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201.
Deouell LY 《Consciousness and cognition》2002,11(4):546-567
Encoding sensory events entails processing of several physical attributes. Is the processing of any of these attributes a pre-requisite of conscious awareness? This selective review examines a recent set of behavioral and event-related potentials, studies conducted in patients with visual and auditory unilateral neglect or extinction, with the aim of establishing what aspects of initial processing are impaired in these patients. These studies suggest that extinguished visual stimuli excite the sensory cortices, but perhaps to a lesser degree than acknowledged stimuli do. However, encoding spatial attributes of auditory and visual stimuli appear to be preferentially impaired. In light of results from patients with other neuro-behavioral deficits, it is argued that egocentric spatial information is an essential pre-requisite for knowing that an external event occurred. In contrast, information handled by mostly domain-specific circuits, such as in the ventral temporal lobe, supports awareness of the identity of a stimulus, but not of its mere presence. Without spatial information, the stimulus identity will remain implicit. 相似文献
202.
203.
Diphenhydramine is a widely used antihistaminic that is frequently included in over-the-counter medications. Due to its sedating properties, diphenhydramine is used in some hypnotic preparations. Occasionally, patients respond to diphenhydramine with paradoxical excitation. There are no studies on the prevalence of paradoxical excitation in healthy subjects. Diphenhydramine appears to cause mild inhibition of the cytochrome P450 (CYP) 2D6 enzyme. This can be interpreted as competitive inhibition, suggesting that diphenhydramine may be a CYP2D6 substrate. When subjects have at least three active copies of the CYP2D6 gene, they are called ultrarapid metabolizers (UMs) and present high metabolic capacity for CYP2D6 substrates. In the United States, CYP2D6 UMs may account for approximately 1% to 2% of the population. We describe three CYP2D6 UMs who reported paradoxical excitation on diphenhydramine. These cases suggest that in CYP2D6 UMs, diphenhydramine may be converted to a compound that causes excitation due to the abnormally high CYP2D6 activity. Therefore, such individuals may be at higher risk for excitation. Although these are only three anecdotal cases of paradoxical excitation from three CYP2D6 UMs, the reports illustrate the need for larger, more formal studies of diphenhydramine responses in CYP2D6 UMs and of diphenhydramine metabolism. 相似文献
204.
Perceptual Indiscriminability: In Defence of Wright's Proof 总被引:1,自引:0,他引:1
A series of unnoticeably small changes in an observable property may add up to a noticeable change. Crispin Wright has used this fact to prove that perceptual indiscriminability is a non-transitive relation. Delia Graff has recently argued that there is a 'tension' between Wright's assumptions. But Graff has misunderstood one of these, that 'phenomenal continua' are possible; and the other, that our powers of discrimination are finite, is sound. If the first assumption is properly understood, it is not in tension with but is actually implied by the second, given a plausible physical assumption. 相似文献
205.
Leon Culbertson 《Sport, Ethics and Philosophy》2017,11(4):440-452
Stephen Mumford develops his view of sport spectatorship partly through a rejection of an argument he attributes to Best, which distinguishes between two categories of sports, the ‘purposive’ and the ‘aesthetic’, on the basis of the claim that they have different principal aims. This paper considers the principal aim argument and one feature of Mumford’s rejection of that argument, namely, Best’s observation that the distinctions to which he draws attention are based on logical differences. The paper argues that Mumford misconstrues Best’s argument by taking it to be about the intentions of players and athletes, while it is actually about a specific feature of the rules of each sport. 相似文献
206.
207.
Mark Leon 《Philosophia》2011,39(4):733-740
According to Pettit, an account of freedom in terms of rational control fails to suffice, for he argues that such an account
lacks the resources to rule out coerced actions as unfree. The crucial feature of a coerced action is that it leaves the agent
with a choice to make, an apparently rational choice to make. To the extent that it does this, it would seem to leave the
agent as free as he would be in any other case where there is a choice to be made. However, we do not consider actions that
are coerced to be on a par with actions that are not coerced, that are performed freely as we might say. We do not hold agents
similarly responsible in the two sorts of cases. So it would seem that the rational control account fails, for it appears
to fail to vindicate this differential practice. In this paper, I defend the rational control account. I outline two ways
in which proponents of a rational control model, broadly understood, can respond to this criticism. 相似文献
208.
Basic research shows that token‐production and exchange‐production schedules in token economies affect each other as second‐order schedules (i.e., the exchange‐production schedule's requirements affect responding toward the token‐production schedule). This relationship has not been investigated with children in academic settings despite the widespread use of token economies in this context. This study compared the effects of fixed‐ratio (FR) and variable‐ratio (VR) exchange‐production schedules of equal ratios (2, 5, and 10) on responding toward an FR 1 token‐production schedule with a child diagnosed with autism. A concurrent chains assessment was also conducted to assess the participant's relative preference for FR and VR exchange‐production schedule arrangements within her typical discrete trial training. Results showed no difference in response rate between the two schedule types. However, the concurrent chains assessment revealed an exclusive preference for the VR arrangement. 相似文献
209.
BACKGROUND AND OBJECTIVES: Whereas injury to the left hemisphere induces aphasia, injury to the right hemisphere's perisylvian region induces an impairment of emotional speech prosody (affective aprosodia). Left-sided medial frontal lesions are associated with reduced verbal fluency with relatively intact comprehension and repetition (transcortical motor aphasia), but persistent affective prosodic defects associated with right medial frontal lesions have not been described. METHODS: We assessed the prosody of a man who sustained a right medial frontal cerebral infarction seven years prior. RESULTS: While propositional speech expression was normal including syntactic prosody, the patient was impaired at expressing emotions using prosody. His comprehension and repetition of prosody were also impaired but less so than expression. CONCLUSIONS: Right medial frontal lesions can induce an affective aprosodia that primarily impairs expression. 相似文献
210.
Journal of Contemporary Psychotherapy - 相似文献