A poor metabolizer for cytochromes P450 2D6 and 2C19: a case report on antidepressant treatment

Scientific literature has never described a poor metabolizer for both the cytochrome P450 (CYP) 2D6 and the CYP 2C19. They are expected to be rare (<1% in different ethnic groups) and prone to adverse drug reactions with many antidepressants. In an ongoing pharmacogenetic study, after genotyping 1,576 subjects in three Kentucky state hospitals we have found one poor metabolizer for both CYP 2D6 and CYP 2C19, which corresponds to a prevalence of 0.06% (95% CI 0.01 to 0.36). The naturalistic antidepressant treatment of this poor metabolizer for both enzymes is described in this article. As genotyping reaches clinical practice, it will be interesting to prospectively establish whether mirtazapine is a reasonable choice as an antidepressant for these patients, as the data and this case suggest.     

Discursive Construction of Political Categories and Moral Fields: God Versus Rights and Access in a Reproductive Health Legislative Debate

Using a discursive lens, we argue that politicians rhetorically construct categories, storylines, and moral fields. We further claim that such discursive products are action‐oriented toward gaining popular support in a public sphere that is politically fault lined along similar moral orders. As a case in point, we analyze speeches delivered during congressional voting on a Reproductive Health bill (RH bill). Employing a mixed methods strategy, we first implement a quantitative lexical analysis of frequently used words, followed by a qualitative detection of cohering storylines on both sides of the debate. Results show that oppositionists mark their speeches with a deployment of the word God, while bill supporters use the word access conspicuously. One storyline claims that The RH bill stands against God, while the other purports that The RH bill advocates rights and access. Although both storylines assert moral righteousness, they invoke two different moral orders backed by power blocs and the public at large. The God story appeals to a Catholic discourse and the moral order loudly supported by the politically powerful Catholic Bishops Conference of the Philippines. The rights/access narrative references a liberal morality frame maintained by social liberals and Philippine President Aquino. We end our paper by introducing the idea of an intrastate discursive lens to analyze moral fields constructed by politicians, oriented toward winning support from the public at large.     

Examining Identity Styles and Religiosity Among Chilean Undergraduate Students

This study tested Berzsonky’s theory of identity styles and identity commitment in predicting religiosity. Participants were university students (N?=?320) from Chile who were surveyed with the ISI-3 and BRS-6 instruments to measure identity styles and religiosity. Path analysis was used to test the model, which suggested that the three identity styles all had direct effects on commitment. Commitment, in turn, had a direct effect on religiosity. Results revealed that normative, informational, and diffuse-avoidant styles had direct effects on identity commitment, with commitment having a direct effect on religiosity. Also, normative style was shown to have a direct effect on religiosity. Overall, results indicated that commitment is key in explaining religiosity from the perspective of Berzonsky’s theory.     

The mediating effect of leader-member exchange between strengths use and work engagement

This study investigated the mediating effect of leader-member exchange (LMX) (as perceived by subordinates) in the relationship between strengths use and work engagement. Participants numbered 213 employees in a South African financial organisation (females=53.10%, blacks=19.40%). Data on their perceptions of LMX, strengths use and work engagement were collected with the LMX-7, SUDIQ and UWES-17. Structural equation modelling methods with bootstrapping were used to determine the role of LMX in the relationship between strengths use and work engagement. Findings showed that perceived organisational support for strengths use (POSSU) had a positive relationship with both LMX and work engagement, and that LMX had a positive relationship with work engagement. Furthermore, LMX mediated the relationship between POSSU and work engagement, indicating the important role of high quality leader- member exchange in organisations.     

Belonging without commitment: the Christocentric view and the traditionist perspective on modern religion

This essentially theoretical article suggests a novel way to conceptualise the middle spaces of people whose link to religion is perceived as partial and fragmentary – the vast majority of the population in the world of the twenty-first century, who belong to a religious tradition but are quite selective in their observances. We first argue that current conceptualisation of the middle spaces suffers from a predisposition we view as ‘Christocentric’. As the key to an alternative and non-Christocentric approach, we suggest the concept of ‘traditionism’, which permits a new theoretical discussion of the meanings of religion for contemporary individuals who belong to a religious tradition but are not fully committed to its current authorities or affiliated with recognised denominations. As a case study to clarify the new, non-Christocentric conceptualisation, we suggest the religious identity of contemporary ‘Arab Jews’ – Jews whose families originated in the Muslim Middle East – to highlight the potential contribution of a certain Jewish perspective to an understanding of modern religion as tradition and of modern practitioners of religion who belong to no denomination as ‘traditionists’.