Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs

Exposure to air pollution is associated with neuroinflammation in healthy children and dogs in Mexico City. Comparative studies were carried out in healthy children and young dogs similarly exposed to ambient pollution in Mexico City. Children from Mexico City (n: 55) and a low polluted city (n:18) underwent psychometric testing and brain magnetic resonance imaging MRI. Seven healthy young dogs with similar exposure to Mexico City air pollution had brain MRI, measurement of mRNA abundance of two inflammatory genes cyclooxygenase-2, and interleukin 1 beta in target brain areas, and histopathological evaluation of brain tissue. Children with no known risk factors for neurological or cognitive disorders residing in a polluted urban environment exhibited significant deficits in a combination of fluid and crystallized cognition tasks. Fifty-six percent of Mexico City children tested showed prefrontal white matter hyperintense lesions and similar lesions were observed in dogs (57%). Exposed dogs had frontal lesions with vascular subcortical pathology associated with neuroinflammation, enlarged Virchow-Robin spaces, gliosis, and ultrafine particulate matter deposition. Based on the MRI findings, the prefrontal cortex was a target anatomical region in Mexico City children and its damage could have contributed to their cognitive dysfunction. The present work presents a groundbreaking, interdisciplinary methodology for addressing relationships between environmental pollution, structural brain alterations by MRI, and cognitive deficits/delays in healthy children.     

Spiritual Exercises in Augustine’s Confessions

Confessions, the narrative of Augustine’s spiritual journey, has been a source of inspiration to readers through many centuries. It addresses the universal striving of the individual towards a ‘way of living’ characterized by internal coherence and an experience of the transcendent. Augustine, using a method of inquiry and engagement, guides the reader through some fundamental exercises: remembering one’s story; facing inner restlessness; entering into dialogue with God; ordering of human love; centering in Christ; participating in a community of faith; living as a pilgrim. Together, they constitute a didactic instrument for the spiritual development of his readers. This paper reconstructs that central purpose in a coherent and practical model.     

Brazilian version of the Protocole Montréal d'Evaluation de la Communication (Protocole MEC): normative and reliability data

The lack of standardized instruments to evaluate communication disorders related to the right hemisphere was verified. A new evaluation tool was developed: Protocole Montréal d'Evaluation de la Communication--Protocole MEC, adapted to Brazilian Portuguese--Bateria Montreal de Avalia??o da Comunica??o--Bateria MAC (Montreal Evaluation of Communication Battery). The purpose was to present stratified normative data by age and educational level, and to verify the reliability parameters of the MEC Battery. 300 individuals, between the ages of 19 and 75 years, and levels of formal education between 2 and 35 years, participated in this study. They were divided equally into six normative groups, according to three age categories (young adults, intermediary age, and seniors) and two educational levels (low and high). Two procedures were used to check reliability: Cronbach alpha and reliability between evaluators, Results were established at the 10th percentile, and an alert point per task for each normative group. Cronbach's alpha was, in general, between .70 and .90 and the average rate of agreement between evaluators varied from .62 to .94. Standards of age and education were established. The reliability of this instrument was verified. The psychometric legitimization of the MEC Battery will contribute to the diagnostic process for communicative disorders.     

Commentary: Are There Good Reasons to Adopt Dynamic Systems Approaches for Explaining Deductive Reasoning?

The focus of this commentary is twofold. First, I examine Faiciuc’s attempts to counter symbolic computationalism as a major theoretical framework for the study of deductive reasoning. Second, I wish to see how far the author goes in her defense of Dynamic Systems Approaches (DSAs) as a more promising framework for explaining logical reasoning. When reading her work, I posed two versions of the same for/against question to myself: How strong is the case against symbolic computationalism? And, on the basis of the author’s argumentation, would one feel justified in adopting DSAs instead? I examine each question in turn, and come to similar conclusions. The article by Faiciuc tackles issues of relevance to any serious effort toward reflecting on the two perspectives being compared. Unfortunately, however, references to studies supporting her claims are rather thin. A better-informed answer to the question raised in the title of the article is still to be given.     

Spatial reconstruction of human motion by means of a single camera and a biomechanical model

The value of the results of the inverse dynamic analysis procedures used in the study of human tasks is dependent on the quality of the kinematic and kinetic data supplied to the biomechanical model that supports it. The kinematic data, containing the position, velocity and acceleration of all anatomical segments of the biomechanical model, result from the reconstruction of human spatial motion by means of the evaluation of the anatomic points positions that enable to uniquely define the position of all anatomical segments. Furthermore, the motion data must be kinematically consistent with the structure of the biomechanical model used in the analysis. The traditional photogrammetric methodologies used for the spatial reconstruction of the human motion require images of two or more calibrated and synchronized cameras. This is due to the fact that the projection of each anatomical point is described by two linear equations relating its three spatial coordinates with the two coordinates of the projected point. The need for the image of another camera arises from the fact that a third equation is necessary to find the original spatial position of the anatomical point. The methodology proposed here substitutes the projection equations of the second camera with the kinematic constraint equations associated with a biomechanical model in the motion reconstruction process. In the formulation the system of equations arising from the point projections and biomechanical model kinematic constraints, representing the constant length of the anatomical segments, are solved simultaneously. Because the system of equations has multiple solutions for each image, a strategy based on the minimization of a cost function associated to the smoothness of the reconstructed motion is devised. It is shown how the process is implemented computationally avoiding any operator intervention during the motion reconstruction for a given time period. This leads to an automated computer procedure that ensures the uniqueness of the reconstructed motion. The result of the reconstruction process is a set of data that is kinematically consistent with the biomechanical model used. Through applications of the proposed methodology to several sports exercises its benefits and shortcomings are discussed.     

