Formal Methods in the Philosophy of Science

In this article, we reflect on the use of formal methods in the philosophy of science. These are taken to comprise not just methods from logic broadly conceived, but also from other formal disciplines such as probability theory, game theory, and graph theory. We explain how formal modelling in the philosophy of science can shed light on difficult problems in this domain.     

Intergenerational transmission of neuropsychological executive functioning

Relationships between parent and child executive functioning were examined, controlling for the critical potential confound of IQ, in a family study involving 434 children (130 girls and 304 boys) and 376 parents from 204 community recruited families at high risk for the development of substance use disorder. Structural equation modeling found evidence of separate executive functioning and intelligence (IQ) latent variables. Mother’s and father’s executive functioning were associated with child’s executive functioning (beta = 0.34 for father–child and 0.51 for mother–child), independently of parental IQ, which as expected was associated with child’s IQ (beta = 0.52 for father–child and 0.54 for mother–child). Familial correlations also showed a significant relationship of executive functioning between parents and offspring. These findings clarify that key elements of the executive functioning construct are reliably differentiable from IQ, and are transmitted in families. This work supports the utility of the construct of executive function in further study of the mechanisms and etiology of externalizing psychopathologies.     

Temperament Pathways to Childhood Disruptive Behavior and Adolescent Substance Abuse: Testing a Cascade Model

Temperament traits may increase risk for developmental psychopathology like Attention-Deficit/Hyperactivity Disorder (ADHD) and disruptive behaviors during childhood, as well as predisposing to substance abuse during adolescence. In the current study, a cascade model of trait pathways to adolescent substance abuse was examined. Component hypotheses were that (a) maladaptive traits would increase risk for inattention/hyperactivity, (b) inattention/hyperactivity would increase risk for disruptive behaviors, and (c) disruptive behaviors would lead to adolescent substance abuse. Participants were 674 children (486 boys) from 321 families in an ongoing, longitudinal high risk study that began when children were 3 years old. Temperament traits assessed were reactive control, resiliency, and negative emotionality, using examiner ratings on the California Q-Sort. Parent, teacher, and self ratings of inattention/hyperactivity, disruptive behaviors, and substance abuse were also obtained. Low levels of childhood reactive control, but not resiliency or negative emotionality, were associated with adolescent substance abuse, mediated by disruptive behaviors. Using a cascade model, family risk for substance abuse was partially mediated by reactive control, inattention/hyperactivity, and disruptive behavior. Some, but not all, temperament traits in childhood were related to adolescent substance abuse; these effects were mediated via inattentive/hyperactive and disruptive behaviors. This work was supported by NIAAA grant R01-AA12217 to Robert Zucker and Joel Nigg, NIAAA grant R37-AA07065 to Robert Zucker and Hiram Fitzgerald, and NIMH grant R01-MH59105 to Joel Nigg. Martel was supported by 1 F31 MH075533-01A2. The authors thank the participants and Susan Refior, the long term MLS Field Director, whose steadfast commitment and support have made this study possible.     

Advances in functional brain imaging technology and developmental neuro‐psychology: their applications in the Jungian analytic domain

Analytical psychology shares with many other psychotherapies the important task of repairing the consequences of developmental trauma. The majority of analytic patients come from compromised early developmental backgrounds: they may have experienced neglect, abuse, or failures of empathic resonance from their carers. Functional brain imagery techniques including Quantitative Electroencephalogram (QEEG), and functional Magnetic Resonance Imagery (fMRI), allow us to track mental processes in ways beyond verbal reportage and introspection. This independent perspective is useful for developing new psychodynamic hypotheses, testing current ones, providing diagnostic markers, and monitoring treatment progress. Jung, with the Word Association Test, grasped these principles 100 years ago. Brain imaging techniques have contributed to powerful recent advances in our understanding of neurodevelopmental processes in the first three years of life. If adequate nurturance is compromised, a range of difficulties may emerge. This has important implications for how we understand and treat our psychotherapy clients. The paper provides an overview of functional brain imaging and advances in developmental neuropsychology, and looks at applications of some of these findings (including neurofeedback) in the Jungian psychotherapy domain.     

Nazwy cudzysłowowe

Allatum est die 22 Martii 1963     

An overview of the major changes in the 2002 APA Ethics Code

This article summarizes the major changes that were made to the 2002 Ethical Principles and Code of Conduct of the American Psychological Association. The 2002 Ethics Code retains the general format of the 1992 Ethics Code and does not radically alter the obligations of psychologists. One goal of the Ethics Committee Task Force was to reduce the potential of the Ethics Code to be used to unnecessarily punish psychologists. In addition, the revised Ethics Code expresses greater sensitivity to the needs of cultural and linguistic minorities and students. Shortcomings of the 2002 Ethics Code are discussed.     

A poor metabolizer for cytochromes P450 2D6 and 2C19: a case report on antidepressant treatment

Scientific literature has never described a poor metabolizer for both the cytochrome P450 (CYP) 2D6 and the CYP 2C19. They are expected to be rare (<1% in different ethnic groups) and prone to adverse drug reactions with many antidepressants. In an ongoing pharmacogenetic study, after genotyping 1,576 subjects in three Kentucky state hospitals we have found one poor metabolizer for both CYP 2D6 and CYP 2C19, which corresponds to a prevalence of 0.06% (95% CI 0.01 to 0.36). The naturalistic antidepressant treatment of this poor metabolizer for both enzymes is described in this article. As genotyping reaches clinical practice, it will be interesting to prospectively establish whether mirtazapine is a reasonable choice as an antidepressant for these patients, as the data and this case suggest.     

Discursive Construction of Political Categories and Moral Fields: God Versus Rights and Access in a Reproductive Health Legislative Debate

Using a discursive lens, we argue that politicians rhetorically construct categories, storylines, and moral fields. We further claim that such discursive products are action‐oriented toward gaining popular support in a public sphere that is politically fault lined along similar moral orders. As a case in point, we analyze speeches delivered during congressional voting on a Reproductive Health bill (RH bill). Employing a mixed methods strategy, we first implement a quantitative lexical analysis of frequently used words, followed by a qualitative detection of cohering storylines on both sides of the debate. Results show that oppositionists mark their speeches with a deployment of the word God, while bill supporters use the word access conspicuously. One storyline claims that The RH bill stands against God, while the other purports that The RH bill advocates rights and access. Although both storylines assert moral righteousness, they invoke two different moral orders backed by power blocs and the public at large. The God story appeals to a Catholic discourse and the moral order loudly supported by the politically powerful Catholic Bishops Conference of the Philippines. The rights/access narrative references a liberal morality frame maintained by social liberals and Philippine President Aquino. We end our paper by introducing the idea of an intrastate discursive lens to analyze moral fields constructed by politicians, oriented toward winning support from the public at large.