (N300) to the fear than to the neutral face. In contrast, children with ASD did not show the difference in amplitude of this early ERP component to the fear versus neutral face. For a later component, typically developing children exhibited a larger negative slow wave (NSW) to the fear than to the neutral face, whereas children with autism did not show a differential NSW to the two stimuli. In children with ASD, faster speed of early processing (i. e. N300 latency) of the fear face was associated with better performance on tasks assessing social attention (social orienting, joint attention and attention to distress). These data suggest that children with ASD, as young as 3 years of age, show a disordered pattern of neural responses to emotional stimuli. 相似文献
250.
The efficiency of a new strategy to identify back random responding (BRR) on the Personality Assessment Inventory (L. C. Morey, 1991) was studied using random manipulations of item responses from community (904 adult nonpatients) and clinical (1,079 adult patients) respondents. The strategy involved a comparison of short-form and full-instrument T scores on 2 scales found to be particularly sensitive to BRR in a recent study. This strategy was found to be reasonably sensitive and specific to even relatively low levels of BRR. 相似文献