Indifference sets of reference points in multi‐objective integer linear programming

Reference point approaches for multi‐objective problems rely on the definition of an achievement scalarizing function that projects reference points onto the non‐dominated solution set. In this paper, we investigate the behaviour of reference points using a Tchebycheff metric‐based scalarizing function in multi‐objective pure integer linear programming (MOILP). Since the non‐dominated solutions are discrete in MOILP, there are multiple reference points that lead to the same solution, i.e. there are indifference sets on the reference point space. We investigate some properties of the reference points in MOILP and also the graphical representation of indifference sets for tri‐objective problems. We further investigate properties of the reference points when additional limitations on the objective function values are introduced. Copyright © 2001 John Wiley & Sons, Ltd.     

Narrative and Clinical Change in Cognitive-Behavior Therapy: A Comparison of Two Recovered Cases

Psychotherapy research suggests that therapeutic change is associated with the emergence and development of innovative moments (IMs)—that is, exceptions to the problematic self-narrative that brought the client to therapy. This study compares two recovered cases of major depression, according to symptom measures, that presented contrasting profiles of evolution of IMs: one typical of successful therapy (Barbara), and another typical of unsuccessful therapy (Claudia). The core conflictual relationship theme (CCRT) was used to study narrative change independently of the innovative moments coding system (IMCS). The results suggest a high congruence between the IMCS and the CCRT profiles. Although Barbara presented changes in the IMCS and the CCRT in a similar way, Claudia's self-narratives (IMs and CCRT), despite symptom change, did not change. The results are discussed, considering the importance of narrative changes in recovery from depression and the maintenance of therapeutic gains.     

Randomized controlled trial of an intervention to change cardiac misconceptions in myocardial infarction patients

There is converging evidence that changing beliefs about an illness leads to positive recovery outcomes. However, cardiac misconceptions interventions have been investigated mainly in Angina or Coronary Heart Disease patients, and less in patients following Myocardial Infarction (MI). In these patients, cardiac misconceptions may play a role in the adjustment or lifestyle changes. This article reports a randomized controlled trial of an intervention designed to reduce the strength of misconceptions in patients after a first MI. The primary outcome was the degree of change in misconceptions and the secondary outcomes were: exercise, smoking status, return to work and mood (anxiety and depression). Patients in the intervention condition (n = 60) were compared with a control group (n = 67) receiving usual care. Both groups were evaluated at baseline and 4, 8 and 12 months after hospital discharge. There was a significant time-by-group interaction for the total score of cardiac misconceptions. Patients in the intervention group significantly decreased their total score of cardiac misconceptions at 4 months compared with the control group and this difference was sustained over time. Patients in the intervention group were also more likely to exercise at the follow-up period after MI than the control group. This intervention was effective in reducing the strength of cardiac misconceptions in MI patients and had a positive impact on health behaviour outcomes. These results support the importance of misconceptions in health behaviours and the utility of belief change interventions in promoting health in patients with Myocardial Infarction.     

How to stay perfect: the role of memory and behavioural traits in an experienced problem and a similar problem

When animals encounter a task they have solved previously, or the same problem appears in a different apparatus, how does memory, alongside behavioural traits such as persistence, selectivity and flexibility, enhance problem-solving efficiency? We examined this question by first presenting grey squirrels with a puzzle 22 months after their last experience of it (the recall task). Squirrels were then given the same problem presented in a physically different apparatus (the generalisation task) to test whether they would apply the previously learnt tactics to solve the same problem but in a different apparatus. The mean latency to success in the first trial of the recall task was significantly different from the first exposure but not different from the last exposure of the original task, showing retention of the task. A neophobia test in the generalisation task suggested squirrels perceived the different apparatus as a different problem, but they quickly came to apply the same effective tactics as before to solve the task. Greater selectivity (the proportion of effective behaviours) and flexibility (the rate of switching between tactics) both enhanced efficiency in the recall task, but only selectivity enhanced efficiency in the generalisation task. These results support the interaction between memory and behavioural traits in problem-solving, in particular memory of task-specific tactics that could enhance efficiency. Squirrels remembered and emitted task-effective tactics more than ineffective tactics. As a result, they consistently changed from ineffective to effective behaviours after failed attempts at problem-solving.     

Unconscious perception and reverie: an intersubjective connection*

This paper discusses an intriguing topic for psychoanalysis: the concept of unconscious communication. Beginning with the concept of unconscious perception, it moves on to figurability and culminates with reverie. Auxiliary concepts, such as receptive unconscious, intersubjectivtiy, countertransferrence and empathy, are discussed in order to articulate the conceptual network on which theoretical arguments are based.