Varying reinforcement magnitude on interval schedules

In Experiment 1, rats were trained on either a random-interval or a variable-interval 60-sec schedule of reinforcement, and reinforcement magnitude was varied across conditions between one and four pellets. Although the two schedules maintained different patterns of behaviour, patterns and rates of responding were not systematically affected by the variation in reinforcement magnitude. In Experiment 2, a regulated probability interval schedule that generated similar rates of reinforcement to those of the schedules of Experiment 1 was used, with the pattern of behaviour generated resembling that typical of a random-interval schedule. Changing reinforcement magnitude again produced few systematic changes in behaviour. In Experiment 3, a variable-ratio schedule was used within a procedure that otherwise resembled that of Experiments 1 and 2. Increasing the reinforcement magnitude now decreased the rates of responding, and examination of the patterns of responding showed that this came about because rates of responding were higher early in the interreinforcer interval in the one-pellet condition. These experiments demonstrate the insensitivity of behaviour under interval schedules to changes in reinforcement magnitude and suggest the operation of mechanisms different from those engaged by ratio schedules and discretetrial learning procedures.     

Cholinergic neurons mediate CaMKII-dependent enhancement of courtship suppression

In Drosophila, calcium/calmodulin-dependent protein kinase II (CaMKII) activity is crucial in associative courtship conditioning for both memory formation and suppression of courtship during training with a mated female. We have previously shown that increasing levels of constitutively active CaMKII, but not calcium-dependent CaMKII, in a subset of neurons can decrease the initial level of courtship and enhance the rate of suppression of courtship in response to a mated female. In this study, we demonstrate that a subpopulation of noncholinergic, nondopaminergic, non-GABAergic neurons can cause CaMKII-dependent reductions in initial courtship, but only cholinergic neurons enhance training-dependent suppression. These data suggest that processing of pheromonal signals in two subpopulations of neurons, likely antennal lobe projection neurons, is critical for behavioral plasticity.     

A new method for calibrating perceptual salience across dimensions in infants: the case of color vs. luminance

We report a new method for calibrating differences in perceptual salience across feature dimensions, in infants. The problem of inter-dimensional salience arises in many areas of infant studies, but a general method for addressing the problem has not previously been described. Our method is based on a preferential looking paradigm, adapted to determine the relative salience of two stimuli. We report here on the case of stimuli differing in color and luminance, though the method has wider potential. We were able to determine on a psychophysical curve the point at which a color contrast was equally salient to infants as a given luminance contrast. We then used these calibrated, 'iso-salient' stimuli in an object memory study. Results showed that 6.5-month-old infants noticed a color, but not a luminance, change while tracking an occluded object. Our method should have numerous applications in the study of bottom-up effects on infant attention and visual working memory.