Thalamic pathways for active vision

Active vision requires the integration of information coming from the retina with that generated internally within the brain, especially by saccadic eye movements. Just as visual information reaches cortex via the lateral geniculate nucleus of the thalamus, this internal information reaches the cerebral cortex through other higher-order nuclei of the thalamus. This review summarizes recent work on four of these thalamic nuclei. The first two pathways convey internal information about upcoming saccades (a corollary discharge) and probably contribute to the neuronal mechanisms that underlie stable visual perception. The second two pathways might contribute to the neuronal mechanisms underlying visual spatial attention in cortex and in the thalamus itself.     

Marital Breakdown,Shame, and Suicidality in Men: A Direct Link?

The influence of feelings of shame originating from marital breakdown on suicidality is examined. The role of mental health problems as probable mediating factors is also considered. Internalized shame, state (related to separation) shame, and mental health problems were significantly correlated with the score for suicidality during separation in both genders. Tested structural equation model indicated that internalized shame was not directly linked to suicidality, but was mediated either by state shame or mental health problems in males in the context of separation. Our findings seem to indicate that separated males are more vulnerable to the experience of state shame in the context of separation, which might lead to the development of suicidality.     

Conduction aphasia, sensory-motor integration, and phonological short-term memory - an aggregate analysis of lesion and fMRI data

Conduction aphasia is a language disorder characterized by frequent speech errors, impaired verbatim repetition, a deficit in phonological short-term memory, and naming difficulties in the presence of otherwise fluent and grammatical speech output. While traditional models of conduction aphasia have typically implicated white matter pathways, recent advances in lesions reconstruction methodology applied to groups of patients have implicated left temporoparietal zones. Parallel work using functional magnetic resonance imaging (fMRI) has pinpointed a region in the posterior most portion of the left planum temporale, area Spt, which is critical for phonological working memory. Here we show that the region of maximal lesion overlap in a sample of 14 patients with conduction aphasia perfectly circumscribes area Spt, as defined in an aggregate fMRI analysis of 105 subjects performing a phonological working memory task. We provide a review of the evidence supporting the idea that Spt is an interface site for the integration of sensory and vocal tract-related motor representations of complex sound sequences, such as speech and music and show how the symptoms of conduction aphasia can be explained by damage to this system.     

The Unity of Language and Logic in Wittgenstein's Tractatus

The purpose of this paper is to offer an interpretation of the Tractatus’ proof of the unity of logic and language. The kernel of the proof is the thesis that the sole logical constant is the general propositional form. I argue that the Grundgedanke, the existence of the sole fundamental operation N and the analyticity thesis, together with the fact that the operation NN can always be seen as having no specific formal difference between its result and its base, imply that NN is intrinsic to every elementary proposition. I also argue that the picture theory of proposition is an account of the generation of propositions via naming, and that its crucial idea is that naming is the instantiation of the form of a name, which consists in arbitrarily picking out an object as the meaning of the name from those objects sorted out by the form of the name. It follows that the existential quantifier, that is, NN, is intrinsic to naming (and therefore to every elementary proposition). It is then proven that the sole logical constant is the general propositional form. This, together with the truth‐functionality of logical necessity, implies that logic and language are unified via a general rule – logical syntax.     

Catholic Theological Education in a Religiously Pluralistic Age

Abstract. This article describes the transformation of Catholic theological education over the last fifty years from a highly defensive posture vis‐à‐vis other religions toward dialogical engagement with members of other religions and all persons of good will. Until Vatican II, most Catholic theologians and officials distrusted exploration of other religions as leading to a dilution of Catholic identity. Vatican II condemned anti‐Semitism and called for dialogue among religions in pursuit of common values. Since the Council, there have been developments in interfaith education on three levels: religious studies, comparative theology, and inter‐religious practice.     

Unconscious forces: a survey of some concepts in Indian philosophy

In this article, I examine some traditional Indian conceptions of unconscious mental activity. There are concepts in the Indian philosophical tradition, notably saskāras and vāsanās, which can be taken to refer to unconscious mental states and dispositions. My discussion, which is essentially philosophical by nature, is loosely based on the English philosopher C.D. Broad's distinctions concerning the unconscious. Saskāras, which are interpreted realistically in Indian tradition, may manifest themselves as what I (and Broad) call relatively unconscious states. Evidence for this interpretation can be found in discussions concerning the nature of dream state and the supernatural powers of yogis in Indian tradition. It is interesting to try to view the retributive system of karma as an absolutely unconscious system, but this is not a plausible interpretation of the Indian view of karma.     

A general systems approach to suicide prevention: lessons from cardiac prevention and control

The pathology of cardiac disease includes genetic, physical, biochemical, psychological, social, and environmental vectors. Factors contributing to suicide have been identified in these same areas. Survival from an acute cardiac event requires a systematized and multisectoral response. Communities that do not have systematized response capabilities to acute cardiac events have poorer survival outcomes. Suicide prevention and control may also be responsive to an integrated community response system. This paper examines the development of a community cardiac care model, explores potential parallels for a community suicide prevention and control model, and outlines a general systems theory framework for a suicide prevention and control system.     

Conflicting processes in the extinction of conditioned taste aversion: behavioral and molecular aspects of latency,apparent stagnation,and spontaneous recovery

The study of experimental extinction and of the spontaneous recovery of the extinguished memory could cast light on neurobiological mechanisms by which internal representations compete to control behavior. In this work, we use a combination of behavioral and molecular methods to dissect subprocesses of experimental extinction of conditioned taste aversion (CTA). Extinction of CTA becomes apparent only 90 min after the extinction trial. This latency is insensitive to muscarinic and β-adrenergic modulation and to protein synthesis inhibition in the insular cortex (IC). Immediately afterwards, however, the extinguishing trace becomes sensitive to β-adrenergic blockade and protein synthesis inhibition. The subsequent kinetics and magnitude of extinction depend on whether a spaced or massed extinction protocol is used. A massed protocol is highly effective in the short run, but results in apparent stagnation of extinction in the long-run, which conceals fast spontaneous recovery of the preextinguished trace. This recovery can be truncated by a β-adrenergic agonist or a cAMP analog in the insular cortex, suggesting that spontaneous overtaking of the behavioral control by the original association is regulated at least in part by β-adrenergic input, probably operating via the cAMP cascade, long after the offset of the conditioned stimulus. Hence, the performance of the subject in experimental extinction is the sum total of multiple, sometimes conflicting, time-dependent processes.